Discover and read the best of Twitter Threads about #herpesvirus
Most recents (7)
Se sugiere que el enigma de la #hepatitis aguda grave de etiología desconocida en #niños lo explica la coinfección con #adenovirus y virus adenoasociado de tipo 2 (AAV2), y con menos frecuencia el virus del herpes 6 (HHV6)
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espanol.medscape.com/verarticulo/59…
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espanol.medscape.com/verarticulo/59…
Dos estudios independientes: Un estudio fue dirigido por la University of Glasgow, en Glasgow, y el otro por el Great Ormond Street Hospital de Londres, ambos en Reino Unido.
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Los investigadores del estudio de Glasgow usando secuenciación y PCR, confirmaron la presencia de virus adenoasociado de tipo 2 en el plasma de los 9 casos de hepatitis de inicio agudo y en el hígado de los 4 pacientes analizados.
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Ein eher verbreitetes Missverständnis: #Bakterien und #Viren sind nicht per se Krankheitserreger! Und selbst potentielle Krankheitserreger führen nicht unbedingt zwangsläufig zu Krankheit.
Crazy aber wahr!
Ein Thread über unser hochkomplexes Zusammenleben mit #Mikroben!
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Crazy aber wahr!
Ein Thread über unser hochkomplexes Zusammenleben mit #Mikroben!
🧵1/19
Unser Körper besteht aus ungefähr 10 Billionen Zellen– das ist eine 1 mit 13 Nullen😳! Das Verrückte ist: in uns und auf uns leben mind. nochmal genauso viele Bakterien! Vor allem im Darm, aber auch auf der Haut, den Schleimhäuten, und manche wohl sogar im Gewebe!
2/19
2/19
Aber damit nicht genug– auch Viren leben in und auf uns, und zwar grob nochmal 10 Billionen! Die meisten davon sind #Bakteriophagen, befallen also die Bakterien; aber zunehmend wird klar, dass viele darunter sind, die menschliche Zellen infizieren.
nature.com/articles/s4157…
3/19
nature.com/articles/s4157…
3/19
¿Que sabemos de los resultados publicados en 𝑺𝒄𝒊𝒆𝒏𝒄𝒆 que asocian al Virus Epstein-Barr como factor de riesgo para el desarrollo de Esclerosis Múltiple? Resumo algunos datos en un #hilo
scientificamerican.com/article/epstei…
scientificamerican.com/article/epstei…
El Virus Epstein-Barr (VEB, o EBV de las siglas en inglés) es de la familia de los virus del herpes #herpesvirus y puede causar mononucleosis infecciosa. Tras la infección permanece latente en los linfocitos B el resto de la vida. Es muy común y el 95% de los adultos lo tienen.
La Esclerosis Múltiple (EM, o SM de sus siglás en inglés) es una enfermedad inflamatoria desmielinizante crónica del sistema nervioso central de etiología desconocida.
For everybody looking for a break from #coronaviruses check out our @virusfusion007 recent results on a #herpesvirus known as #HHV8 or #KSHV.
The preprint is available at @biorxivpreprint bit.ly/39mvx9I.
The main findings are discussed in the 🧵 that follows (1/n)
The preprint is available at @biorxivpreprint bit.ly/39mvx9I.
The main findings are discussed in the 🧵 that follows (1/n)
KSHV and its cousin EBV use an envelope glycoprotein complex called gH/gL to bind to #EphA2 receptor tyrosine kinase to gain access to host cells. We set to determine the structure of the KSHV gH/gL-EphA2 complex and perform functional studies to understand the mechanism (2/n)
While we were gathering the functional data Su et al. published the 3.2 A structure and provided some interesting insights few months ago.
But under our 'no scoop good enough' mantra we kept working and obtained some cool data that we can now share (3/n)
go.nature.com/3sIbQRL
But under our 'no scoop good enough' mantra we kept working and obtained some cool data that we can now share (3/n)
go.nature.com/3sIbQRL
Happy 2021! @MBVanElzakker and I are excited to share our new article published in #Immunometabolism: “Pathogens Hijack Host Cell Metabolism: Intracellular Infection as a Driver of the Warburg Effect in Cancer and Other Chronic Inflammatory Conditions”: ij.hapres.com/htmls/IJ_1341_…
2/ In the paper, we detail molecular mechanisms by which #viral, #bacterial, and #parasite intracellular pathogens can induce, or contribute to, a Warburg-like #metabolism in infected host cells in order to meet their own replication and nutritional needs.
3/ We also discuss how host defense towards #infection may impact cellular metabolic changes (including how #mitochondria can participate in the innate immune response towards infection)
@sickanddamned @__ice9 @GemzME @Cov19longtail @VirusesImmunity @MBVanElzakker Walker hi - I very much disagree that #Borrelia or #EBV are typically ” long gone” in infected patients who develop chronic symptoms.
@sickanddamned @__ice9 @GemzME @Cov19longtail @VirusesImmunity @MBVanElzakker 2/ There is a large body of literature showing that even if such #organisms cannot be found in blood, they can persist in certain tissues or the central #nervous system where they are very hard to identify clinically
@sickanddamned @__ice9 @GemzME @Cov19longtail @VirusesImmunity @MBVanElzakker 3/ This is particularly obvious w/ EBV which is a #herpesvirus. Herpesviruses almost never “clear” after #infection, and symptom resolution is due to the immune system’s ability to contain the #virus in a non-replicating state
So I’ve decided to #interview many of the researchers/MDs I collaborate with or know as friends. That’s b/c most have an incredible base of knowledge and unique skillsets that need to be shared with a wider audience!
2/ I started w/ Dharam Ablashi, who co-discovered the #virus human #herpesvirus 6 (HHV6) along w/ Robert Gallo in the 1980s. Here is the #interview, which ended up documenting one of the most fascinating + informative conversations I’ve ever had: microbeminded.com/2020/06/28/int…
3/ Overall, Dharam and I talked abt his own extensive research on #HHV6, challenges he faced in moving the work forward, plus his opinion on key studies that clarify the pathogenic role of HHV6-A + HHV6-B in neurological disorders such as #MS, #epilepsy, #ME/CFS and #Alzheimer’s
