Discover and read the best of Twitter Threads about #AF2
Most recents (2)
It's finally time to discuss the main highlights of #CASP15's assembly category, where we had these beatiful 41 targets: 
1/6 Can #AlphaFold learn from + & - labeled data to predict peptide binding better? w/ Phil Bradley @JustasDauparas @minkbaek @Mohamad_Abedi David Baker we present joint structure prediction-classification fine-tuning of #AF2 to classify pMHC binding.@UWproteindesign @fredhutch
2/6 We developed a template-based method for accurately predicting pMHC structures & fed confidence scores to a simple classifier to fine-tune with structure+classification loss on a self-distillation set of + and - pMHC interactions & reach SOTA in Class I & II classification.
3/6 We show that our method is potentially orthogonal to NetMHCpan and can correctly label peptides where NetMHCpan fails.
