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Recently, we published the concluding part III of the #SPIRAL model, which we were working on since 2016.
Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells
I'm going to explain the significance of this model.
preprints.org/manuscript/202…
Pathological T Helper Polarization Requires Pre-existing Cross-Reactive Memory T Cells
I'm going to explain the significance of this model.
preprints.org/manuscript/202…
In part I published in 2018, we introduced the SPIRAL model. It proposes that cross-reactivity is the basic unit that drives the evolution of adaptive immune system and it is thymus-derived regulatory T cells, Tregs, that rely on cross-reactive epitopes to control other T cells
We also proposed that thymus-derived #Foxp3 Tregs rely on #CrossReactive epitope derived from the friendly gut microbiota to survive and function in the periphery. So one of the main roles of gut microflora is to supply #Tregs with epitopes.
onlinelibrary.wiley.com/doi/10.1111/sj…
onlinelibrary.wiley.com/doi/10.1111/sj…
