Discover and read the best of Twitter Threads about #osteoporosis
Most recents (12)
Calcium supplements increase the risk of dementia inn older people
1. #Calcium tablets are commonly prescribed to older people to lower the risk of #osteoporosis and #fractures. However, calcium tablets may increase the risk of #Dementia.
#neurotwitter #MedTwitter
1. #Calcium tablets are commonly prescribed to older people to lower the risk of #osteoporosis and #fractures. However, calcium tablets may increase the risk of #Dementia.
#neurotwitter #MedTwitter
2. Women (aged 70 or more) taking calcium supplements had a higher risk of all type dementia, vascular and mixed dementia at 5-year follow up.
The risk of dementia was higher in women with previous history of #stroke and those with white matter lesions (WML) on #MRI brain.
The risk of dementia was higher in women with previous history of #stroke and those with white matter lesions (WML) on #MRI brain.
3. In another study, higher serum calcium status (even if not hypercalcemia) was associated with increased risk of #Alzheimers disease in elders. Serum calcium is a useful biomarker in predicting clinical progression in nondemented elders.
1/n A fascinating article came out this summer that argues for a plant-forward omni diet, and it contains a very inflammatory headline:
"Debunking the #vegan myth: The case for a plant-forward omnivorous whole-foods diet"
Note author Loren Cordain, a paleo proponent
"Debunking the #vegan myth: The case for a plant-forward omnivorous whole-foods diet"
Note author Loren Cordain, a paleo proponent
2/n
The abstract:
"Veganism is without evolutionary precedent in Homo sapiens species. Strict adherence to a #vegan diet causes predictable deficiencies in nutrients including vitamins B12, B2, D, niacin, iron, iodine, zinc, high-quality proteins, omega-3, and calcium."
The abstract:
"Veganism is without evolutionary precedent in Homo sapiens species. Strict adherence to a #vegan diet causes predictable deficiencies in nutrients including vitamins B12, B2, D, niacin, iron, iodine, zinc, high-quality proteins, omega-3, and calcium."
3/n
Let's review the images quickly because they show some of these dangers.
Fig. 1. Hazard ratios for all-cause mortality as calculated by Cox proportional hazards multi-variable regression analysis16. P = 0.082.
All cause mortality for #vegans and vegetarians is higher!
Let's review the images quickly because they show some of these dangers.
Fig. 1. Hazard ratios for all-cause mortality as calculated by Cox proportional hazards multi-variable regression analysis16. P = 0.082.
All cause mortality for #vegans and vegetarians is higher!
Medications and Bone Health:
A Thread 🦴🧵
Let’s discuss some medications that can have harmful effects on your bone health
(Not medical advice. Consult first with your physician prior to changing your medications)
Let’s start with the common anti-acids …
#Osteoporosis
A Thread 🦴🧵
Let’s discuss some medications that can have harmful effects on your bone health
(Not medical advice. Consult first with your physician prior to changing your medications)
Let’s start with the common anti-acids …
#Osteoporosis
Proton Pump Inhibitors (PPIs)
These are commonly used in patients with gastroesophageal reflux disease (GERD). Examples include omeprazole, esomeprazole, lansoprazole, pantoprazole, etc.
These are commonly used in patients with gastroesophageal reflux disease (GERD). Examples include omeprazole, esomeprazole, lansoprazole, pantoprazole, etc.
PPIs basically inhibit the formation of acid in the stomach. As such, they can affect nutrient absorption, including calcium.
The body then starts breaking down its own bone in order to obtain calcium for bodily functions
The body then starts breaking down its own bone in order to obtain calcium for bodily functions
Patients with T2DM, CVD, conditions of hyperinsulinaemia, have lower: bone remodelling and osteocalcin levels, and increased rates of fragility fractures.
T2DM “hyperinsulinaemia-osteofragilitas” bone phenotype presents with normal to increased BMD mdpi.com/2227-9059/9/9/…
T2DM “hyperinsulinaemia-osteofragilitas” bone phenotype presents with normal to increased BMD mdpi.com/2227-9059/9/9/…
Hyperinsulinaemia and IR positively associate with increased BMD and fragility fractures
Hyperinsulinaemia enforces glucose fuelling, decreasing NAD+-dependent antioxidant activity:
➡️⬆️ ROS & mt fission,
➡️⬇️ OxPhos ATP production capacity, needed for osteoblasto/cytogenesis.
Hyperinsulinaemia enforces glucose fuelling, decreasing NAD+-dependent antioxidant activity:
➡️⬆️ ROS & mt fission,
➡️⬇️ OxPhos ATP production capacity, needed for osteoblasto/cytogenesis.
Osteocytes directly mineralise and resorb bone, & inhibit mineralisation of their lacunocanalicular space via pyrophosphate.
Hyperinsulinaemia decreases vitamin D availability via adipocyte sequestration, reducing dendrite connectivity, and compromising osteocyte viability.
Hyperinsulinaemia decreases vitamin D availability via adipocyte sequestration, reducing dendrite connectivity, and compromising osteocyte viability.
With 2020 almost over, it's time again to look back at some of the BEST in the #bone field: 🔝20 papers (+extras).
Happy to hear your input! Disclosure: fully subjective ranking!
@ASBMR @AcademyEcts @Osteoporosis_NL @osteoporosisNI @mmse30 @NatalieASims
Happy to hear your input! Disclosure: fully subjective ranking!
@ASBMR @AcademyEcts @Osteoporosis_NL @osteoporosisNI @mmse30 @NatalieASims
#1 Atypical Femoral fractures @NEJM (Black DM et al.)
Risk reduces within months of @Bisphosphonate1 discontinuation. Benefit>risk in any group but less so in Asians and women <65yr
nejm.org/doi/10.1056/NE…
Risk reduces within months of @Bisphosphonate1 discontinuation. Benefit>risk in any group but less so in Asians and women <65yr
nejm.org/doi/10.1056/NE…
-side note- @ECTS_science very useful systematic review and recommendations for managing osteoporosis following AFFs.
ncbi.nlm.nih.gov/pmc/articles/P…
And oral BPs may not only reduce fractures but also cardiovascular events
pubmed.ncbi.nlm.nih.gov/32717068/
@Dr_BoAbrahamsen @prieto_alhambra
ncbi.nlm.nih.gov/pmc/articles/P…
And oral BPs may not only reduce fractures but also cardiovascular events
pubmed.ncbi.nlm.nih.gov/32717068/
@Dr_BoAbrahamsen @prieto_alhambra
اليوم موضوعنا من اشهر واهم مواضيع العظام 😍اللي هو
#Osteoporosis
#هشاشةالعظام
تعالوا نشوف تفاصيل المرض في هذا الثريد 👇🏼
#Osteoporosis
#هشاشةالعظام
تعالوا نشوف تفاصيل المرض في هذا الثريد 👇🏼
ايش يعني هشاشة عظام ؟ Osteoporosis
is a bone disorder characterized by low bone density, impaired bone
architecture, and compromised bone strength predisposing to fracture.
is a bone disorder characterized by low bone density, impaired bone
architecture, and compromised bone strength predisposing to fracture.
Pathophysiology
Two cells are responsible for promoting bones health:
⭕️osteoblast (promotes the
formation of bone tissues) خلايا بناءة
⭕️osteoclast (promotes bone breakdown) خلايا هادمة
Osteoporosis occurs when the resorption (bone breakdown) exceeds the formation.
Two cells are responsible for promoting bones health:
⭕️osteoblast (promotes the
formation of bone tissues) خلايا بناءة
⭕️osteoclast (promotes bone breakdown) خلايا هادمة
Osteoporosis occurs when the resorption (bone breakdown) exceeds the formation.
Please #SaveTheDate #KarensHalfMarathon 6th September 2020 #BedfordHalfMarathon2020 I am doing it to help some of the little #rescues that desperately need our #help please #donate if you can and your #virtual support on the day would be amazing gofundme.com/f/karens-half-… #RT
Facebook group here for the links contained in the screenshot, that was the only way I could do this on twitter to tell the story of why I’m doing the #BedfordHalfMarathon2020
facebook.com/groups/2353595… gf.me/u/ypy3iq
facebook.com/groups/2353595… gf.me/u/ypy3iq
@RadioForBedford @bedfordindy @BedfordLabour @BedfordTown @BedfordBluesRFC @BBC3CR @IN2BEATS @paulross @bedfordrunfest hello all could you please give my #fundraiser a #RT please #KarensHalfMarathon I’m trying not to let #AnkylosingSpondylitis and #Osteoporosis hold me back
#COVIDー19
#Osteoporosis
Está bien claro que nuestros mayores no solo son más vulnerables frente al #Covid_19 sino que además lo son frente a la osteoporosis que se agravó con el #confinamiento
#hilo Revisión
⬇️⬇️ sci-hub.im/downloads-ii/2…
#Osteoporosis
Está bien claro que nuestros mayores no solo son más vulnerables frente al #Covid_19 sino que además lo son frente a la osteoporosis que se agravó con el #confinamiento
#hilo Revisión
⬇️⬇️ sci-hub.im/downloads-ii/2…
1️⃣Asesoramiento del riesgo de #fracturas
Va a salir a la calle y su movilidad se ha visto reducida
2️⃣ Los pacientes que reciben
bisfosfonatos intravenosos pueden tener reacciones flu-like. Toca hacer diagnóstico diferencial
3️⃣Evitar la interrupción de #denosumab
Va a salir a la calle y su movilidad se ha visto reducida
2️⃣ Los pacientes que reciben
bisfosfonatos intravenosos pueden tener reacciones flu-like. Toca hacer diagnóstico diferencial
3️⃣Evitar la interrupción de #denosumab
4️⃣¿Cambios en el tratamiento?
El cambio de un antirresortivo a un agente osteoanabolizante puede ser complicado ahora
5️⃣ Y POR SUPUESTO, hacer hincapié en el entrenamiento SOBRE TODO DE FUERZA domiciliario
El cambio de un antirresortivo a un agente osteoanabolizante puede ser complicado ahora
5️⃣ Y POR SUPUESTO, hacer hincapié en el entrenamiento SOBRE TODO DE FUERZA domiciliario
1/x I’ll be teaching on #osteoporosis diagnosis and management tomorrow to future physicians @MUCOM_Indy. A few thoughts... #WorldOsteoporosisDay
2/x For most people #osteoporosis is a silent disease until a fracture disrupts and potentially changes their life. Many never regain full mobility or independence. Just 1 fragility fracture raises risk of a second fracture and increases risk of mortality. #WorldOsteoporosisDay
3/x For other #osteoporosis patients, fear of fracture causes elevated anxiety and decreases their well-being. The anxiety may cause patients to self-limit their physical activity and actually increase fall risk and fracture risk. #WorldOsteoporosisDay
Incredibly refreshing to read this review that details how 👉components of the intestinal #microbiome (+ the metabolites they express) can regulate bone metabolism (#osteoporosis)☝️by influencing host metabolism, immunity + the endocrine environment: onlinelibrary.wiley.com/doi/full/10.10…
For example LCA, a ligand synthecized by intestinal #bacteria 👉 can bind into the vitamin D receptor (#VDR) where it reduces the ability of vitamin D to activate osteocalcin and RANKL (two human genes associated w/ bone formation): onlinelibrary.wiley.com/doi/full/10.10…
The level of complexity + nuance in the review (in which many pathways, #microbes + metabolites can influence osteoporosis progression) 👉 helps explain why recent RCTs that relied on #vitamin D supplemetation alone to treat bone health have failed: thelancet.com/journals/landi…
5 Life-Enhancing Benefits of Strength Training for Adults Over 55 🏋🏽♀️
Strength training and regular aerobic activity help prevent many chronic and degenerative diseases related to #aging.
Here are 5 #health benefits that strength training can provide to older adults...
1/7
Strength training and regular aerobic activity help prevent many chronic and degenerative diseases related to #aging.
Here are 5 #health benefits that strength training can provide to older adults...
1/7
1. Stronger Muscles
Stronger muscles protect the joints of the body. Muscle weakness can cause the hips, spine, and shoulder to be less stable and more prone to injury.
A stronger body can withstand the #stress of daily activities.
#strengthtraining
Stronger muscles protect the joints of the body. Muscle weakness can cause the hips, spine, and shoulder to be less stable and more prone to injury.
A stronger body can withstand the #stress of daily activities.
#strengthtraining
2. Chronic Pain Relief
Many #chronicpain issues are a result of muscle weakness and muscle imbalances.
Strength exercises can correct these imbalances to restore the function and integrity of the joints.
Many #chronicpain issues are a result of muscle weakness and muscle imbalances.
Strength exercises can correct these imbalances to restore the function and integrity of the joints.
Thread: Decreasing muscle mass in aging: The harmful effects and how to counteract ––
Tags: #sarcopenia #aging #ageing #HealthyAging #MSKover50 #resistance training, #weights #physicalmobility #muscle, #protein
#osteoporosis #bone #fracture #falls
Image: iofbonehealth.org/what-sarcopenia
Tags: #sarcopenia #aging #ageing #HealthyAging #MSKover50 #resistance training, #weights #physicalmobility #muscle, #protein
#osteoporosis #bone #fracture #falls
Image: iofbonehealth.org/what-sarcopenia
Thread: 🔽muscle in #aging ––#Sarcopenia RX, prevention –––
#MSKover50 #resistance #physicalmobility #osteoporosis #bone #fracture #falls
Lifespan vs. Healthspan: Why We Need Muscle for #HealthyAging.
runnersworld.com/health-injurie…
+
Live Strong and Prosper...
link.springer.com/article/10.100…
#MSKover50 #resistance #physicalmobility #osteoporosis #bone #fracture #falls
Lifespan vs. Healthspan: Why We Need Muscle for #HealthyAging.
runnersworld.com/health-injurie…
+
Live Strong and Prosper...
link.springer.com/article/10.100…
Thread: Sarcopenia in #Aging: RX, prevention –––
🔽
Biochemical Pathways of #Sarcopenia &Their Modulation by Physical #Exercise: A Narrative Review
frontiersin.org/articles/10.33… …
H/T @MathewPiasecki Tags: #MSKover50
LT: Key RE: onset & progress
RT: Rec. of @ACSMNews & @American_Heart
🔽
Biochemical Pathways of #Sarcopenia &Their Modulation by Physical #Exercise: A Narrative Review
frontiersin.org/articles/10.33… …
H/T @MathewPiasecki Tags: #MSKover50
LT: Key RE: onset & progress
RT: Rec. of @ACSMNews & @American_Heart
