Discover and read the best of Twitter Threads about #brainstem

Most recents (6)

Amy Proal, PhD

@microbeminded2

People are asking me: what if we did a similar autopsy study to look for #viruses in ME/CFS? Well, several teams that performed single autopsy studies on #ME/CFS patients found evidence of persistent enterovirus infection in subject brain/body tissue

https://twitter.com/microbeminded2/status/1473721448342687754

2/ Enteroviruses are (like SARS-CoV-2) single-stranded RNA viruses. They include the coxsackieviruses, poliovirus, echoviruses + rhinoviruses. These viruses cause about 10–15 million #infections each year in the USA alone

3/ This 1994 ME/CFS autopsy study identified positive PCR sequences with similarity to coxsackievirus B3 in samples from the #brainstem and hypothalamus (and also in muscle and heart tissue): acpjournals.org/doi/10.7326/00…

Read 7 tweets

Amy Proal, PhD

@microbeminded2

@MBVanElzakker and I are excited that our new paper on biological factors that may contribute to the development of LongCovid/PASC was published today: frontiersin.org/articles/10.33…

2/ The paper details mechanisms by which RNA #viruses beyond just #SARS-CoV-2 have be connected to long-term health consequences.

3/ It also reviews literature on acute #COVID-19 and other virus-initiated chronic syndromes such as post-#Ebola syndrome or #ME/CFS to discuss different scenarios for #LongCovid/#PASC symptom development.

Read 10 tweets

Ricardo López, MD

@PearlsNeurology

A brief refresher about #Antibiotic-associated #Encephalopathy #Twittorial #Tweetorial #AMS
Inspired from today's #NoonConference topic
#MedTwitter #MedStudentTwitter #NeuroTwitter #NeurotwitterNetwork #MedEd @MedTweetorials #NeurologyResident #Neurology #RITEReview

1/

Antibiotics are commonly prescribed medications in the inpatient and outpatient setting and it's important to recognize #AdverseEvents, including idiosyncratic reactions, such as #encephalopathy.

2/

Antibitiotics associated with #Encephalopathy:
- Beta lactams
- #Cephalosporins (#Cefepime is the most common,
Ceftazidime)
- Imipenem
- #Penicillin procaine
- Fluoroquinolones
- Macrolides (clarithromycin)
- TMP-SMX
- #Metronidazole
- Isoniazid

3/

Read 14 tweets

Amy Proal

@microbeminded2

I study the illness #ME/CFS - a neuroinflammatory condition that usually begins w/ a #viral infection (sometimes a #respiratory infection!). I have argued for years that infecting #pathogens tied to the illness might persist in the central nervous system (CNS) of such patients

2/ While I realize this article is talking about acute #infection and #COVID19 - it explains that #SARS-CoV-2 “might infect neurons, raising questions about whether there could be effects on the brain that play a role in patients’ deaths:”
the-scientist.com/news-opinion/l…

3/ Matt Anderson, (one of my favorite Beth Israel pathologists!) states, “Some of the purely respiratory symptoms that you might attribute to the #disease, the inability to get air into the #lungs, might actually be defects in #respiration controlled by the #nervous system.”

Read 8 tweets

Amy Proal, PhD

@microbeminded2

Interesting! 👉 This study in mice found that persistent herpes #virus (HSV) activity detected in the brainstem...may primarily result from the transport of reactivated HSV from the trigeminal nerve into the brainstem: jvi.asm.org/content/jvi/ea…

Context on the study 👉”Investigating HSV reactivation in the #brainstem is a reasonable first step to understanding #HSV pathology in the CNS, since...lesions in the front of the brain, characteristic of Alzheimer’s, may originate from #neurons located in the brainstem.”

But as the team explains, the study of HSV’s activity + reactivation in the central nervous system can inform the study of many #neuroinflammatory conditions (in addition to Alzheimer’s)

Read 3 tweets