Discover and read the best of Twitter Threads about #ASPNFOAM
Most recents (4)
1/ Want to continue the learning streak of #Kidneywk ?
#MedTwitter #NephTwitter, we bring another #ASPNFOAM group tweetorial based on pathology webinar @ASPNeph on T-cell mediated rejection(TCMR) in kidney transplant (Tx)
#MedTwitter #NephTwitter, we bring another #ASPNFOAM group tweetorial based on pathology webinar @ASPNeph on T-cell mediated rejection(TCMR) in kidney transplant (Tx)
2/
Let's start with a vignette! 13 yr M with CAKUT s/p DDKT 6mo ago, p/w with doubling of Cr from 0.7 to 1.5 mg/dl, normal vitals and PE. UA normal. A lot of recent stressors and concern for non-adherence.
Sounds like a familiar scenario?
Let's start with a vignette! 13 yr M with CAKUT s/p DDKT 6mo ago, p/w with doubling of Cr from 0.7 to 1.5 mg/dl, normal vitals and PE. UA normal. A lot of recent stressors and concern for non-adherence.
Sounds like a familiar scenario?
What is the potential cause of graft dysfunction in this patient?
1/This July’s @aspneph pathology webinar was all about pediatric Antineutrophil Cytoplasmic Antibody (ANCA)- associated vasculitis (AAV). Let's kick off this pediatric AAV tweetorial✍️with a quick question #NephTwitter
🤔 What is the role of ANCA antibodies❓
🤔 What is the role of ANCA antibodies❓
2/
✅Diagnostic marker and Pathogenic in nature
▶️ Proteinase-3 (PR3) and Myeloperoxidase (MPO) antigens are sequestered in neutrophil primary granules
▶️ Antigen exposure triggers immune response leading to endothelial activation
linkinghub.elsevier.com/retrieve/pii/S…
✅Diagnostic marker and Pathogenic in nature
▶️ Proteinase-3 (PR3) and Myeloperoxidase (MPO) antigens are sequestered in neutrophil primary granules
▶️ Antigen exposure triggers immune response leading to endothelial activation
linkinghub.elsevier.com/retrieve/pii/S…
3/
Mechanisms
📌Defective neutrophil apoptosis, leading to NETosis
📌Inefficient clearance of PR3/MPO
📌Antimicrobial antibodies cross reacting with PR3/MPO
📌Medication induced
Mechanisms
📌Defective neutrophil apoptosis, leading to NETosis
📌Inefficient clearance of PR3/MPO
📌Antimicrobial antibodies cross reacting with PR3/MPO
📌Medication induced
1/ Hi #NephTwitter #Renal #MedTwitter @ASPNeph radiology webinar this month was Vesicoureteral reflux #VUR and its management.
Let's get going with a poll!
What percentage of children with febrile UTI may end up having VUR?
Let's get going with a poll!
What percentage of children with febrile UTI may end up having VUR?
2/ Answer: up to 30%
This may be an underestimate since many children don't get tested.
[PMID: 9743033] pubmed.ncbi.nlm.nih.gov/9743033/
This may be an underestimate since many children don't get tested.
[PMID: 9743033] pubmed.ncbi.nlm.nih.gov/9743033/
3/ Risk factors for VUR:
⚡️Bowel and bladder dysfunction
⚡️Abnormal urinary tract anatomy
⚡️Younger children and infants
⚡️Girls affected >> boys
⚡️Family history: sibling with VUR ➡️ 25% recurrence risk
Read more 👇
PMID: pubmed.ncbi.nlm.nih.gov/33869117
⚡️Bowel and bladder dysfunction
⚡️Abnormal urinary tract anatomy
⚡️Younger children and infants
⚡️Girls affected >> boys
⚡️Family history: sibling with VUR ➡️ 25% recurrence risk
Read more 👇
PMID: pubmed.ncbi.nlm.nih.gov/33869117
1/Hello everyone! Welcome to this month’s #ASPNFOAM group Tweetorial, featuring BK polyomavirus (BKV) & #BKNephropathy
🚨Spoiler alert: BK does not stand for Burger King🍔. But hopefully this 🧵 has been cooked up to your liking😉.
#Medtwitter #NephTwitter #PedNeph @ASPNeph
🚨Spoiler alert: BK does not stand for Burger King🍔. But hopefully this 🧵 has been cooked up to your liking😉.
#Medtwitter #NephTwitter #PedNeph @ASPNeph
2.1/ So what’s “BK” & why can’t you have it with a side of🍟?
“BK” actually stands for B.K., the initials of the Sudanese🇸🇩 kidney transplant (KT) patient in whom the virus was 1st identified back in 1971! Not that long ago if you think about it 🤔
(PMID: 4104714, 33319201)
“BK” actually stands for B.K., the initials of the Sudanese🇸🇩 kidney transplant (KT) patient in whom the virus was 1st identified back in 1971! Not that long ago if you think about it 🤔
(PMID: 4104714, 33319201)
2.2/Also:
➤BKV is a non-enveloped double-strand DNA virus.
➤Primary infection occurs through respiratory secretions, mainly asymptomatic.
➤It infects urothelial and tubular cells in a non-replicative latent phase.
➤BKV is a non-enveloped double-strand DNA virus.
➤Primary infection occurs through respiratory secretions, mainly asymptomatic.
➤It infects urothelial and tubular cells in a non-replicative latent phase.
