Discover and read the best of Twitter Threads about #Evusheld
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#covid19 : après l'#Evusheld (anticorps monoclonaux) c'est donc le #Paxlovid (antiviral) qui perd en efficacité à mesure que le #SARSCoV2 mute, ce que la quasi disparition des mesures de #prévention favorise. ⤵️
science.org/doi/10.1126/sc…
1/
science.org/doi/10.1126/sc…
1/
Le contraste avec les prises de position des sociétés savantes en mars @SFAR_ORG @SPILF_ @LaSF2H @agenceANRS @SFMU_MS @HAS_sante m'est émétique.
Que dire du ministère de la @Sante_Gouv qui se précipite dès la publication de l'avis HAS sur l'obligation vaccinale des #soignants
2/
Que dire du ministère de la @Sante_Gouv qui se précipite dès la publication de l'avis HAS sur l'obligation vaccinale des #soignants
2/
pour lever celle concernant le #SARSCoV2 ? Déclenchant ainsi la joie des anti-sciences et ouvrant la #BoîteDePandorre des demandes des #suspendus. #quipouvaitprévoir ? 🤔
L'avis HAS recommande fortement les vaccins #covid19, #diphtérie, #tétanos et #poliomyélite (qui restent
3/
L'avis HAS recommande fortement les vaccins #covid19, #diphtérie, #tétanos et #poliomyélite (qui restent
3/
#TranchesDeCovid
Relire aujourd'hui ce message d'il y a 3 ans.
Me rendre compte que je relayais @linhlandao qui citait @FLAHAULT sans alors suivre leurs publications ni interagir avec eux.
Mesurer combien j'ai développé mon expertise.
1/
Relire aujourd'hui ce message d'il y a 3 ans.
Me rendre compte que je relayais @linhlandao qui citait @FLAHAULT sans alors suivre leurs publications ni interagir avec eux.
Mesurer combien j'ai développé mon expertise.
1/
En profiter pour partager de nouveau le fondamental schéma en emmental d'@MackayIM pour les moyens coordonnés à engager pour se protéger des virus aéroportés (en commentaire).
🎶 #LesGestesProtecteursSontNosAmisPourLaVie 🎶 #Adoptonsles 🎶
2/
🎶 #LesGestesProtecteursSontNosAmisPourLaVie 🎶 #Adoptonsles 🎶
2/
💉 #vaccination anti #sarscov2
Le vaccin diminue les risques de formes graves en phase aiguë (immédiat post infectieux) et donc la pression hospitalière.
Il ne protège pas des risques de #séquelles du #covidlong pour lesquelles, malgré les progrès de la recherche (au moins
3/
Le vaccin diminue les risques de formes graves en phase aiguë (immédiat post infectieux) et donc la pression hospitalière.
Il ne protège pas des risques de #séquelles du #covidlong pour lesquelles, malgré les progrès de la recherche (au moins
3/
So, exasperated with the total lack of mitigations against a pandemic, I settled in to write one of my verbose threads...then realised I'd done it already and the situation hasn't really changed much...aside from getting worse!
We STILL have next to no
We STILL have next to no
investment into the future of clean air, no public awareness of viral prevalence (SARS-CoV2, and its' mates), little ability to act altruistically because testing has evaporated and supported isolation remains a figment of most people's imagination...there's nothing safeguarding
our workplaces, schools, universities, public transport, shops or other public spaces, no masks, mis/dis-information is rife and anti-vax narratives now echo round the house of commons thanks to certain feckless mockeries of public representatives...
Most people think the COVID
Most people think the COVID
#covidlong : le sénateur d'Oklahoma assume que sa mise en retrait de la vie politique est liée aux #séquelles de son infection #sarscov2. D'autres sont concernés mais préfèrent garder le silence.
Assumer sa #vulnérabilité n'a rien de honteux et il serait temps aussi que plus
1/
Assumer sa #vulnérabilité n'a rien de honteux et il serait temps aussi que plus
1/
que temps que les personnes 'en vue' concernées osent aussi le dire pour commencer à lever le voile.
Cela contribue du travail de #prévention car
🔹 être vacciné
🔹et/ou avoir déjà été contaminé mais sans symptôme ou avec des symptômes modérés et sans séquemld
ne garantissent
2/
Cela contribue du travail de #prévention car
🔹 être vacciné
🔹et/ou avoir déjà été contaminé mais sans symptôme ou avec des symptômes modérés et sans séquemld
ne garantissent
2/
absolument qu'il en sera de même lors des infections suivantes.
1️⃣ La vaccination ↘️ de 15 % le risque de covidlong ( et tw. suivants).
2️⃣ Le risque de séquelles ↗️ à chaque réinfection
(theconversation.com/reinfection-wi…)
Par conséquent et en l'absence de mise
3/
1️⃣ La vaccination ↘️ de 15 % le risque de covidlong ( et tw. suivants).
2️⃣ Le risque de séquelles ↗️ à chaque réinfection
(theconversation.com/reinfection-wi…)
Par conséquent et en l'absence de mise
3/
1/ Après #hydroxychloroquine #fluvoxamine #ivermectine #IEC #paxlovid => l'anticorps contre la COVID-19 #evusheld !
La pandémie de biais temporels immortels continue...
La pandémie de biais temporels immortels continue...
2/Aujourd'hui nous publions dans @CIDJournal
une lettre sur une nouvelle étude observationnelle de l'anticorps covid-19 tixagevimab/cilgavimab #Evusheld.
👇
academic.oup.com/cid/advance-ar…
une lettre sur une nouvelle étude observationnelle de l'anticorps covid-19 tixagevimab/cilgavimab #Evusheld.
👇
academic.oup.com/cid/advance-ar…
3/ Cette étude de cohorte rapporte une diminution du risque d'infarctus du myocarde, d'arythmie ou d'insuffisance cardiaque dans les 30 jours suivant le traitement par tixagevimab/cilgavimab par rapport à la cohorte témoin (risque relatif : 0,84, 0,93, 0,89).
1/ After #hydroxychloroquine #fluvoxamine, #paxlovid = #evusheld !
The pandemic of immortal time bias continues...
@drjohnm @venkmurthy @VPrasadMDMPH @TracyBethHoeg
The pandemic of immortal time bias continues...
@drjohnm @venkmurthy @VPrasadMDMPH @TracyBethHoeg
2/Today we publish in @CIDJournal a letter on a new observational study of the covid-19 antibody tixagevimab/cilgavimab #Evusheld
👇
academic.oup.com/cid/advance-ar…
@VPrasadMDMPH
👇
academic.oup.com/cid/advance-ar…
@VPrasadMDMPH
3/ The cohort study reporting an decrease risk of myocardial infarction, arrhythmia or heart failure in the 30 days after treatment by tixagevimab/cilgavimab compared to the control cohort (relative risk : 0.84, 0.93, 0.89)
1/x 🧵This Friday at 10:30am, we're excited to announce the reboot of the #forgotten500K campaign with an update from the podcasts hosted by @claremenglish, @MarkOak04974342, @NikolaBrigden. Here's the message for 2023 in advance. RT. 👇
2/x "The #forgotten500K are a group of immunocompromised patients who have not been prioritized during the pandemic and are experiencing higher ongoing levels of risk. The group started off as individuals asking for help while still in isolation during the pandemic.
3/x They were speaking as individuals trying their best to be heard virtually, as they were not able to leave their homes and re-enter normal life like everyone else. However, the #forgotten500K patient campaign brought them together, providing support and one voice. amazing
Bonjour Monsieur le ministre de la @Sante_Gouv @FrcsBraun et bonjour à toutes vos équipes, au ministère ou dans les établissements publics concernés.
Vous pourriez nous permettre d'éviter tous un EI majeur, celui de la contamination par le #sarscov2 en fréquentant des lieux de
1/
Vous pourriez nous permettre d'éviter tous un EI majeur, celui de la contamination par le #sarscov2 en fréquentant des lieux de
1/
soins où le masque n'est plus obligatoire.
Nombre de personnes se sachant #vulnérables doivent renoncer à des soins puisqu'être la seule personne masquée dans un environnement mal ventilé / aéré fait courir des risques majeurs notamment aux patients immunodéprimés puisque face
2/
Nombre de personnes se sachant #vulnérables doivent renoncer à des soins puisqu'être la seule personne masquée dans un environnement mal ventilé / aéré fait courir des risques majeurs notamment aux patients immunodéprimés puisque face
2/
au variant désormais dominant #BQ1 et ses déclinaisons l'#Evusheld est en échec (poke @Renalooo notamment).
Les supposés #nonvulnérables, encouragés par la #compol du #vivreavec sous-tendu par l'aberrant #tinquièteitsmild se croient forts et n'ont pas peur de ce rhume.
3/
Les supposés #nonvulnérables, encouragés par la #compol du #vivreavec sous-tendu par l'aberrant #tinquièteitsmild se croient forts et n'ont pas peur de ce rhume.
3/
When will the clinically vulnerable stop being collateral damage, @RishiSunak? When will the #Forgotten500k get the same chance to survive this as everyone else? I need #Evusheld to safely access healthcare and daily life again.
@DHSCgovuk
@SteveBarclay
@andreajenkyns
@DHSCgovuk
@SteveBarclay
@andreajenkyns
(1/7) I've lost so much of myself to shielding. My life has ground to a halt, I'm socially isolated, and the constant trauma of knowing that people have decided that my life is worth less than the inconvenience of wearing a mask, including doctors, is utterly draining.
(2/7) I've had to withdraw from the Uni course that I worked through horrendous illness for years to get onto, because they no longer support remote learning, and treated my reluctance to risk serious illness as anxiety to be 'gotten over'. The stress made me physically ill.
#etcequidevaitarriverarriva
Les patients #quisesavent #vulnérables car nous sommes tous #àrisques dans le contexte d'une infection #sarscov2 ce que la #compol ne permet pas de poser (cf. mes trop nombreux 🧵) ne peuvent plus accéder à leurs soins en santé parce que partout et
1/
Les patients #quisesavent #vulnérables car nous sommes tous #àrisques dans le contexte d'une infection #sarscov2 ce que la #compol ne permet pas de poser (cf. mes trop nombreux 🧵) ne peuvent plus accéder à leurs soins en santé parce que partout et
1/
avec la bénédiction des différents ordres (ici @cnomk) le port du #masque devient facultatif jusque dans les lieux de soins.
Le beau narratif du #vivreavec se heurte au principe de réalité parce que non, les #vulnérables ne peuvent plus vivre puisque les milieux intérieurs sont
2
Le beau narratif du #vivreavec se heurte au principe de réalité parce que non, les #vulnérables ne peuvent plus vivre puisque les milieux intérieurs sont
2
désormais une fabuleuse soupe où les virus se croisent, mutent ... pour leur plus grand bonheur puisque tout le monde s'assoit sur la #recommandation du port du masque ...
Encore un bel exemple de #validisme 😢 cette fois-ci sponsorisé par le @gouvernementFR @Elisabeth_Borne
3/
Encore un bel exemple de #validisme 😢 cette fois-ci sponsorisé par le @gouvernementFR @Elisabeth_Borne
3/
This is a really important paper. Some have said it's a bad news story...
The question is should £1bn have been spent on this drug in 2021 following just a prelim analysis of a much smaller trial...
However, before we start, bravo @ChrisColButler & team👏
papers.ssrn.com/sol3/papers.cf…
The question is should £1bn have been spent on this drug in 2021 following just a prelim analysis of a much smaller trial...
However, before we start, bravo @ChrisColButler & team👏
papers.ssrn.com/sol3/papers.cf…
First, a little on molnupiravir (Lagevrio).
This is a nucleoside drug, or "nuc", originally named EIDD-2801 by scientists at Emory University. It was named Molnupiravir after Thor's hammer, Mjölnir.
Nucs are the building blocks of genetic material, so RNA or DNA. Nucs are a well
This is a nucleoside drug, or "nuc", originally named EIDD-2801 by scientists at Emory University. It was named Molnupiravir after Thor's hammer, Mjölnir.
Nucs are the building blocks of genetic material, so RNA or DNA. Nucs are a well
established class of agents used against RNA viruses as they target a unique feature of these viruses - the RNA dependent RNA polymerase, an enzyme that makes more RNA using RNA as a template. We don't have these in mammalian cells, so the idea is you can target this selectively
1/x Several months ago, @katebingham2 drove the UK pandemic response. She is incredible 🦸♀️- thanks for your insight. But then she finished and something extraordinary happened. The Winter plan to protect the #immunocompromised was quietly dropped....😫 Why does it matter? 🤷🤷♂️🤷♀️
2/x Because it had widespread clinical & academic backing for our 2022 Winter plan. Cohorts were identified & large teams of clinicians worked around the clock to work out which of #immunocompromised who don't have high levels of protection from vaccination could be protected 👩⚕️
3/x This would have put us in line with 32 countries who were protected their #immunocompromised during the Winter months when COVID cases rise. If you don't respond to vaccines 💉, then your risk of hospitalisation, ITU admission & not recovering from COVID is 📈
1/x 🧵 ***NEW RESEARCH 👨🔬 *** About #immunocompromised #forgotten500k #cancer. It's a BIG paper, analysing the global data 🗺️. Answers the question- how big is the issue of absent immune responses following covid vaccines. @BrJCancer by @michaeltilby nature.com/articles/s4141… 💛💚
2/x Why did they do it? Because 1⃣ cancer patients are at high risk from covid 📈 2⃣ Many don't get an immune response to vaccines 💉 3⃣ They wanted to find the scale of the problem 💥. So they decided to go global! 🌐
3/x. The team searched 3065 papers published from the start of vaccination to March 2022. They looked at third dose boosters 💉. They looked across all cancer types. They found 15 studies encompassing 1205 patients🧑🤝🧑. The largest global review 🌍
.@RobertJenrick
Here’s a plan for your ‘trial’ of #Evusheld .. Buy it for the #Forgotten500k NOW, and observe what happens. You’ll soon see how effective it is with Omicron. I’ll sign any release you want.. any disclaimer. You can have all the glory. But an RCT?👇
Here’s a plan for your ‘trial’ of #Evusheld .. Buy it for the #Forgotten500k NOW, and observe what happens. You’ll soon see how effective it is with Omicron. I’ll sign any release you want.. any disclaimer. You can have all the glory. But an RCT?👇
How long would it take? How many would sign up for it? Do you think ppl who’ve been shielding for so long to protect themselves would be willing to risk being given a placebo, knowing they risk death? Be serious.
What you’re proposing is unethical and makes no sense. Wake up!👇
What you’re proposing is unethical and makes no sense. Wake up!👇
P.S. Had to delete previous post on this to get rid of an irksome, poisonous little imp. Apologies to all those who had liked and shared before.
This was one..
This was one..
1/x 🧵Let's talk about cancer patients, #immunocompromised, our UK #forgotten500k and COVID. Here's a incredible article by @EnnalsEthan at the @MailOnline and @DailyMailUK. Full post here 👉 dailymail.co.uk/health/article…. Here's what it reports.....
2/x The father unable to hug his teenage daughter 🫂, a retired nurse 👩⚕️unable to walk down the streets, the heartbreaking stories of the Britons with health conditions that mean they are still in self-isolation, shielding from COVID-19. They are the #immunocompromised ♥️🤎💜💙💚
3/x Imogen Dempsy said "my blood test show I have no protection against COVID-19". There is a drug that would provide protection to those that don't respond to the covid vaccines 😷👍. BUT...Evusheld is only available in the UK only to patients who are willing to pay for it. 😢
This week I spoke to @JamesTGallagher at @BBCRadio4 about what it is like to be #immunocompromised and #shielding from covid for nearly 1000 days.👇
bbc.co.uk/sounds/play/m0…
Here's a 🧵 about why I told my family's story. 1/15 @LUPUSUK @RAIRDA_org #evusheld #Forgotten500k
bbc.co.uk/sounds/play/m0…
Here's a 🧵 about why I told my family's story. 1/15 @LUPUSUK @RAIRDA_org #evusheld #Forgotten500k
I am one of 500k people in the uk who is still #shielding nearly 3 years into the pandemic. We are all #immunocompromised due to #autoimmune diseases, transplants and blood cancers 2/15 @bloodcancer_uk @kidneycareuk @LUPUSUK @RAIRDA_org #Forgotten500k @evusheld4theuk
Like thousands of others, I am not only more vulnerable to severe illness from covid due to my illness #lupus, but I am completely unprotected despite vaccination. As a result I need alternative treatments like #evusheld 3/15 @DHSCgovuk @RobertJenrick @evusheld4theuk
More concerning evidence on BA.4.6.
@NEJM finds today that BA.4.6 produces low antibody titers, including if previously infected with any "omicron," vaxxed, or boosted.
VERY low titers. VERY soon after infection (Mdn 21 days) or booster (Mdn 17 days).
1/3
@NEJM finds today that BA.4.6 produces low antibody titers, including if previously infected with any "omicron," vaxxed, or boosted.
VERY low titers. VERY soon after infection (Mdn 21 days) or booster (Mdn 17 days).
1/3
These antibody findings in NEJM are consistent with the FDA research suggesting the pre-exposure prophylactic #Evusheld my yield 1,000x reduced response against BA.4.6.
It's almost like unmitigated spread lets viruses evolve? 🤣
fda.gov/media/154701/d…
2/3
It's almost like unmitigated spread lets viruses evolve? 🤣
fda.gov/media/154701/d…
2/3
Moral of the BA.4.6 story:
Stock up on high-quality #masks like the 3M N95 Aura 9210 (medium, fits most) or 3M N95 Flex (9105/large or 9105S/small). Better yet, get a @flo_mask (adult and child sizes).
Buy HEPA filters (many) or build #CorsiRosenthalBox's
3/3
Stock up on high-quality #masks like the 3M N95 Aura 9210 (medium, fits most) or 3M N95 Flex (9105/large or 9105S/small). Better yet, get a @flo_mask (adult and child sizes).
Buy HEPA filters (many) or build #CorsiRosenthalBox's
3/3
1/x 🧵 Regarding #Evusheld on Bupa. I am *BEYOND SHOCKED*. If you are immunocompromised with cancer, autoimmune disease, kidney disease or on immunocompromised want COVID protection, you won't get it on the NHS. Your only choice is to go to private healthcare 🏥 #forgotten500k
2/x It feels wrong that if you are #immunocompromised and wealthy 💸, then you will get coronavirus protection, BUT... if you are #immunocompromised and poor 🪙👛, you can't. This is going to cause equality based on how much you earn. This doesn't feel right or British. 🇬🇧
3/x Thanks @EnnalsEthan for unshielding this tactic to have covid protection only in the private, but not NHS. #immunocompromised patients just want to hug loved ones and see family 🫂. Do they have a valid choice? Does health need you to be rich? BIG QUESTIONS. @libdemdaisy
1/x 🧵 Regarding Evusheld on Bupa. It makes me sad that if you are immunocompromised with cancer, autoimmune disease, kidney disease or on immunocompromised want COVID protection, you won't get it on the NHS. Your only choice is to go to private healthcare. 🏥
2/x It feels wrong that if you are #immunocompromised and wealthy 💸, then you will get coronavirus protection, BUT... if you are #immunocompromised and poor 🪙👛, you can't. This is going to cause equality based on how much you earn. This doesn't feel right or British. 🇬🇧
3/x Some hope? Maybe @RobertJenrick has not yet to be tested and maybe he might see the right solution here. After all, HEALTH 💪should be for all, COVID PROTECTION 🧑🚀should be for all, COMPASSION should be for all 🫂. This ad from today now seems much most apt👇👇🙁😢
1/ A 🧵- I support the #Forgotten500k who are being denied the lifesaving treatment #Evusheld. Please read my previous thread for more background @RobertJenrick @theresecoffey @Jeremy_Hunt @DHSCgovuk @evusheld4theuk @APPG_VGP
2/ The immunocompromised continue to be denied access to this treatment despite compelling clinical evidence and supporting data, and extensive support from clinicians and patient support groups. There is fantastic advocacy for the use of #Evusheld from @drlennardlee
3/ @libdemdaisy recently raised this issue in Parliament (thank you) and one of the reasons @RobertJenrick gave for not procuring Evusheld for the immunocompromised is that it might give them a false sense of security and cause them to change their behaviours. Yes seriously!
1/x 🧵 ***NEW RESEARCH *** from @EdinburghUni. The paper is relevant for the #immunocompromised and #evusheld and #forgotten500k. It really acts as a WAKE UP & ACT call. It a good paper. thelancet.com/journals/lance…
2/x What's the background? The pandemic continues. 👾Some people are at excess risk and can't hug loved ones, see family or enter normal life 😢. We all believe they are the #immunocompromised, but what does the data show? 💻
3/x This data looked at 16 208 600 vaccined individuals across England🏴, Scotland🏴, Ireland 🇮🇪 and Wales 🏴. i.e. EVERYONE. From Dec 8, 2020, and Feb 28, 2022, so it includes the OMICRON ERA, so relevant. Risk was very carefully defined.
1/x 🧵Worried to be thrown into a big Berlin protest #whs2022. I am here for #immunocompromised patients and learn about better covid prevention. Now there’s protester glued to the buildings, shouting 😡 at the 3500 conferences attendees about climate change. Police have arrived.
2/x This all is not good. Global collective approaches are essential. People must talk. Leaders must talk. Then there should be action. When people don’t feel there is transparency and have to protest, something has gone DEEPLY wrong.
3/x There must be DEEP trust and transparency in leaders. We must bring the public with us and explain the pros and cons. There should not be closed doors. These are key messages that the @IAPartnership are pushing and trained us to deliver. Protests=failure
1/x 🧵 I was thrilled to be talk to @Chikwe_I, WHO assistant Director-General of Health Emerrgency intelligence at @WorldHealthSmt. We talked about protecting #immunocompromised. As an global leader, he had insight about working at system interfaces for change. #incrediblesummit
2/x. He talked about how systems must learn & maintain learning. He talked about a lot of the new talent and expertise generated, particularly entrenching change. He talked about @PeterHorby & other oxford wins, like vaccination. I couldn't believe Oxford had such global reach.
3/x. He was also very gracious with me. I explained the #forgotten500k plan to protect UK immunocompromised patients. He notes that protecting the #immunocompromised and those with cancer who don't respond to #vaccination is a global issue. I told him about antibody therapies.
1 @JNkengasong is a key global leader on public health, Special Representative for Global Health Diplomacy & prev. director of Africa CDC. He led Africa's COVID-19 response. He was awarded the @virchowprize and was generous with his time . This is what I learnt #forgotten500k
2/x He said it is important to raise awareness of COVID-19. Many are suffering & people are still being hospitalisation & not recovering from it. 🧐 Health advocacy is important 💪. You must speak truth 🔊, use expertise, work for patients to appropriately lead emergency plans.
3/x He said it is important to acknowledge that we stand on the shoulders of giants, but it is also important for the new generation of health scientists 🧪 to show the way forwards when there are new ideas that can help and where there is experience. 🙂. His career showed this.
