Discover and read the best of Twitter Threads about #ALLERGY
Most recents (21)
I am going to write part of my (unfinished) story about the K to R transition as a woman in medicine and physician scientist in a multi-disciplinary research space in a tumultuous time. I am oversharing to encourage others in a similar š¤#medtwitter #IDTwitter #AIMedEd. /1 of 20
I study #drug #allergy. It was the inferior antibiotic choices we made for people with vague antibiotic allergies during my residency @MGHMedicine @mghmedres that initially gave me the idea. Too often the allergy lists were impeding clinical care. /2 of 20
I hypothesized that drug allergies were a problem -- that penicillin allergies alone were linked to important antibiotic stewardship and public health outcomes. I set off to prove this, and address the burden of unclear drug allergies across populations. /3 of 20
šÆReview @ScienceTM
Allergy: Mechanistic insights into new methods of prevention and therapy
#scicomm #news #Technology #Tech #NewsBreak #Trending #research #science #AcademicTwitter #MedEd #MedTwitter #allergy
Free access
science.org/doi/10.1126/scā¦
Allergy: Mechanistic insights into new methods of prevention and therapy
#scicomm #news #Technology #Tech #NewsBreak #Trending #research #science #AcademicTwitter #MedEd #MedTwitter #allergy
Free access
science.org/doi/10.1126/scā¦
Molecular mechanisms of IgE-mediated allergic disease. 
Molecular mechanisms of tolerance
My kid has #asthma & a severe, life-threatening dairy #allergy. Weāve been fought by @wilcoxprincipal and now @TwinsburgSupt every step of the way to get our child a section 504 plan. I want my kid alive with access to aninhaler, not dead with a law named after him. #disability
This is a story about how school district administration will fight you every step of the way when all you want them to do is comply with the Americans with Disabilities Act (#ADA), #IDEA, or #Rehabilitation Act. Itās a story about intentional delay and confusion they sow.
First, the schoolās principal Mrs. Villa Turner and school nurse tried to talk us out of a 504 plan. They discouraged it saying an unenforceable āhealth planā would be sufficient because the staff deals with this all the time and is ātrained.ā More on ātrainedā later.
October is #DysautonomiaAwarenessMonth. Today we are looking at some of the known causes of autonomic dysfunction, and how it is investigated. ā [THREAD]
The cause(s) of #autonomicdysfunction in #EDS and #HSD remains unclear. However, some possible causes include: ā
š§š¾āāļøIncreased blood pooling (e.g., in the legs when standing or around the gut after eating) ā
š©øLow circulating blood volume ā
š§š¾āāļøIncreased blood pooling (e.g., in the legs when standing or around the gut after eating) ā
š©øLow circulating blood volume ā
š Medications with side effects that trigger or make problems worse, auto-immunity (immune responses to the personās own body) ā
š· Too much #histamine in the body (related to #allergy)
ā«ļø Rarely, brainstem or spinal cord restrictionā
š· Too much #histamine in the body (related to #allergy)
ā«ļø Rarely, brainstem or spinal cord restrictionā
Tomorrow is #NationalPenicillinAllergyDay in the US! In advance of that, I will share some of my favorite resources on #penicillin #allergy. Please share these broadly with your networks. We have >30mil Americans to evaluate... let's get started! #NPAD 1/7
@MGHAllergy has hosted a multi-site network called @USdrugallergy since 2017 and we have 7 engaged sites with 1,796 enrolled. On our website usdar.massgeneral.org we have @YouTube videos on #drugallergy and #penicillin allergy and post our latest research findings! 2/7
@AAAAI_org has a penicillin allergy center with easy links to educational videos and infographics. Educate yourself and your patients. Increase awareness with images for social media @allisoncramsey @AutumnGuyer education.aaaai.org/penicillin-allā¦ 3/7
Welcome everyone to our 2nd Pediatric on Squares Board Review Course
We are starting today until the coming 8 days
Hope itāll be helpful and enjoyable course
āļø Note that you still can join and register on the course with accessibility to all recorded session until 27th of August
We are starting today until the coming 8 days
Hope itāll be helpful and enjoyable course
āļø Note that you still can join and register on the course with accessibility to all recorded session until 27th of August
Day 1
2nd session: Keys to Answer MCQs
3rd session: Neonatology review
By: Prof. Abdulrahman Alnemari @aalnemri
#Pediatric #Neonatology #NICU #MCQ
2nd session: Keys to Answer MCQs
3rd session: Neonatology review
By: Prof. Abdulrahman Alnemari @aalnemri
#Pediatric #Neonatology #NICU #MCQ
Scott Morrison made an announcement about reducing PBS Medicines. Trouble is he INCREASED them on Jan 1st, 2022, during a Pandemic
affordablemedicines.com.au/home/ #auspol @Mark_Butler_MP
affordablemedicines.com.au/home/ #auspol @Mark_Butler_MP
Anyone see the Irony here. On the same day Morrison announces cheaper medication and healthcare - He cuts Heart scans, ECGās from #Medicare Rebates. #LNPCutsToHealth
themandarin.com.au/187973-electioā¦
themandarin.com.au/187973-electioā¦
The moment Liberals Distracted Voters, while they Cut #MRIās, sleep apnea, #spinal fusion, skin lesion treatments and #Allergy Testing in 2018.
#LNPHealthCuts @RACGP @gedkearney #Medicare #auspol2022
#LNPHealthCuts @RACGP @gedkearney #Medicare #auspol2022
Hey @JacksonSqMall @BurgerKingCAN when a person places an order for a burger from a fast food restaurant and they specify NO PICKLES OR ONIONS DUE TO #ALLERGY it shouldnāt take 28 minute to get your order and the first time they give EXTRA pickles and onions. (Part 1)
(Part 2) So @BurgerKingCAN remakes it but only removes onions but you need them to remake it a Second time so itās the third sandwich and now this time they forget the cheese on the damn sandwich. If BK had any sense they would close this location for absolute terrible service
(Part 3) Also due to the fact of allergies I need to raise my voice slightly to the point where the manager threatens to have me banned from the mall because you guys are trying have me test out the @HamHealthSci by sending me to the damn hospital
#DoBetter
#DoBetter
1/š§µ Letās learn about Ace inh-induced angioedema
Ā
His lips & tongue swelled up hours after taking a blood pressure med heād been on 10 years - lisinopril.
šWhatās the treatment?
šIs it an allergy?
šWhatās a common thought error?
(Pic w Perm - trigger warning tweets 2 & 4)
Ā
His lips & tongue swelled up hours after taking a blood pressure med heād been on 10 years - lisinopril.
šWhatās the treatment?
šIs it an allergy?
šWhatās a common thought error?
(Pic w Perm - trigger warning tweets 2 & 4)
2/ Angioedema is potentially life-threatening
Ā
Itās very scary to see the tongue & lips swelling up so much and the airway compromised.
The patients are watched in the ICU so that intubation and even tracheostomy can occur emergently if required.
Whatās the Dz Mechanism?
Ā
Itās very scary to see the tongue & lips swelling up so much and the airway compromised.
The patients are watched in the ICU so that intubation and even tracheostomy can occur emergently if required.
Whatās the Dz Mechanism?
3/ Is ACE-inh induced Angioedema an allergy?
Ā
NO! Itās not an IGE mediated allergic reaction.
š„ Pro Tip:
People can get angioedema from allergies, but they would be very itchy, and my patient was not itching at all.
That's because it's mediated by a buildup of bradykinin.
Ā
NO! Itās not an IGE mediated allergic reaction.
š„ Pro Tip:
People can get angioedema from allergies, but they would be very itchy, and my patient was not itching at all.
That's because it's mediated by a buildup of bradykinin.
It has recently been suggested that vaccine boosters might ādesensitizeā an immune system to SARS-CoV-2, Ć” la allergy shots.
Thatās not how allergy shots work ā I know because I prescribe them a lot.
I will elaborate for anyone interested. Letās begin:
1/19
Thatās not how allergy shots work ā I know because I prescribe them a lot.
I will elaborate for anyone interested. Letās begin:
1/19
Say a person is allergic to ragweed. This means when they breathe in ragweed pollen, their body develops an immune reaction ā”ļø allergy symptoms.
2/19
2/19
The ragweed pollen is an otherwise BENIGN object, i.e. it hasnāt directly caused damage to the body. The personās immune response has. A non-allergic person could inhale the same pollen and have ZERO symptoms.
(Iāll explain why the point about damage is important later)
3/19
(Iāll explain why the point about damage is important later)
3/19
āļøFIVE Little Allergy/Immunology Lessons from 5 Big Days on Consults āļø @mghaifellows @MGHAllergy. #Urticaria #Angioedema #vaccine reactions eosinophilia and #drugallergy /1
ONE-To treat acute urticaria (hives), antihistamines should be nonsedating and scheduled (not diphenhydramine PRN). Allegra/fexofenadine and Zyrtec/cetirizine have large therapeutic windows and are used safely at 4+ times the daily allergic rhinitis dose/2
TWO-Angioedema in an adult without skin itching/hives/rashācheck if they on an ACE inhibitor! Although ~10% get it w/in 30d, many happen after years of uneventfully being on it /3 ncbi.nlm.nih.gov/pmc/articles/Pā¦
Starting #UnsungHeroesImmuno. Did you know about Onesimus and his knowledge of variolation? 1/
#UnsungHeroesImmuno What about Dr. William Augustus Hinton and his work with syphilis? 2/
#UnsungHeroesImmuno We also have Drs. Louis Tompkins Wright and Jane Cook Wright, a father-daughter pair that changed the field of oncology. 3/
In this opinion paper @RMedzhitov went back to drawing board to update his views on #allergy and how it could develop.
#immunology
I read this paper and here is my take on it
1/
#immunology
I read this paper and here is my take on it
1/
@RMedzhitov Why focus on allergy? b/c allergy is a paradox. The allergy we recognize is a completely maladaptive response and has no protective role whatsoever. It is not clear why do we even need IgE
2/
2/
@RMedzhitov So, some 10 years ago or so, @RMedzhitov started to suggest that #allergy is an intrinsic property of a certain type of #antigens, many of them with enzymatic function (enzymes). 3/
It has been a busy month learning about #allergy after #COVID19Vaccines but we so excited to receive this broad information from @CDCgov. Highlights below!/1
cdc.gov/mmwr/volumes/7ā¦
cdc.gov/mmwr/volumes/7ā¦
*Potential #anaphylaxis 175 of 1,893,360 1st doses of @pfizer vaccines (0.009%; 90 per million)
*Confirmed #anaphylaxis, 21 of 1,893,360 1st doses of @pfizer vaccines (0.0011%; 11 per million)
-->Better than we thought (1 per 100,000)but greater than usual 1 per million)/2
*Confirmed #anaphylaxis, 21 of 1,893,360 1st doses of @pfizer vaccines (0.0011%; 11 per million)
-->Better than we thought (1 per 100,000)but greater than usual 1 per million)/2
*17 of 21 Anaphylaxis cases (81%) had allergy history; 7 of 21 (33%) had prior anaphylaxis
*Anaphylaxis occurred a median of 13 min (2ā150 min) after vaccination; 71% occurred within 15 min (i.e., CDC recommended waiting/observation time)
*Follow-up for 20 patients & 100% OK /3
*Anaphylaxis occurred a median of 13 min (2ā150 min) after vaccination; 71% occurred within 15 min (i.e., CDC recommended waiting/observation time)
*Follow-up for 20 patients & 100% OK /3
1/Here is @CDCgov guidance for #allergy considerations about the @pfizer and @moderna_tx #COVID19vaccines : cdc.gov/vaccines/covidā¦
#AIMedEd #medtwitter #allergyandimmunologyrocks @ericashenoy
#AIMedEd #medtwitter #allergyandimmunologyrocks @ericashenoy
2/#allergy and #anaphylaxis can happen to any #drug or #vaccine, but reactions to #COVID19vaccine are exceedingly rare (~6 in >300K vaccinations so far--> 0.002%). #vaccines have always been a rare cause of allergic reactions in healthcare.
3/Recently we looked at ~3K allergic reactions in healthcare settings @MassGenBrigham: contrasts caused allergy the most & just 6 vaccine reactions in 10-years. @NeelamPhadkeMD @MGH_ClinEpi @lizhou08 @JieHealthAI @PaigeWickner
pubmed.ncbi.nlm.nih.gov/32959347/
pubmed.ncbi.nlm.nih.gov/32959347/
1/ OK so 1 week after UK #COVID19Vaccine allergy was described, I need to reorient you to my world, the world where #drugallergy is the best field of #MedTwitter #AIMedEd #allergyimmunologyrocks. Let's get down to this confusion about the #covid19vaccine and #allergy
2/ There is no reason to think that anyone -- other than patients with a known allergy to an ingredient in this vaccine or an ingredient cross-reactive to an ingredient in this vaccine -- might have an #allergy the @pfizer #CovidVaccine.
3/ There is even very little that we think could cause an #allergy in this @pfizer vaccine. But 2 patients had #anaphylaxis after vaccination and we need to think about why. Something epidemiologically different in the UK population compared to clinical trial populations?
1/OK so there *may* be new reports of allergy to #COVID19 vaccines but many other things (e.g., vasovagal syncope) can be misdiagnosed as allergy so we need more clinical details from the UK
cnn.com/2020/12/09/heaā¦
cnn.com/2020/12/09/heaā¦
2/ BUT, it is not surprising that allergic reactions might be identified during massive vaccination but not clinical trials because #allergy to vaccines are exceedingly rare (1 per million). In the @US_FDA report, AEs within 30 min for vaccine vs placebo were similar:
3/Most vaccine allergies come from the excipients and allergists can do skin testing to the vaccine and its excipients (often facilitating safe and totally unremarkable vaccination). Excipients are often shared for many approved vaccines: cdc.gov/vaccines/pubs/ā¦
1/ #IDTwitter and #IDFellows, here is another #IDboardreview question: 20F p/w pharyngitis w/fever. There is no cough. Exam: Cervical adenopathy; tonsillar exudate. Rapid Strep antigen test pos. You start to prescribe her Amoxicillin but there is an allergy alert.
2/ She reports an allergic reaction to penicillin around age 8 or 9. She had a rash but no other symptoms. It resolved following discontinuation of med. She did not receive any treatment. Which of the following would you do next?
I had a pretty scary experience last night as a patient that I wanted to share. This story may hit home for #allergy #foodallergy #celiac friends and I hope will be enlightening for my #medtwitter #medstudenttwitter friends! 1/
So my family ordered takeout from a restaurant that Iāve eaten safely at dozens of times in the past. Unfortunately 2 bites into my food, I started to feel nauseous and my lips start tingling.
For anyone with food allergies, you know thatās the start of something bad. 2/
For anyone with food allergies, you know thatās the start of something bad. 2/
That uncomfortable feeling progressed into full blown anaphylaxis very quickly.
Ive made it 28 yrs, never had to use my EpiPen before & I made the huge mistake of not having it with me. I am INCREDIBLY thankful that my partner keeps one for me at all times just in case. 3/
Ive made it 28 yrs, never had to use my EpiPen before & I made the huge mistake of not having it with me. I am INCREDIBLY thankful that my partner keeps one for me at all times just in case. 3/
thread
Remarkable @bmj_latest @BMJCaseReports report documenting the extreme lengths a bedbound patient went through to get a diagnosis of #POTS, #MCAS, #SIBO and #tachycardia
read her story here
#MedEd #MedTwitter @MayoClinic
casereports.bmj.com/content/2018/bā¦
Remarkable @bmj_latest @BMJCaseReports report documenting the extreme lengths a bedbound patient went through to get a diagnosis of #POTS, #MCAS, #SIBO and #tachycardia
read her story here
#MedEd #MedTwitter @MayoClinic
casereports.bmj.com/content/2018/bā¦
2. After suffering for 16 years, seeing 19 docs with repeated misdiagnosis:
Her cardiologist couldnt diagnose #POTS
Her gastroenterologist couldnt diagnose #SIBO
Her immunologist couldnt diagnose #MCAS
Her neurologist referred her to a #psychiatrist!
casereports.bmj.com/content/2018/bā¦
Her cardiologist couldnt diagnose #POTS
Her gastroenterologist couldnt diagnose #SIBO
Her immunologist couldnt diagnose #MCAS
Her neurologist referred her to a #psychiatrist!
casereports.bmj.com/content/2018/bā¦
3. Patient: the "neurologist was out of ideas and suggested I get a psych evaluation, which I declined"
the patient <referred herself> to @MayoClinic
#SickNotWeak #chronicillness #chronicpain #MedEd #medtwitter
casereports.bmj.com/content/2018/bā¦
the patient <referred herself> to @MayoClinic
#SickNotWeak #chronicillness #chronicpain #MedEd #medtwitter
casereports.bmj.com/content/2018/bā¦
1/I've said many times that I am poor because I am unemployed (except for my writing) and I am unemployed because I am disabled.
I am now officially rejecting that shit.
I am still disabled. I still am not employed.
#Disability #ChronicIllness #poverty
I am now officially rejecting that shit.
I am still disabled. I still am not employed.
#Disability #ChronicIllness #poverty
2/But the reason I am unemployed is because society has deemed me disposable. This isn't on me.
#disabled #DisabledPeopleMatter #PplWDisabilitiesMATTER
#disabled #DisabledPeopleMatter #PplWDisabilitiesMATTER
3/It's because society has decided the WANTS of the abled (specifically in my case, to use fragrance and decorate with balloons) are more important than my survival. This isn't on me.
#BanBalloonsInstead #fragrance #MCS #MCAS #allergy #asthma
#BanBalloonsInstead #fragrance #MCS #MCAS #allergy #asthma
