Discover and read the best of Twitter Threads about #anaphylaxis
Most recents (7)
1 of 10 /Do you use an electronic health record? Did anyone ever teach you how to document #allergies? đź‘€Check our this #EHR allergy documentation guidance #medtwitter #idtwitter #AIMedEd @EricMacyMD @AutumnGuyer @allisoncramsey @vumc_cdsi_rsch @JACIInPractice 
2 of 10/We are excited to announce that the adverse reaction to drugs biologics and latex (ARDBL) committee of the @AAAAI_org has an #inpress workgroup report on allergy documentation in the EHR. jaci-inpractice.org/article/S2213-…
3 of 10/ In this article: current state of allergy #ehr documentation, definitions, reconfigurations, and recommendations✔️#bestpractices in documentation for #penicillin allergy ✔️what to include and what not to include in the allergy list
Now this a good ongoing study in South African, #SisonkeStudy .. published in @NEJM .. studying safety data of vaccinated health care workers (HCW), with breakdown of reported adverse effects thus far.. 1/n
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10…
Sample size of HCWs receiving the Ad26. COV2. S #vaccine or the #johnsonandjohnson is very significant !! n = 288,368 .. 2/n
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10…
Results: out of total 288,368 HCWs who received the #johnsonandjohnson #vaccine fr 17th Feb 2021 till 12th Apr 2021.. ONLY 5,898 (2%) reported adverse events.. And even from these 5,898, 4,777 (or 81%) only reported mild to moderate reactogenecity.. 3/n
nejm.org/doi/full/10.10…
nejm.org/doi/full/10.10…
🧵1/ prospective cohort @JAMANetwork >64K employees receiving @pfizer @moderna_tx #CovidVaccine dose 1, 98% had no allergy symptoms, 2% had some allergy symptoms (itching/rash/hives/swelling) & #anaphylaxis occurred 2.47/10K vaccinations. jamanetwork.com/journals/jama/…
2/Allergy symptoms were slightly more with @moderna_tx (2.20% vs 1.95%; p=0.03). Although no difference in #anaphylaxis incidence by vaccine manufacturer, but different #anaphylaxis criteria led to different estimates (Brighton/NIAID/FAAN: from 1.1-2.5/10K administrations).
3/Similar to @CDCgov reports, the 16 #anaphylaxis patients were largely female (94%); 10 (63%) had prior allergy history and 5 (31%) had prior anaphylaxis history. BUT, we estimate that ~4K @MassGenBrigham employees with severe allergy histories were safely vaccinated.
1/ @MGHAllergy @BWHAllergy @vumc_cdsi_rsch #vaccine and #drugallergy experts provide a clear and concise approach to safely evaluate those with a history of #anaphylaxis and anyone with an #allergicreaction reaction to the first dose of @Pfizer or @Moderna #CovidVaccine.
2/ See our updated manuscript @JACIInPractice that includes information on #skintesting using non-irritating skin test concentrations to #PEG and #polysorbate and when to consider #skintesting jaci-inpractice.org/action/showPdf…
3/ The potential life-saving benefit of vaccination makes it essential that we carefully evaluate every possible #allergicreaction to prevent denying access to the vaccine unnecessarily. Our knowledge is rapidly evolving and future recommendations may change with more data.
It has been a busy month learning about #allergy after #COVID19Vaccines but we so excited to receive this broad information from @CDCgov. Highlights below!/1
cdc.gov/mmwr/volumes/7…
cdc.gov/mmwr/volumes/7…
*Potential #anaphylaxis 175 of 1,893,360 1st doses of @pfizer vaccines (0.009%; 90 per million)
*Confirmed #anaphylaxis, 21 of 1,893,360 1st doses of @pfizer vaccines (0.0011%; 11 per million)
-->Better than we thought (1 per 100,000)but greater than usual 1 per million)/2
*Confirmed #anaphylaxis, 21 of 1,893,360 1st doses of @pfizer vaccines (0.0011%; 11 per million)
-->Better than we thought (1 per 100,000)but greater than usual 1 per million)/2
*17 of 21 Anaphylaxis cases (81%) had allergy history; 7 of 21 (33%) had prior anaphylaxis
*Anaphylaxis occurred a median of 13 min (2–150 min) after vaccination; 71% occurred within 15 min (i.e., CDC recommended waiting/observation time)
*Follow-up for 20 patients & 100% OK /3
*Anaphylaxis occurred a median of 13 min (2–150 min) after vaccination; 71% occurred within 15 min (i.e., CDC recommended waiting/observation time)
*Follow-up for 20 patients & 100% OK /3
1/Here is @CDCgov guidance for #allergy considerations about the @pfizer and @moderna_tx #COVID19vaccines : cdc.gov/vaccines/covid…
#AIMedEd #medtwitter #allergyandimmunologyrocks @ericashenoy
#AIMedEd #medtwitter #allergyandimmunologyrocks @ericashenoy
2/#allergy and #anaphylaxis can happen to any #drug or #vaccine, but reactions to #COVID19vaccine are exceedingly rare (~6 in >300K vaccinations so far--> 0.002%). #vaccines have always been a rare cause of allergic reactions in healthcare.
3/Recently we looked at ~3K allergic reactions in healthcare settings @MassGenBrigham: contrasts caused allergy the most & just 6 vaccine reactions in 10-years. @NeelamPhadkeMD @MGH_ClinEpi @lizhou08 @JieHealthAI @PaigeWickner
pubmed.ncbi.nlm.nih.gov/32959347/
pubmed.ncbi.nlm.nih.gov/32959347/
1/ OK so 1 week after UK #COVID19Vaccine allergy was described, I need to reorient you to my world, the world where #drugallergy is the best field of #MedTwitter #AIMedEd #allergyimmunologyrocks. Let's get down to this confusion about the #covid19vaccine and #allergy
2/ There is no reason to think that anyone -- other than patients with a known allergy to an ingredient in this vaccine or an ingredient cross-reactive to an ingredient in this vaccine -- might have an #allergy the @pfizer #CovidVaccine.
3/ There is even very little that we think could cause an #allergy in this @pfizer vaccine. But 2 patients had #anaphylaxis after vaccination and we need to think about why. Something epidemiologically different in the UK population compared to clinical trial populations?
