Discover and read the best of Twitter Threads about #redox

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El #envejecimiento es un proceso natural de deterioro del organismo, que afecta múltiples funciones fisiológicas. Estos efectos nocivos están relacionados con una acumulación de mutaciones somáticas, estrés oxidativo, inflamación de bajo grado, daño a las proteínas y...
...disfunción mitocondrial. Se sabe que estos factores son capaces de inducir acortamiento de los telómeros, así como #disbiosis intestinal.
Por otra parte, entre los mecanismos biológicos desencadenados por el ejercicio físico, la atenuación de los mediadores proinflamatorios..
..acompañada de la mejora del estado #redox pueden ser los principales mediadores para la homeostasis de la microbiota y la prevención del desgaste de los telómeros.
 Por lo tanto, esta revisión destaca cómo el estrés oxidativo, la inflamación, el desgaste de los telómeros y la
Read 5 tweets
One of the urban myths of NAD metabolism is the idea that NAD+ is good, while NADH is bad. NAD+:NADH are a redox couple that differ by a hydride group (a proton with 2 electrons) /1
NAD+ picks up the hydride when small molecules are oxidized, forming NADH. NADH donates the electrons to generate ATP and/or heat at the inner mitochondrial membrane. NADH is also the source of electrons in ketone body formation and gluconeogenesis /2
Thus, ketogenesis and gluconeogenesis are run in a reducing environment while fuel oxidation to produce ATP and/or heat requires oxygen as the ultimate electron acceptor to maintain a high NAD+/NADH ratio /3
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The body has a glucose-based economy because that is the main fuel that circulates & what the brain prefers. This is not an argument to eat refined sugar, which is clearly bad, it’s just a fact. DNA & RNA are built from forms of ribose. How do cells convert glucose to ribose? /1
They use NADP+ & the pentose phosphate pathway (PPP). This also produces NADPH and the power to build cellular materials and signaling molecules with the captured electrons #redox #wondersofnature #biochem #NADtwitter /2
No synthetic organic chemist of any skill level can convert glucose to ribose-5-phosphate with the efficiency of the humblest bacterium #enzymes #coenzymes #metabolism #NAD
Read 3 tweets
Redox is a portmanteau term for oxidation-reduction reactions in which one molecule transfers electrons to another one. The mnemonic OIL RIG (oxidation is loss, reduction is gain) reminds us which way the electrons flow /1
NAD+ and NADP+ are awesome electron acceptors. They both accept pairs of electrons associated with a proton (hydride) in protein, fat and carb breakdown /2
This produces reduced coenzymes (NADH and NADPH) that can contribute to production of glucose, ketones, ATP, lipids, steroid hormones, DNA, etc & can detoxify reactive oxygen species /3
Read 4 tweets

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