Discover and read the best of Twitter Threads about #OrganOnChip
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Proud moment! My First, First Author paper is finally published! Happy Monday News! 🥳
An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis ➡️nature.com/articles/s4200… @CommsBio #PAH #PhD #PhDChat
Here's the Tweetorial👇
An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis ➡️nature.com/articles/s4200… @CommsBio #PAH #PhD #PhDChat
Here's the Tweetorial👇
Inspired by #OrganOnChip technology, we sought to create a model of the pulmonary vascular wall in order to investigate the underlying mechanisms of vascular remodelling in Pulmonary Arterial Hypertension (#PAH). 
All of our chips were produced in-house from raw materials.
We created an endothelial-smooth muscle cell interface on our chips and applied laminar fluid shear stress (6 dynes/cm^2) over the endothelial monolayer which enhanced barrier function when compared to static controls.
We created an endothelial-smooth muscle cell interface on our chips and applied laminar fluid shear stress (6 dynes/cm^2) over the endothelial monolayer which enhanced barrier function when compared to static controls.
