Discover and read the best of Twitter Threads about #renalpath
Most recents (3)
Glomerular crescents 🌙
❓What’s a crescent?
🔬Crescentic GN?
🧩 How are crescents formed?
🔬🗂 Types of crescents? ❗️Pseudo-crescents?
(1/6)
#renalpath #PathResidents #Pathbracket
❓What’s a crescent?
🔬Crescentic GN?
🧩 How are crescents formed?
🔬🗂 Types of crescents? ❗️Pseudo-crescents?
(1/6)
#renalpath #PathResidents #Pathbracket
❓A crescent is defined as two or more layers of cells that are partially or completely filling the Bowman’s space
📥composed of
-Mixture of cells(epithelial cells, monocytes and other leukocytes)
-fibrin
-fibrous matrix. (2/6)
📥composed of
-Mixture of cells(epithelial cells, monocytes and other leukocytes)
-fibrin
-fibrous matrix. (2/6)
🚨Non specific lesion, can be triggered by a variety of glomerular diseases
🔬Crescentic GN(CGN)?
▶️is a PATTERN of injury rather than a specific diagnosis
▶️Integration of clinical data, specific laboratory & immunologic tests can clarify the diagnosis underlying the CGN (3a/6)
🔬Crescentic GN(CGN)?
▶️is a PATTERN of injury rather than a specific diagnosis
▶️Integration of clinical data, specific laboratory & immunologic tests can clarify the diagnosis underlying the CGN (3a/6)
Dear nephrologist:
Not all #renalpath diagnoses are created equal.
Some are much less than others, and acute tubular injury/ ATN is among the least. Here are the reasons:
1. If we look hard enough, tubular injury is almost always present in the kidney bx. 1/
Not all #renalpath diagnoses are created equal.
Some are much less than others, and acute tubular injury/ ATN is among the least. Here are the reasons:
1. If we look hard enough, tubular injury is almost always present in the kidney bx. 1/
Tubular injury can be artificially introduced due to poor preservation (if bx isn't placed in formalin quickly) or during tissue processing. So I only begin to look if the creatinine is elevated and there isn't enough interstitial fibrosis/tubular atrophy to account for this 2/
2. Acute interstitial nephritis can be patchy and may be more prominent in the medulla if a drug reaction. If pt receives any steroids prior to bx, the inflammation dampens quickly. So sampling and timing of bx also matter a lot 3/
