Discover and read the best of Twitter Threads about #F486P
Most recents (5)
BREAKING🔔 The 19th paper from G2P-Japan🇯🇵 is out at Lancet Infectious Diseases @TheLancetInfDis . We elucidated the virological characteristics of new SARS-CoV-2 variant of interest, XBB.1.16 (aka #Arcturus) Please RT🔥 1/
thelancet.com/journals/lanin…
thelancet.com/journals/lanin…
XBB.1.16 = XBB.1 + #F486P, #E180V, and #T478K in spike.
cf. XBB.1.5 = XBB.1 + #F486P in spike (i.e., XBB.1.16 = XBB.1.5 + #E180V and #T478K in spike). 2/
cf. XBB.1.5 = XBB.1 + #F486P in spike (i.e., XBB.1.16 = XBB.1.5 + #E180V and #T478K in spike). 2/
A phylogenetic tree shows that XBB.1.16 is a descendant of XBB.1, not of XBB.1.5. 3/
#拡散希望 速報🔔 G2P-Japan🇯🇵の論文第19弾「オミクロン亜株XBB.1.16の特性解析」を、Lancet Infectious Diseases @TheLancetInfDis に発表しました。本研究では、世界で流行拡大中の #オミクロン XBB.1.16株（俗称 #アークトゥルス）の特性を解明しました。1/
thelancet.com/journals/lanin…
thelancet.com/journals/lanin…
2022年末にアメリカ🇺🇸で突如感染爆発を始めたのがXBB.1.5です。この株は、XBB.1のスパイクに #F486P という変異を獲得したものです。それに対し、XBB.1.16のスパイクは、この #F486P に加えて、#E180V と #T478R というふたつの変異を持っています。2/
XBB.1.5とXBB.1.16は共通する変異もありますが、分子系統学的にはそれぞれ独立に誕生したものです。つまり、XBB.1.5とXBB.1.16は、「XBB.1の子供たち（＝XBB.1.5とXBB.1.16は兄妹）」であって、XBB.1.16は「XBB.1.5の子供」ではありません。3/
NEW: @UKHSA Variant Technical Briefing 49
🔘 XBB.1.5 and CH.1.1 designated variants
🔘 BQ.1 severity and VE estimates
assets.publishing.service.gov.uk/government/upl…
🔘 XBB.1.5 and CH.1.1 designated variants
🔘 BQ.1 severity and VE estimates
assets.publishing.service.gov.uk/government/upl…
Start with overall variant picture for England to 1 Jan:
This is Omicron soup. 🍜 Each colour a different Omicron lineage.
BQ.1.1 in light purple 🟣 is the most common at 51% of cases
CH.1.1 in yellow 🟡 is 20% and growing
XBB.1.5 in dark red 🔴 is 4.5% and growing
This is Omicron soup. 🍜 Each colour a different Omicron lineage.
BQ.1.1 in light purple 🟣 is the most common at 51% of cases
CH.1.1 in yellow 🟡 is 20% and growing
XBB.1.5 in dark red 🔴 is 4.5% and growing
🛑 sampling bias warning❗️
English sequenced cases are *highly* skewed to older ages, due to prioritising samples for sequencing from hospital patients and care homes.
The median age of English 🏴 sequenced COVID-19 cases is
76 years old 👴🏻 👵🏻
English sequenced cases are *highly* skewed to older ages, due to prioritising samples for sequencing from hospital patients and care homes.
The median age of English 🏴 sequenced COVID-19 cases is
76 years old 👴🏻 👵🏻
BREAKING🔔 We introduce the latest work from G2P-Japan🇯🇵 focusing on the virological characteristics of new SARS-CoV-2 lineage of concern, XBB.1.5 (aka #Kraken), which is rapidly spreading in the US🇺🇸 Please RT! Preprint/peer-review paper will come soon🔥 1/
XBB.1.5 = XBB.1 + #F486P in spike. We also found that a part of XBB.1.5 has reversion mutation in Y144del (=XBB.1.5 + #ins144Y) in spike. Because #Y144del evades antiviral immunity and decreases pseudovirus infectivity, its reversion might be also critical. 2/
First, a brilliant young talent, @jampei2, showed that the relative basic reproduction number (Re) of XBB.1.5 is >1.2-fold greater than the parental XBB.1 (❗️). Importantly the "1.2-fold difference" is similar to the differences between BA.1 versus BA.2 and BA.2 versus BA.5. 3/
#拡散希望 速報🔔 G2P-Japan🇯🇵の最新作「オミクロン亜株XBB.1.5の性状解析」を、論文/プレプリント公開前に速報します（図はメイキング）。本研究では、流行拡大中の#オミクロン XBB.1.5株（通称 #クラーケン）の性質を解明しました🔥 1/
2022年末にアメリカ🇺🇸で突如感染爆発を始めたのがXBB.1.5株です。この株は、↓で我々が報告しているXBB.1株（G2P-Japan🇯🇵プレプリント第15弾）が、スパイクに #F486P という変異を獲得したものです。2/
それに加え、XBB系統が持っていた #Y144del という欠損が復帰したXBB.1.5株（XBB.1.5+ins144Y）も確認されています。Y144del という変異は、ブレイクスルー血清への抵抗性の上昇と、ウイルスの感染力の減少に作用する変異です（G2P-Japan🇯🇵プレプリント第15弾より）。3/
