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1) Welcome to our #accredited #tweetorial on clinical trial results and emerging data for treatment of Diabetes and CKD #DM in #CKD. I am Brian Rifkin MD, @brian_rifkin, from the Hattiesburg Clinic. #Nephtwitter #Medtwitter #FOAMed 
2) This #accredited #tweetorial series on #kidneydisease #CKD is supported by an independent educational grant from the Boehringer Ingelheim/Lilly Alliance. It is not intended for US- or UK-based HCPs. Accreditation statement & faculty disclosures at ckd-ce.com/disclosures/.
3) This activity is accredited for #physicians #physicianassociates #nurses #NPs #pharmacists. Prior programs in this series, still eligible for CE/#CME, can be accessed at ckd-ce.com. FOLLOW US to learn from expert faculty!
1) Welcome to our new #accredited #tweetorial which is Part 2 of a 2-part "highlights" program on new #SGLT2i & #DKD data presented at @ERAkidney #ERA22. #Physicians #nurses #pharmacists #PAs and #NPs can all earn 0.5h CE/#CME by following this 🧵!
2a) @ERAkidney #ERA22 is a primary international scientific symposium for interaction and exchange among basic scientists and clinicians working in #Nephrology. Our expert author is Dr. Clara GarcĂa Carro (@ClaraGCarro) from San Carlos Clinical Hospital (Madrid, Spain).
2b) Be sure to check out the first half of this #ERA22 recap from my colleague @shbermejo, and get MORE 🆓CE/#CME at ckd-ce.com/dkd12_ERA22a/. Join me in following @ckd_ce for the BEST in #cardiorenal education delivered entirely by #tweetorial!
New in @JACCJournals w @JJheart_doc on intersection of biomarkers & #SGLT2i in #T2D.
Canagliflozin in #CANVAS
⤵️hs-cTnT & sST2 out to 6yrs
⤵️HF & kidney outcomes irrespective of baseline biomarkers
⤵️MACE particularly in those w multiple abnormal markers
jacc.org/doi/10.1016/j.…
Canagliflozin in #CANVAS
⤵️hs-cTnT & sST2 out to 6yrs
⤵️HF & kidney outcomes irrespective of baseline biomarkers
⤵️MACE particularly in those w multiple abnormal markers
jacc.org/doi/10.1016/j.…
1/ Antiepileptic drugs: a constantly evolving frontier- like many other fields in #Neurology. It’s hard to know about every single medication in-depth. Here, I attempted to make AEDs simple, easy to understand and a handy layout of important facts to know about #AED #epilepsy.
2/ Let’s begin with understanding what is synapse and how it works, then only we can understand how the AEDs work. Look at the cartoon I created from references (acknowledged at the end) with help of an amazing app #Procreate. I’m a fan of @PeterMLawrence1 great art work !!
3/ Looks chaotic?Let’s break it down. You got this!
There are 2 main types of synapses.
A)Excitatory synapse-neurotransmitter is Glutamate- receptors are AMPA and NMDA
B)Inhibitory synapse-neurotransmitter is GABA-receptor is GABAa binding site on ligand gated Cl- channel
There are 2 main types of synapses.
A)Excitatory synapse-neurotransmitter is Glutamate- receptors are AMPA and NMDA
B)Inhibitory synapse-neurotransmitter is GABA-receptor is GABAa binding site on ligand gated Cl- channel
A tweetorial.
Here's an intriguing analysis just published in Diabetes Care by the great folks at @AmDiabetesAssn and @ADA_Journals. We examined concentrations of insulin-like growth factor binding protein-7 (IGFBP7) at BL and 1Y in the CANVAS study.
care.diabetesjournals.org/content/early/…
1/
Here's an intriguing analysis just published in Diabetes Care by the great folks at @AmDiabetesAssn and @ADA_Journals. We examined concentrations of insulin-like growth factor binding protein-7 (IGFBP7) at BL and 1Y in the CANVAS study.
care.diabetesjournals.org/content/early/…
1/
Why IGFBP7? Good question.
Though IGFBP7 "looks like" an IGF binder, it is lousy at this job. But IGFBP7 has other roles: it is a cell cycle arrest biomarker in the 'senescence associated secretory phenotype'.
When cells are exposed to IGFBP7 in excess, fibrosis follows.
2/
Though IGFBP7 "looks like" an IGF binder, it is lousy at this job. But IGFBP7 has other roles: it is a cell cycle arrest biomarker in the 'senescence associated secretory phenotype'.
When cells are exposed to IGFBP7 in excess, fibrosis follows.
2/
We previously found IGFBP7 was associated with cardiac structural and functional abnormalities and outcome in patients with heart failure, but we were interested to see how it would act in patients with #T2D, such as those in CANVAS.
Why?
3/
Why?
3/
Dr. Jardine on side effects of SGLT2i. Where is evidence coming from? #Kidneywk
Mostly is coming from CREDECE since it has the largest population of advanced CKD. Side effects are not different across different stages of CKD #Kidneywk
Hypoglycaemia not common, about 1%. DKA is rare (1 case per 1000 users) but real mostly seen in people who require insulin. #kidneywk
#Beirut_explosion #Lebanon Devastating Beirut ammonium nitrate explosion broken down in new animated video independent.co.uk/news/world/mid…
#niet_in_journaal #nieuwsuur #1V #Op1 #bbvpro #NPORadio1 #Lebanon #Israel #Beirut_explosion #freemasonry #deep_state #Canvas
W#niet_in_journaal #nieuwsuur #1V #OP1 #bbvpro #NPORadio1 #Lebanon #Beirut_explosion #Hezbollah timesofisrael.com/israel-tv-hezb…
California's May budget revise is out; one of the first signs of how states might deal with COVID-changed finances. Here is summary:
ebudget.ca.gov/FullBudgetSumm…
ebudget.ca.gov/FullBudgetSumm…
p. 48: "... the number of students seeking to enroll at UC, CSU, and CCC campuses is expected to grow in the coming years. CCCs, in particular, will likely see notable increases because their enrollment tends to rise when economic challenges emerge. "
Adoration of the Christ Child
#Botticelli #Canvas #Print
zazzle.com/adoration_of_t…
#renaissance #art
#Botticelli #Canvas #Print
zazzle.com/adoration_of_t…
#renaissance #art
Botticelli Adoration of the Christ Child Case-Mate iPhone Case zazzle.com/z/pjhjw?rf=238…
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I interrupt the relentless assault on our Mother Earth led by the ruling classes, to bring to your attention to critical information by @Mision_Verdad regarding a new coup attempt underway in Bolivia. This relates to the #Amazon fires media saturation. #NPIC #Imperialism
@Mision_Verdad Capitalism never sleeps. Nor does imperialism.
The original article by @brunosgarzini for @Mision_Verdad:
LA HUELLA DE ESTADOS UNIDOS EN LA INCIPIENTE REVOLUCIĂ“N DE COLORES EN BOLIVIA:
misionverdad.com/columnista/rev…
The original article by @brunosgarzini for @Mision_Verdad:
LA HUELLA DE ESTADOS UNIDOS EN LA INCIPIENTE REVOLUCIĂ“N DE COLORES EN BOLIVIA:
misionverdad.com/columnista/rev…
@Mision_Verdad @brunosgarzini It has been translated into English by @libya360 on the Internationalist website (which everyone should subscribe to).
The U.S. Footprint in Bolivia’s Incipient Colour Revolution
libya360.wordpress.com/2019/08/30/the…
The U.S. Footprint in Bolivia’s Incipient Colour Revolution
libya360.wordpress.com/2019/08/30/the…
Sir Launcelot in the Queen's Chamber
Dante Gabriel Rossetti
Pen with black and brown #ink #drawing on paper, 1857
zazzle.com/launcelot_in_q…
Dante Gabriel Rossetti
Pen with black and brown #ink #drawing on paper, 1857
zazzle.com/launcelot_in_q…
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Proserpine
Dante Gabriel #Rossetti custom Glossy #Poster
zazzle.com/proserpine_dan…
#preraphaelite #art
Dante Gabriel #Rossetti custom Glossy #Poster
zazzle.com/proserpine_dan…
#preraphaelite #art
Self-Portrait with Beret and Turned-Up Collar
#Rembrandt van Rijn #Canvas #Posters
zazzle.com/self_portrait_…
#Rembrandt van Rijn #Canvas #Posters
zazzle.com/self_portrait_…
Salutation of Beatrice
Dante Gabriel Rossetti, oil on canvas, 1880-1882
zazzle.com/salutation_of_…
#PreRaphaelite #art
Dante Gabriel Rossetti, oil on canvas, 1880-1882
zazzle.com/salutation_of_…
#PreRaphaelite #art
Salutation of Beatrice
Dante Gabriel Rossetti, oil on #canvas, 1880-1882
zazzle.com/salutation_of_…
Dante Gabriel Rossetti, oil on #canvas, 1880-1882
zazzle.com/salutation_of_…
Water Willow
Dante Gabriel Rossetti #Canvas #Poster
zazzle.com/water_willow_d…
#art #preraphaelite
Dante Gabriel Rossetti #Canvas #Poster
zazzle.com/water_willow_d…
#art #preraphaelite
#Art of William-Adolphe #Bouguereau
Forgotten master of 19th century classical academic realism
zazzle.com/artpompier?rf=…
#fineart #prints
Forgotten master of 19th century classical academic realism
zazzle.com/artpompier?rf=…
#fineart #prints
#Art of William-Adolphe #Bouguereau
pinterest.com/argentarts/bou…
William-Adolphe Bouguereau, forgotten master of classical academic #realism of the 19th century French Salon
pinterest.com/argentarts/bou…
William-Adolphe Bouguereau, forgotten master of classical academic #realism of the 19th century French Salon
The Nut Gatherers (Les Noisettes)
William-Adolphe #Bouguereau
oil on #canvas, 1882
zazzle.com/nut_gatherers_…
William-Adolphe #Bouguereau
oil on #canvas, 1882
zazzle.com/nut_gatherers_…
Children in a Garden
The Nurse
Mary #Cassatt
zazzle.com/children_in_a_…
#art #painting #impressionism
The Nurse
Mary #Cassatt
zazzle.com/children_in_a_…
#art #painting #impressionism
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Still Life with Oysters, Rummer, Lemon and Silver Bowl
Willem Claeszoon Heda, oil on canvas, 1634
zazzle.com/still_life_wit…
Willem Claeszoon Heda, oil on canvas, 1634
zazzle.com/still_life_wit…
Still Life with Oysters, a Rummer, a Lemon and a Silver Bowl
Willem Claeszoon Heda Glossy #Poster
zazzle.com/still_life_wit…
Willem Claeszoon Heda Glossy #Poster
zazzle.com/still_life_wit…
Thisbe
John William #Waterhouse, oil on canvas, 1909
zazzle.com/thisbe_vintage…
#preraphaelite #painting
John William #Waterhouse, oil on canvas, 1909
zazzle.com/thisbe_vintage…
#preraphaelite #painting
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