Discover and read the best of Twitter Threads about #CASP15

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It's finally time to discuss the main highlights of #CASP15's assembly category, where we had these beatiful 41 targets:
Compared to #CASP14, in #CASP15, we have a significant increase in the number of targets offered and in the number of groups participating the challange:
Over these targets, community produced extremely good results, when we consider the interface patch (IPS) and interface contact (ICS) scores. In #CASP15, for almost 50% of the cases, there is at least one high accuracy model generated (ICS>=0.8), which was only 7% in #CASP14.
Read 11 tweets
Some initial results from the #CASP15 competition and we see that #Alphafold2 has become a fertile ground for experimentation by several research groups around the world. Facebook's ESM protein language models (pLMs) are the top non-MSA based methods.
Another slide showing some of the experimentation taking place: increase the number of models, recycles, get more diversity using dropout (how would that work?), subsample MSAs.
A slide showing the amount of #GPU hours used for computing the structures in the #CASP15 dataset.
Read 6 tweets

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