Discover and read the best of Twitter Threads about #Clostridium
Most recents (3)
Weekend Digest
Name the pathogen
5 Clues
Gram-positive bacillus.
Spore.
Food. Wound. Iatrogenic.
Drooping eyelids.
Preserved sensory function.
Name the pathogen
5 Clues
Gram-positive bacillus.
Spore.
Food. Wound. Iatrogenic.
Drooping eyelids.
Preserved sensory function.
2/
#Clostridium #botulinum
Spore-forming Gram-positive bacillus
Ubiquitous: vegetable, soil, seafood
Neurotoxin: A-H (A, B, E cause human disease)
Toxin binds to receptor in presynaptic terminal —> blocks neurotransmitter release (blocks cholinergic neuromuscular innervation)
#Clostridium #botulinum
Spore-forming Gram-positive bacillus
Ubiquitous: vegetable, soil, seafood
Neurotoxin: A-H (A, B, E cause human disease)
Toxin binds to receptor in presynaptic terminal —> blocks neurotransmitter release (blocks cholinergic neuromuscular innervation)
3/
#Botulism (epidemiologic clues)
1. Infant botulism (raw honey)
2. Foodborne (preformed toxin; home-canned fermented food)
3. Wound botulism (IDU/ black tar heroin)
4. Iatrogenic (cosmetic use)
5. Bioterrorism (mass poisoning)
#Botulism (epidemiologic clues)
1. Infant botulism (raw honey)
2. Foodborne (preformed toxin; home-canned fermented food)
3. Wound botulism (IDU/ black tar heroin)
4. Iatrogenic (cosmetic use)
5. Bioterrorism (mass poisoning)
#MayoIDQ 69M was brought to the ED because of weakness. PE: intoxicated disheveled man with multiple skin ulcers / excoriations.
WBC 27. CK 1486. AST 76.
Wound culture: Clostridium botulinum
Which of the following is most consistent with wound botulism?
WBC 27. CK 1486. AST 76.
Wound culture: Clostridium botulinum
Which of the following is most consistent with wound botulism?
2/
#Botulism
#Botulinum neurotoxin binds to cholinergic nerve terminals and cleaves intracellular proteins needed for #acetylcholine release —> reduced acetylcholine —> neuromuscular blockade —> bulbar palsies, hypotonia, and symmetric, descending, #flaccid #paralysis.
#Botulism
#Botulinum neurotoxin binds to cholinergic nerve terminals and cleaves intracellular proteins needed for #acetylcholine release —> reduced acetylcholine —> neuromuscular blockade —> bulbar palsies, hypotonia, and symmetric, descending, #flaccid #paralysis.
3/
#Botulism
Clinical features
1. Flaccid paralysis
2. Prominent cranial nerve palsies
3. Descending progression
4. Symmetrical presentation
5. No sensory nerve dysfunction.
43% are correct in MCQ
cdc.gov/botulism/healt…
#Botulism
Clinical features
1. Flaccid paralysis
2. Prominent cranial nerve palsies
3. Descending progression
4. Symmetrical presentation
5. No sensory nerve dysfunction.
43% are correct in MCQ
cdc.gov/botulism/healt…
#IdBoardReview 65 M presents w/ severe pain in leg for few hours, progressed to rapid swelling/bullae and +gas on X-ray. hx of bright blood per rectum for few months. diagnosis? #idmedEd #medEd
#Clostridium septicum spontaneous non-traumatic gas gangrene associated with malignancy likely colorectal CA in this case
Spontaneous traumatic gas gangrene is most commonly due to Clostridium perfingens & sometimes other clostridia sp. Non-traumatic spontaneous gas gangrene: most commonly due to C septicum: 80% malignancy related, most common CA are colon f/b hematologic
