Most recents (8)

@TaNaishaJ

1/5 "#SARSCoV2 #infection is associated with a #surprising number of #morbidities."

#amyloidogenesis #aβ #fibrils #COVID19 #SARSCoV2
#spike
#protein

pubs.acs.org/doi/10.1021/ja…

2/5 "#Uncanny #similarities with #amyloid-#disease associated #blood #coagulation and #fibrinolytic #disturbances together with #neurologic and #cardiac problems led us to investigate the #amyloidogenicity of the #SARSCoV2 #spike #protein (#S-protein)."

3/5 "#Amyloid #fibril #assays of peptide library mixtures and theoretical predictions identified seven #amyloidogenic #sequences within the S-protein."

Read 5 tweets

TaNaisha NOT MILD Lee

@TaNaishaJ

1/4 "Using #PEPMatch, a newly developed #bioinformatics package which predicts #peptide similarity within specific #amino #acid mismatching parameters consistent with published #MHC binding capacity,..."

nature.com/articles/s4159…

2/4 "... we discovered that #nucleocapsid #protein shares significant overlap with 22 #multiple #sclerosis (#MS)-associated proteins, including #myelin #proteolipid #protein (#PLP).

#MultipleSclerosis

3/4 "Further computational evaluation demonstrated that this #overlap may have #critical #implications for #Tcell responses in #multiple #sclerosis (#MS) patients and is likely unique to #SARSCoV2 among the major #human #coronaviruses."

Read 4 tweets

Laurent ARNAUD

@Lupusreference

Did you miss the talk "Panorama of #lupus in 2020?" I did yesterday for @LupusEurope?

No worries, I'm starting a #tweeter #SLE #thread so that you can pick up the slides you're interested in 👍

Check below for the SLIDES ⬇️

Slide #1
Current classification of #Lupus

Slide #2
What is #lupus #SLE
#Lupusawareness

Read 18 tweets

Dr Eliza Wolfson

@eliza_coli

8 years since the first manuscript draft but it's finally here!

The interaction of #Ecoli O157 :H7 and #Salmonella Typhimurium #flagella with host cell #membranes and cytoskeletal components | #Microbiology #Pathogenesis #Thread

microbiologyresearch.org/content/journa…

@strain9000 @ArielBlocker @MicrobioSoc This all started many 🌑🌒🌓🌔🌕🌖🌗🌘🌑 ago...

Jo Elvidge and I were looking at the role of #flagella in early infection of #Salmonella and #Ecoli in relevant animal tissue models (🐖🐄)

We spotted what looked like very intimate adherence...

It was a toughie to quantify back then with the tools we had, but every time we looked, we saw it 🤓

Read 9 tweets

Prof. Akiko Iwasaki

@VirusesImmunity

Very excited to share this work by the heroic team - @carolilucas Pat Wong @sneakyvirus @tiago21bio et al on “Longitudinal analyses reveal immunological misfiring in severe COVID-19”. A thread on our findings. #COVID19 #Pathogenesis (1/n)

nature.com/articles/s4158…

In this study, we enrolled COVID+ patients and analyzed their immune responses and viral load over the course of their hospital stay. We also compared samples from COVID- healthy health care workers (HCWs) as comparison. (2/n)

As reported by others, we found that COVID patients with severe disease have low T cell numbers and increased monocytes and neutrophils. We also found eosinophils come up in patients. This is bizarre 🧐 (3/n)

Read 16 tweets

MrKunJenna

@KunJenna

"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..."

Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964

In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily.

Read 68 tweets

UF One Health Center

@OneHealthUF

With the #COVID19 outbreak, it is important to use language responsibly. Here is the first entry of our new #ContagiousWords series, defining the buzzwords and terminology dominating today's conversation. #Pandemic #PandemicsCost

@ilariacapua Language is powerful, so we must be sure and accurate in the ways we communicate science. #Epidemic #ContagiousWords #COVID19

@ilariacapua Today's #ContagiousWords entry: #Contagion
#COVID19

Read 64 tweets