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2dary analysis of @PlaNeT2_trial out now. @KDraat @ESteyerberg @Willem_Pieter @BloodJournal #ebneo #FOAMneo #neohematol . A thread. Primary result of trial: more bleeding/death in neonates treated acc to prophylactic platelet tx threshold of 50 comp to 25. 1/3
We reanalyzed the data to look for subgroups of neonates that might benefit from the 50 threshold after all. Instead of using conventional subgroup analyses we used a more robust predicted baseline risk approach. More info? Start reading here: doi.org/10.1136/bmj.k4… 2/3
We did not identify subgroups that benefit from the 50 threshold, though model needs further improvement. Suggests prophylactic platelet tx threshold of 25 appropriate for all preterm neonates, incl those at high risk of bleed/mortality. 3/3 @sanquin @LUMC_Leiden @amsterdamumc
