Discover and read the best of Twitter Threads about #mitochondrial
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So excited to finally share our paper, now available as a #bioRxiv preprint!
We found that enhancing #mtDNA replication can be highly deleterious, causing #Ferroptosis and neonatal 🫀#HeartDisease. 🧵thread coming soon..
biorxiv.org/content/10.110…
#newpublication #mitochondria
We found that enhancing #mtDNA replication can be highly deleterious, causing #Ferroptosis and neonatal 🫀#HeartDisease. 🧵thread coming soon..
biorxiv.org/content/10.110…
#newpublication #mitochondria
This project would not have been possible without the fantastic work from many people, so thank you all! @ASW_lab, @Kivela_lab, @WickstromLab, @JMitophile, @AWartiovaara et twitterless al.
@HelsinkiUniMed @helsinkiuni @HelsinkiUniMed @MitoResearch @uniofjyvaskyla @UniEastFinland
@HelsinkiUniMed @helsinkiuni @HelsinkiUniMed @MitoResearch @uniofjyvaskyla @UniEastFinland
Recent years have brought several promising approaches to treat different kinds of #mitochondrial dysfunction, and increasing #mtDNA amount has been proposed to be beneficial for certain defects.
The Aus Senate this Weds will vote on so-called 'three-parent #babies'. These would be #donorconceived babies, genetically the child of 3 people not 2, made by an unregulated, for-profit industry, where there are serious questions about the future for the resulting child. A 🧵
Three-parent babies are made from #mitochondrialDNA donation. For eg: you fertilise a would-be mother's egg, and a donor egg. You suck the middle (the pronucleus) out of both. You put the would-be mother's pronucleus in the 'shell' of the donor egg. You gestate the embryo.
This is to avoid a child inheriting mitochondrial disease from the mother. What it means is: the child inherits DNA from 3 people - bio father, the would-be mother, and the donor. This *is inheritable*. If it's a girl baby, DNA from THREE people will be passed on to her children.
1/12 Check our latest work led by our Postdoc @fbonnay_vienna where we describe a fundamental role of mitochondrial fusion and oxidative metabolism for tumor cell immortalization, in the larval brain of #Drosophila melanogaster. sciencedirect.com/science/articl… 
2/12 Our tumor model of choice is derived from asymmetrically dividing neural stem cells (NSCs) called type II Neuroblasts, deficient for the tumor suppressor gene brain tumor or brat. brat-deficient type II Neuroblasts give rise to big and lethal brain tumors.
3/12 We first observed that brat tumors have increased oxidative metabolism compared to normal brains, with increased oxygen consumption and TriCarboxylic Acid (TCA) cycle metabolites.
I'd like to point out that while the resolution of a #chronicillness was striking, what is more striking is the rapid descent into Wernicke's in a hospitalized 90 yo woman - a descent so striking that she went into respiratory distress necessitating a #ventilator. 1/
Upon giving #IVthiamine per a #wernickesprotocol at 200mg 3X p/d she woke up, after just 2 days of thiamine treatment, and the ventilator was removed. What could this tell us about the use of thiamine in #COVID19? Perhaps the cluster symptoms we see are really just a variation 2/
thiamine deficiency - one that is being missed by practitioners everywhere because we're not looking at the #mitochondria for answers. 3/
I want to talk about 2 papers that highlight the role of mitochondria in what are likely the progression of symptoms assoc with #COVID19. Note these papers are not about #covid but highlight important pathways. 1/
1st paper - Intracellular ATP is req. 4 #mitochondrial #apoptotic pathways rat #cardiac #myocytes ncbi.nlm.nih.gov/pubmed/12909326 2/
Key findings: apoptosis and necrosis are part of the same pathway, initiated by same mito sequences but are distinguished by time and severity, where the delimiting factor is available intracellular #ATP. 3/
Excellent example of how a #microbe (p. gingivalis acting as a persistent #pathogen and not a “trigger”) 👉 can modulate a “cell danger-type response” by dysregulating #mitochondrial metabolism (ATP signaling impacting ROS generation etc): ncbi.nlm.nih.gov/m/pubmed/28725…
In fact I’m keeping a very peeled eye on p. gingivalis these days 👉 B/c it’s also very interesting that p.gingivalis + the toxic proteases it creates (called gingipains) were recently identified in the #brains of #Alzheimer's patients: ncbi.nlm.nih.gov/m/pubmed/30746…
Aaand this team just found that 👉 when p. gingivalis was fed to mice, it modulated gut #microbiome composition + the gut immune response in a manner that aggravated arthritis symptoms: ncbi.nlm.nih.gov/m/pubmed/28761…
