Discover and read the best of Twitter Threads about #Neuroimaging
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Dear #hr in #niin #ksom #usc, I know you are busy,but could you spend 8 mins on my emails pls? I sent 6 emails from April to June, and called you every day this week, but I didn’t get any reply. #neuroscience EAD will be expired at 07/10😩@USC @KeckMedUSC @KECKSchool_USC @USCNIIN 
Thanks,friends in #twitter in #niin,#ksom, #usc, in #neuroscience, #neuroimaging, #neuroradiology. I really appreciate your support. I got the email this afternoon. It’s my fault. Even leave, leave with pride, grace, and gratitude, no regret. The 4 yrs will be the best memory in
my life, although it is also the hardest 4 yrs. Hope other colleagues could take my lessons, and prepare everything earlier in the future.
1) As an intern, GP or a gen med resident, you are constantly exposed to MR imaging of the brain. This is a complicated imaging modality that requires a radiologist for optimum analysis and reporting. But you must know the basic sequences and how to identify them.
2) The five most common sequence that we use in internal medicine are the T1 (with or without contrast), T2, FLAIR, DWI and ADC sequences. SWI/GRE sequences are also used in certain cases.
3) First check whether the soft tissue of the scalp and the skull (black) are visible or not --> if yes, you are dealing with T1,T2 or FLAIR.
#WeekendLecture
#Tenecteplase #TNK
Part 1
✅3rd generation rtPA
🧬Targeted genetic upgrade
3 specific alterations to #alteplase molecule:
👉⬆️Half life
👉⬆️Binding affinity for #fibrin
👉⬆️Resistance to inactivation by #PAI-1
bit.ly/3pqbEb1
#Tenecteplase #TNK
Part 1
✅3rd generation rtPA
🧬Targeted genetic upgrade
3 specific alterations to #alteplase molecule:
👉⬆️Half life
👉⬆️Binding affinity for #fibrin
👉⬆️Resistance to inactivation by #PAI-1
bit.ly/3pqbEb1
#WeekendLecture
#TNK
👉⬆️T1/2 allows single bolus dosing and⬆️clot exposure to TNK
👉Higher affinity to fibrin-rich clots & + potent/faster clot #lysis vs alteplase
👉 < consumption of fibrinogen/plasminogen/ a2- antiplasmin👉⬇️systemic fibrinolytic effect👉⏬risk for bleeding
#TNK
👉⬆️T1/2 allows single bolus dosing and⬆️clot exposure to TNK
👉Higher affinity to fibrin-rich clots & + potent/faster clot #lysis vs alteplase
👉 < consumption of fibrinogen/plasminogen/ a2- antiplasmin👉⬇️systemic fibrinolytic effect👉⏬risk for bleeding
#WeekendLecture
#TNK
First analysis in stroke patients was a #dose-scalation safety study
There was no #symptomatic ICHs in dosis of 0.1-0.2-0.4mg/kg, and 15% (2 of 13) in 0.5mg/kg
No differences in clinical outcomes
bit.ly/3DNHamV
#TNK
First analysis in stroke patients was a #dose-scalation safety study
There was no #symptomatic ICHs in dosis of 0.1-0.2-0.4mg/kg, and 15% (2 of 13) in 0.5mg/kg
No differences in clinical outcomes
bit.ly/3DNHamV
Interested in doing/analyzing #neuroimaging studies in #infants or young #children? New pre-print by @GaabLab led by the wonderful @TedTuresky:
#Neuroimaging the rapidly developing #brain: Current challenges for #MRI studies in the first five years of life
osf.io/7q4cm/
#Neuroimaging the rapidly developing #brain: Current challenges for #MRI studies in the first five years of life
osf.io/7q4cm/
Rapid and widespread changes in #brain anatomy and physiology in the first five years of life present substantial challenges for developmental #MRI studies. One persistent challenge is that methods best suited to earlier developmental stages are suboptimal for later stages
This new review describes the data acquisition, processing, & analysis challenges that introduce these potential biases when conducting & analyzing data from infants and young children & attempts to elucidate decisions & recommendations that can optimize developmental comparisons
Let’s do a quick one on #clinicaldecisionmaking and #neuroimaging. See bright spot on MRI T2 Brain just means increased water -could be any insult to the brain - #infection #inflammation #ischemia #neoplasm are the top 4 you gotta have in your brain. Pun intended. #MedTwitter
Then you think - active or inactive process? If it’s actively destroying the BBB, it’ll enhance on contrast enhancement. So get MRI with and without contrast. Why without? T2 shine-through - but that’s for another time. #MedStudentTwitter #neurology #neurologyresident
Now the important question here is what you do - remember that nice poem on #theroadnottaken by #robertfrost? 2 widely diverging choices - to immunosuppress or not to immunosuppress. #tobeornottobe #hamlet #MedTwitter #AcademicTwitter #MedStudentChat
New preprint from the @GaabLab with first author @JenniferMZuk : "White matter in #infancy is prospectively associated with language outcome in kindergarten" biorxiv.org/content/10.110…
We would love to hear your feedback! Please find a summary below #infant #mri #brain #language 1/9
We would love to hear your feedback! Please find a summary below #infant #mri #brain #language 1/9
We think that our paper is the first #longitudinal #neuroimaging study to document white matter organization in #infancy & follow-up w these infants 5 years later to characterize their #language outcomes. Recent work in the field of #developmental cognitive #neuroscience...2/9
...proposes that the first 2 years of life signify the most rapid period of #brain development & sets a foundation for long-term development, but there has yet to be direct evidence with respect to brain structure due to a lack of longitudinal designs with #neuroimaging. ...3/9
#neuroimaging folks, we really need a high-quality #python package or Class to read and work with volumetric and surface atlases. Atlases are central to our work and are still not first class objects!!
I proposed aspects of this few years ago for nilearn: github.com/nilearn/nilear…
I proposed aspects of this few years ago for nilearn: github.com/nilearn/nilear…
I’m trying to deal with different atlases for #graynet : github.com/raamana
And it’s not as clean and beautiful as I’d like it to be so far.
Happy to collaborate and work with others to achieve niatlas package.
And it’s not as clean and beautiful as I’d like it to be so far.
Happy to collaborate and work with others to achieve niatlas package.
Atlases shouldn’t be handled on a per-tool or per-ecosystem basis, and we really need a nibabel-like tool dedicated to atlases, with high interoperability across various popular tools.
Late in the game, but finally... our 1st @GaabLab preprint
Multifactorial pathways facilitate #resilience among kindergarteners at risk for #dyslexia: A longitudinal behavioral and #neuroimaging study biorxiv.org/content/10.110…
J. Zuk, J. Gabrieli @tiffanyphogan 1/2
Multifactorial pathways facilitate #resilience among kindergarteners at risk for #dyslexia: A longitudinal behavioral and #neuroimaging study biorxiv.org/content/10.110…
J. Zuk, J. Gabrieli @tiffanyphogan 1/2
co-authors @elizsn @olaozpa @_yingyingwang @yu_sea0052 and Jade Dunstan #reading #literacy #DTI #MBE #edchat Feedback highly appreciated!
First author has a twitter handle now @JenniferMZuk !
Submitted #neuroimaging paper using #DTI to a highly regarded Educational journal, an attempt to bridge the 2 fields I am very passionate about. Sadly, the reviews just illustrate how far apart these fields are...in this thread I want to highlight three major challenges we face
1) Methodology: You would hope that the paper would be reviewed by a reviewer with neuroimaging background or at least some basic knowledge. However, reviewer asked us why fMRI was not included, which in his/her view could give us some insights into gray matter differences.
S/he further asked why there was no functional task during DTI & why we looked at predefined tracts & not more globally in whole brain. These questions show that there's no basic understanding of functional vs structural imaging methods & experimental design of imaging studies
