Discover and read the best of Twitter Threads about #inhibitor
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#immunosuppression
IMMUNE CONTROL POINTS AND COVID-19
✅IMMUNOLOGIC CONTROL POINT MOLECULES ARE #INHIBITOR RECEPTORS EXPRESSED IN IMMUNE CELLS THAT TRIGGER IMMUNOSUPPRESSOR SIGNALING PATHWAYS.
IMMUNE CONTROL POINTS AND COVID-19
✅IMMUNOLOGIC CONTROL POINT MOLECULES ARE #INHIBITOR RECEPTORS EXPRESSED IN IMMUNE CELLS THAT TRIGGER IMMUNOSUPPRESSOR SIGNALING PATHWAYS.
These molecules are crucial to maintaining self-tolerance. 👉SIGNALING THROUGH THESE MOLECULES MAY TAKE IMMUNE EFFECT CELLS (ESPECIALLY T CELLS) TO A STATE KNOWN AS "DEPLETION". T cell depletion is defined by reduced effector function, poor memory responses
👉 due to sustained expression of immune checkpoint molecules (such as PD1, # CTLA4, # LAG3 ...). There are numerous types of activating and inhibitory interactions that occur between antigen presenting cells (APC) and T cells and thus regulate the nature of immunity.
SC2 MPro inhibitors alternatives, plant flavonoids.
1/n
#MPro #SARSCoV2 #inhibitor
Kaempferol, Quercetin, and Rutin
were able to bind at the substrate binding pocket of 3CLpro with high affinity and interact with the active site residues ..
chemrxiv.org/engage/chemrxi…
1/n
#MPro #SARSCoV2 #inhibitor
Kaempferol, Quercetin, and Rutin
were able to bind at the substrate binding pocket of 3CLpro with high affinity and interact with the active site residues ..
chemrxiv.org/engage/chemrxi…
such as His41 and Cys145 through hydrogen bonding and hydrophobic interactions. In fact, the binding affinity of Rutin was much higher than Chloroquine (1000 times) and Hydroxychloroquine (100 times) and was comparable to that of the reference drug Remdesivir. 2/n
The results suggest that natural compounds such as flavonoids have the potential to be developed as novel inhibitors of SARS-CoV-2. 3/n
Whys #NavPancham considered generally good?#NavPancham is #Genesis, #Progression, #CauseEffect relations. In #KaalPurush #Kundali, if #Jaatak is denoted by #Lagan, his/her progeny is denoted by the #PanchamBhaav while the father of this #Jaatak is the #NavamBhaav of the #Chart...
Many ancient #Astrologers have expressed that a #Bhaav can find #Catalyst 5 houses behind itself or 9 houses away from itself (same thing).
So in effect if there is any good connection of the #Navam #Bhaav with the #Lagan (or #Navam #Bhaav from any other #Bhaav) ...
So in effect if there is any good connection of the #Navam #Bhaav with the #Lagan (or #Navam #Bhaav from any other #Bhaav) ...
the particular #Bhaav in question can get #SuPrabhaav. The #Lagan or any other #Bhaav is always the #PanchamBhaav from the #Navam.Hence the theory- #NavPancham, is generally considered #YogKaarak.
Basic theories apply as always...
Explaining #Shadow #Grah #Rahu...
Basic theories apply as always...
Explaining #Shadow #Grah #Rahu...
