Discover and read the best of Twitter Threads about #MPro
Most recents (2)
SARSCoV2 BA.2 #subvaraints carrying #MainProtease (#MPro) mutations associated with reduced #nirmatrelvir (#Paxlovid) activity
Top #NSP5 (MPro) mutations: H164N, G15S, T135I
Should investigate if these NSP5 mutations are also associated with Paxlovid rebound.
1/n
Top #NSP5 (MPro) mutations: H164N, G15S, T135I
Should investigate if these NSP5 mutations are also associated with Paxlovid rebound.
1/n
Mpro mutations associated with reduced nirmatrelvir activity (≥3-fold higher Ki values): G15S (4.4-fold), T135I (3.5-fold), S144A (91.9-fold), H164N (6.4-fold),
H172Y (233-fold), Q189K (65.4-fold), and D248E (3.7-fold).
fda.gov/media/155050/d…
2/n
H172Y (233-fold), Q189K (65.4-fold), and D248E (3.7-fold).
fda.gov/media/155050/d…
2/n
Omicron-MPro-Pax-Tracker: (by sublineage, by state/division, by county/location):
3/n
public.tableau.com/app/profile/ra…
3/n
public.tableau.com/app/profile/ra…
SC2 MPro inhibitors alternatives, plant flavonoids.
1/n
#MPro #SARSCoV2 #inhibitor
Kaempferol, Quercetin, and Rutin
were able to bind at the substrate binding pocket of 3CLpro with high affinity and interact with the active site residues ..
chemrxiv.org/engage/chemrxi…
1/n
#MPro #SARSCoV2 #inhibitor
Kaempferol, Quercetin, and Rutin
were able to bind at the substrate binding pocket of 3CLpro with high affinity and interact with the active site residues ..
chemrxiv.org/engage/chemrxi…
such as His41 and Cys145 through hydrogen bonding and hydrophobic interactions. In fact, the binding affinity of Rutin was much higher than Chloroquine (1000 times) and Hydroxychloroquine (100 times) and was comparable to that of the reference drug Remdesivir. 2/n
The results suggest that natural compounds such as flavonoids have the potential to be developed as novel inhibitors of SARS-CoV-2. 3/n
