Discover and read the best of Twitter Threads about #paradoxically
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#NationalSecurity Wrong man was chosen for role of #founder #CDS. Q is whether it was appropriate to raise NSA position to full Cabinet rank & thus reduce NSA's access to contrariarian professional opinion from within/outside Govt. Diverse opinions is only solution to uncertainty
2/ns The qualifications for a founder CDS included, (1) knowledge of all dimensions of war; land, air, sea, (2) Capability in Strategic thinking & methodology, (3) Familiarity with, & ability to understand, frontier technologies(eg hypersonic, lasers), (4) Geopolitical interest
3/ns There is a big diff btwn single-point advice and single-uniform advice. A National security advisor must present alternative views & options, before giving his own advise on which he thinks is best option. If all he receives are views similar to his own, diversity is lost!
a removal of a subset of #Tregs called T follicular regulatory cells (Tfr) from the immune system in #Foxp3-cre Bcl6-fl/fl mice #paradoxically reduces, rather than increases, #peanut-specific #IgE responses.
#immunology
bit.ly/2RAMe8L
#immunology
bit.ly/2RAMe8L
And if you think maybe their knockout mice are some kind of weirdos, not really. Their model also shows that total IgE is increasing as expected. So, the system the authors are using is within acceptable norms.
bit.ly/2RAMe8L
bit.ly/2RAMe8L
The authors then went on to show that IL-10 derived from Tfr cells are important for promoting peanut allergy-producing IgE production. (IL-10 is lesser understood cytokine but it is generally accepted as an immunosuppressant.) #immunology
