Discover and read the best of Twitter Threads about #CardioRenal
Most recents (22)
📌#Cardiorenal Syndrome
Pathophysiology as a key to the therapeutic approach
#CardioTwitter #CardioEd #NephroTwitter #Review
Pathophysiology as a key to the therapeutic approach
#CardioTwitter #CardioEd #NephroTwitter #Review
Management & therapeutic approach📝
1a) Welcome to one of our favorite events on the @academiccme #accredited #tweetorial feeds: a takeover of our programming from @GoggleDocs! The focus of this tweetorial is data from #ADA2022 on #SGLT2i beyond cardiac disease. Our expert author is @GoggleDocs' @drpatrickholmes.
1b) Check out our other #ADA2022 recap #tweetorial by new @GoggleDocs family member @Ines_VFonseca who focused on the cardiac data presented: ckd-ce.com/dkd13_ada22a/
2) This program is #accredited for CE/#CME #physicians #physicianassociates #nurses #pharmacists #nursepractitioners & is supported by an educational grant from the Boehringer Ingelheim Pharmaceuticals Inc and Eli Lilly Company. It is intended for healthcare professionals.
1) Welcome to our new #accredited #tweetorial which is Part 2 of a 2-part "highlights" program on new #SGLT2i & #DKD data presented at @ERAkidney #ERA22. #Physicians #nurses #pharmacists #PAs and #NPs can all earn 0.5h CE/#CME by following this 🧵!
2a) @ERAkidney #ERA22 is a primary international scientific symposium for interaction and exchange among basic scientists and clinicians working in #Nephrology. Our expert author is Dr. Clara García Carro (@ClaraGCarro) from San Carlos Clinical Hospital (Madrid, Spain).
2b) Be sure to check out the first half of this #ERA22 recap from my colleague @shbermejo, and get MORE 🆓CE/#CME at ckd-ce.com/dkd12_ERA22a/. Join me in following @ckd_ce for the BEST in #cardiorenal education delivered entirely by #tweetorial!
1) Welcome to our new #accredited #tweetorial which is Part 1 of a 2-part "highlights" program on new #SGLT2i & #DKD data presented at @ERAkidney #ERA22. #Physicians #nurses #pharmacists #PAs and #NPs can all earn 0.5h CE/#CME by following this thread!
2) @ERAkidney #ERA22 is a primary international scientific symposium for interaction and exchange among basic scientists and clinicians working in #Nephrology. It was held in May. Our expert author is Dr. Sheila Bermejo (@shbermejo) from @vallhebron in Barcelona, Spain.
3) This program is #accredited for CE/#CME & is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance. It is not intended for US- or UK-based based HCPs. Accreditation statement & faculty disclosures at ckd-ce.com/disclosures/.
1) Welcome to a new #accredited #tweetorial on optimizing the role of the pharmacist in managing cardiometabolic disease! Accredited for 0.50 hr for #physicians #nurses #pharmacists! Expert faculty is Snehal Bhatt PharmD @SnayCardsPharmD of @BIDMChealth.
2a) This educational activity is supported by grants from Bayer, Otsuka, & Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company. See archived programs, all by expert authors, still available for credit at ckd-ce.com.
2b) Accreditation statement and faculty disclosures are at ckd-ce.com/disclosures/. We are your ONLY source for accredited education in CKD and #cardiorenal disease delivered wholly on Twitter. FOLLOW US!
Results of the randomized #ADVOR trial are soon coming your way! It's the largest diuretic trial in acute #heartfailure ever conducted (N=519) and will test acetazolamide on top of loop diuretics. Recruitment is finished and full database lock is anticipated. Find out more (1/9).
Appropriate and thorough decongestion is class I recommendation in HFA-ESC guidelines (2/9).
academic.oup.com/eurheartj/arti…
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR #HeartFailure2022 #HFA_ESC
academic.oup.com/eurheartj/arti…
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR #HeartFailure2022 #HFA_ESC
Only 15% of AHF included in DOSE trial were decongested after 72 hours of high-dose loop diuretic (LD) therapy (3/9).
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10…
1) Welcome to a new #accredited #tweetorial on Cardiorenal Disease in T2D & the Impact of Blocking the MR in Patients w/DKD, another CE/#CME program by one of the @GoggleDocs, this time our friend @AmarPut, Diabetes & Endocrine Consultant in the West Midlands 🇬🇧. #CaReMe #FOAMed
2) This program is supported by an educational grant from Bayer & is intended for #healthcare providers. Author disclosures can be found at ckd-ce.com/disclosures/. Prior programs, still available for CE/#CME credit, are at ckd-ce.com. CE/#CME credit 🇬🇧🇪🇺🇨🇦🇺🇸
3) So first – the ‘triple threat’ . . . We know of the link between the 🫀 and the kidneys and the ‘#cardiorenal’ syndrome, but what about in the setting of #diabetes?
What to do if the eGFR drops from 50 to 42 ml/min/m2 during decongestive therapy in acute #HeartFailure ?
Short #Tweetorial on worsening renal function (WRF) (1/9).
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR #HeartFailure2022 #HFA_ESC
Short #Tweetorial on worsening renal function (WRF) (1/9).
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR #HeartFailure2022 #HFA_ESC
There is an underappreciated risk of poor outcome in heart failure patients discharged with ongoing congestion and WRF (2/9).
Pivotal paper of @MarcoMetra ahajournals.org/doi/10.1161/ci…
Pivotal paper of @MarcoMetra ahajournals.org/doi/10.1161/ci…
Appropriate and thorough decongestion is class I recommendation in HFA-ESC guidelines so DON'T stop decongestive efforts during WRF (3/9).
academic.oup.com/eurheartj/arti…
academic.oup.com/eurheartj/arti…
Which statement is correct with regards to the use of diuretics in #HeartFailure with congestion?
Short #Tweetorial on how to use diuretics in heart failure (1/9).
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR #HeartFailure2022 #HFA_ESC
Short #Tweetorial on how to use diuretics in heart failure (1/9).
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR #HeartFailure2022 #HFA_ESC
Door to ‘diuretic’ time: earlier administration of loop diuretics is associated with improved outcomes independent of HF severity (2/9).
jacc.org/doi/abs/10.101…
jacc.org/doi/abs/10.101…
The first dose of the loop diuretic should be 40 mg furosemide (=1 mg bumetanide) in diuretic naïve and twice the home dose in patients on loop diuretic (3/9).
1/10. Wat is the most important driver of worsening renal function in #HeartFailure ?
Look at #Tweetorial on central hemodynamic derangements in heart failure
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR
Look at #Tweetorial on central hemodynamic derangements in heart failure
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR
2/10. The kidney is a remarkable vascular organ. Renal blood flow = 1000 ml/min, renal plasma flow = 600 ml/min.
3/10. Elevated central venous pressure affects renal function significantly more than reduced cardiac output in heart failure. jacc.org/doi/10.1016/j.…
1/ Nephrologists & cardiologists might agree on 1 #NephMadness region: #CardioRenal
Matchup 1:
Diuretic resistance mechanisms vs treatment
ajkdblog.org/2022/03/01/nep…
So many diuresis roadblocks, summarized below by @hellokidneyMD
@DrFlashHeart @NishaKidneyDoc @HeartDocSadiya
Matchup 1:
Diuretic resistance mechanisms vs treatment
ajkdblog.org/2022/03/01/nep…
So many diuresis roadblocks, summarized below by @hellokidneyMD
@DrFlashHeart @NishaKidneyDoc @HeartDocSadiya
2/
Loop diuretics have an S-shaped dose-response curve
ajkdblog.org/2022/03/01/nep…
#NephMadness #CardioRenal @kidney_boy
Loop diuretics have an S-shaped dose-response curve
ajkdblog.org/2022/03/01/nep…
#NephMadness #CardioRenal @kidney_boy
3/
#CardioRenal Matchup 2:
♥️ biomarkers in #CKD vs 🥔 biomarkers in ♥️ disease
NT-proBNP, BNP, & troponin degradation products are filtered through the glomerulus
ajkdblog.org/2022/03/01/nep…
#NephMadness @DrFlashHeart
#CardioRenal Matchup 2:
♥️ biomarkers in #CKD vs 🥔 biomarkers in ♥️ disease
NT-proBNP, BNP, & troponin degradation products are filtered through the glomerulus
ajkdblog.org/2022/03/01/nep…
#NephMadness @DrFlashHeart
Tweet: renal sodium avidity in #HeartFailure
Do you ever wonder what is happening in the kidney in Heart Failure patients? Here’s a short #Tweetorial on renal physiology in HF (1/6).
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR
Do you ever wonder what is happening in the kidney in Heart Failure patients? Here’s a short #Tweetorial on renal physiology in HF (1/6).
#Cardiotwitter #Cardiology #FOAMed #Cardiorenal #MedEd #MedTwitter #Nephrology #ADVOR
Glomerulus: renal blood flow ↓ in HF, but the kidney tries to maintain GFR by afferent arteriolar vasodilation and efferent arteriolar vasoconstriction. This leads to single-nephron hyperfiltration initially preserving total GFR, but further damaging the glomerulus. (2/6)
Proximal tubules: hyperfiltration leads to ↑ water and solutes filtered, but ↓ remaining in the peritubular capillaries. Due to ↑ peritubular capillary oncotic pressure + ↑ renal lymph flow -> ↑ water and Na+ reabsorption in the proximal tubules (3/6)
Mineralocorticoid receptor (MR) has a role in:
👉 BP regulation
👉 Electrolyte Homeostasis
Overactivation of MR leads to:
👉 Inflammation and Fibrosis
👉 Sodium retention
#KidneyWk #Nephpearls #Cardiorenal
👉 BP regulation
👉 Electrolyte Homeostasis
Overactivation of MR leads to:
👉 Inflammation and Fibrosis
👉 Sodium retention
#KidneyWk #Nephpearls #Cardiorenal
Finerenone: potent and selective non-steroidal MR antagonist (MRA) that is distinct from steroidal MRAs
#KidneyWk #Nephpearls #Cardiorenal
#KidneyWk #Nephpearls #Cardiorenal
FIDELITY pre-specified pooled analysis
👉 FIDELIO-DKD
👉 FIGARO-DKD
#KidneyWk #Nephpearls #Cardiorenal
👉 FIDELIO-DKD
👉 FIGARO-DKD
#KidneyWk #Nephpearls #Cardiorenal
Role of chloride in AKI from @ThepHunClub @scoca1 #Nephpearls
👉🏼 journals.physiology.org/doi/pdf/10.115…
👉🏼 journals.physiology.org/doi/pdf/10.115…
In CKD patients, higher serum chloride was associated with a modestly steeper rate of eGFR decline, and may be a useful biomarker to predict CKD progression (ca. 2020) #Nephpearls
👉🏼 bmcnephrol.biomedcentral.com/track/pdf/10.1…
👉🏼 bmcnephrol.biomedcentral.com/track/pdf/10.1…
Serum chloride is strongly & independently asso. w/ worsened survival in patients w/ chronic heart failure (ca. 2016) from @HotSaltsRock @methodsmanmd @KidneydrChirag
#Nephpearls #Cardiorenal
👉🏼 ncbi.nlm.nih.gov/pmc/articles/P…
#Nephpearls #Cardiorenal
👉🏼 ncbi.nlm.nih.gov/pmc/articles/P…
Thursday mornings at #iqraakidneyclub: Excellent short lecture by Dr Vinugopal on the use of Peritoneal Dialysis in Heart Failure/Cardiorenal Syndromes
Sharing a few slides below:
@hafeeq_benil @drferoz @ranji72 @JyotishGopinat2
#NephTwitter #cardiorenal
Sharing a few slides below:
@hafeeq_benil @drferoz @ranji72 @JyotishGopinat2
#NephTwitter #cardiorenal
How frequent have you started PD for refractory heart failure or CRS type 2?
Starting with the basics -- the classification (which always confuses me btw)
1 & 2 being primarily cardiac, 3 & 4 being primarily renal
1 & 3 being acute, 2 & 4 being chronic
1 & 2 being primarily cardiac, 3 & 4 being primarily renal
1 & 3 being acute, 2 & 4 being chronic
Empagliflozin in Heart Failure: Diuretic and Cardio-Renal Effects
#VisualAbstract by @drM_sudha and @docanjuyadav
#NephJC #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
👉🏼 ahajournals.org/doi/pdf/10.116…
#VisualAbstract by @drM_sudha and @docanjuyadav
#NephJC #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
👉🏼 ahajournals.org/doi/pdf/10.116…
Class effects of SGLT2 inhibitors on #cardiorenal outcomes ca. 2019 from @BioMedCentral @McCulloughBHVH #Nephpearls #NephJC
👉🏼 cardiab.biomedcentral.com/articles/10.11…
👉🏼 cardiab.biomedcentral.com/articles/10.11…
Diabetes and Kidney Disease: SGLT2 Inhibitors by @ChristosArgyrop in the August 2019 issue of @KidneyNews #Nephpearls #NephJC
👉🏼 asn-online.org/publications/k…
👉🏼 asn-online.org/publications/k…
Permissive AKI in the treatment of heart failure ca. 2019 from @Kidney_Int @scoca1 @KidneydrChirag
#Nephpearls #Cardiorenal
👉🏼 kidney-international.org/article/S0085-…
#Nephpearls #Cardiorenal
👉🏼 kidney-international.org/article/S0085-…
We do not yet know whether stopping RAAS blockade in stage 4 or 5 CKD improves outcomes ... await @STOPACEi_trial findings
📌 One of the controversies raised during #KDIGOBPinCKD 🇬🇧 meeting #Nephpearls
👉🏼 kdigo.org/wp-content/upl…
📌 One of the controversies raised during #KDIGOBPinCKD 🇬🇧 meeting #Nephpearls
👉🏼 kdigo.org/wp-content/upl…
McCULLOUGH: Pathophysiology of #Cardiorenal Syndrome
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 omicsonline.org/pdfdownload.ph…
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 omicsonline.org/pdfdownload.ph…
Changes in AKI biomarker concentration over time after renal injury from @CJASN #Cardiorenal
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 cjasn.asnjournals.org/content/clinja…
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 cjasn.asnjournals.org/content/clinja…
Conceptual model of Cardiac Surgery Associated AKI (CSA-AKI) #Cardiorenal
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 onlinejacc.org/content/accj/6…
#37VicenzaCourse 🇮🇹 #Nephpearls
👉🏼 onlinejacc.org/content/accj/6…
CREDENCE: Canagliflozin reduces the risk of kidney failure or death due to CV or kidney disease by 30% compared to current standard of care ca. 2019 from @NEJM
#VisualAbstract by @brendonneuen
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
#VisualAbstract by @brendonneuen
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
CREDENCE: Summary of Key Renal and CV Outcomes from @gbakris
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
Whether the increased risk of lower limb amputation in the CANVAS Program was due to differing trial populations or protocols, or to chance remains unclear
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
SZERLIP: Pathologic sequelae of fluid overload in organ systems #Cardiorenal #NKFClinicals 🇺🇸 #Nephpearls
👉🏼 nature.com/articles/nrnep…
👉🏼 nature.com/articles/nrnep…
Relationship between fluid overload and inflammatory biomarkers ca. 2018
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 karger.com/Article/Pdf/48…
#NKFClinicals 🇺🇸 #Nephpearls
👉🏼 karger.com/Article/Pdf/48…
Endothelial glycocalyx determines vascular permeability ca. 2013 from @NEJM #NKFClinicals 🇺🇸 #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
👉🏼 nejm.org/doi/pdf/10.105…
A basic science view of AKI biomarkers ca. 2014 from @NDTsocial
#KDIGOAKI 🇮🇹 #Nephpearls
👉🏼 ncbi.nlm.nih.gov/pmc/articles/P…
#KDIGOAKI 🇮🇹 #Nephpearls
👉🏼 ncbi.nlm.nih.gov/pmc/articles/P…
Proposed utilization of biomarkers in AKI: The combined use of markers of tissue function and pathology would allow patients to be profiled into one of the four quadrants ca. 2014 from @NatRevNeph #KDIGOAKI 🇮🇹 #Nephpearls
👉🏼 nature.com/articles/nrnep…
👉🏼 nature.com/articles/nrnep…
SGLT2 Inhibitors and Cardiorenal Outcomes in the February 2019 issue of @KidneyNews
#ISNWCN 🇦🇺🦘 #Nephpearls
👉🏼 kidneynews.org/kidney-news/is…
#ISNWCN 🇦🇺🦘 #Nephpearls
👉🏼 kidneynews.org/kidney-news/is…
EMPA-REG: Empagliflozin, CV outcomes and mortality in Type 2 Diabetes ca. 2015 from @NEJM
#VisualAbstract by @kidney_boy
#ISNWCN 🇦🇺🦘 #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
#VisualAbstract by @kidney_boy
#ISNWCN 🇦🇺🦘 #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
CANVAS: Canagliflozin and CV & Renal events in Type 2 Diabetes ca. 2017 from @NEJM
#VisualAbstract by @kidney_boy
#ISNWCN 🇦🇺🦘 #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
#VisualAbstract by @kidney_boy
#ISNWCN 🇦🇺🦘 #Nephpearls
👉🏼 nejm.org/doi/pdf/10.105…
