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A few words about #Niagen--the journey from yeast to ppl. Pellagra was cured with foods 100 yrs ago. Elvehjem showed NA & NAM are pellagra-preventive 80 yrs ago. Extensive data show beneficial effects of high dose NA in ppl, though uses are limited by flushing. /1
RDA guidelines indicate that ~15 mg/day prevents pellagra but no research has established amounts of a "niacin equivalent" to optimize health. Our 15 yrs work on #nicotinamideriboside establish that it is a uniquely powerful NAD precursor in animal models of metabolic stress. /2
Clearly, at high doses, the 3 forms of B3 are not equivalent. Value of NR derives from wide expression of NRK1 gene & induced expression of NRK1,NRK2 when NAD is under attack (best examples: fatty liver, neurodegeneration, heart failure). /3
