Discover and read the best of Twitter Threads about #VDR
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This general mechanism is also key to human chronic #disease development👇A persistent pathogen evolves to create a protein similar in shape to that of its host..and now this #pathogen protein docks into host receptors to control immune/metabolic signaling to its own advantage
2/2 To better understand what I’m talking about please watch this video I recorded on the topic (I try to explain it in simple terms): 
3/3 Here’s an example of the phenomenon from our own papers 👉 The Vitamin D Nuclear Receptor (VDR) plays a central role in controlling the innate #immune response (it expresses TLR2, cathelicidin antimicrobial peptides etc)...
Incredibly refreshing to read this review that details how 👉components of the intestinal #microbiome (+ the metabolites they express) can regulate bone metabolism (#osteoporosis)☝️by influencing host metabolism, immunity + the endocrine environment: onlinelibrary.wiley.com/doi/full/10.10…
For example LCA, a ligand synthecized by intestinal #bacteria 👉 can bind into the vitamin D receptor (#VDR) where it reduces the ability of vitamin D to activate osteocalcin and RANKL (two human genes associated w/ bone formation): onlinelibrary.wiley.com/doi/full/10.10…
The level of complexity + nuance in the review (in which many pathways, #microbes + metabolites can influence osteoporosis progression) 👉 helps explain why recent RCTs that relied on #vitamin D supplemetation alone to treat bone health have failed: thelancet.com/journals/landi…
