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For everybody looking for a break from #coronaviruses check out our @virusfusion007 recent results on a #herpesvirus known as #HHV8 or #KSHV.
The preprint is available at @biorxivpreprint bit.ly/39mvx9I.
The main findings are discussed in the 🧵 that follows (1/n)
The preprint is available at @biorxivpreprint bit.ly/39mvx9I.
The main findings are discussed in the 🧵 that follows (1/n)
KSHV and its cousin EBV use an envelope glycoprotein complex called gH/gL to bind to #EphA2 receptor tyrosine kinase to gain access to host cells. We set to determine the structure of the KSHV gH/gL-EphA2 complex and perform functional studies to understand the mechanism (2/n)
While we were gathering the functional data Su et al. published the 3.2 A structure and provided some interesting insights few months ago.
But under our 'no scoop good enough' mantra we kept working and obtained some cool data that we can now share (3/n)
go.nature.com/3sIbQRL
But under our 'no scoop good enough' mantra we kept working and obtained some cool data that we can now share (3/n)
go.nature.com/3sIbQRL
