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Never be afraid to raise your voice for honesty and truth and compassion against injustice and lying and greed. William Faulkner
Perpetual Mind Profile picture Tim- #BlueVoterSuperNova -STOP fossil fool antisci Profile picture Crystal Profile picture Bausser Profile picture AAH Profile picture 38 subscribed
May 19 โ€ข 8 tweets โ€ข 3 min read
๐— ๐—ข๐—•๐—œ๐—Ÿ๐—œ๐—ง๐—ฌ ๐—ถ๐˜€ ๐˜๐—ต๐—ฒ ๐—บ๐—ฎ๐—ถ๐—ป ๐—ง๐—ฅ๐—œ๐—š๐—š๐—˜๐—ฅ ๐—ณ๐—ผ๐—ฟ ๐˜๐—ต๐—ฒ ๐—ง๐—ฅ๐—”๐—ก๐—ฆ๐— ๐—œ๐—ฆ๐—ฆ๐—œ๐—ข๐—ก ๐—ข๐—™ ๐—–๐—ข๐—ฉ๐—œ๐——-19 ๐—ฎ๐—ป๐—ฑ ๐—ผ๐˜๐—ต๐—ฒ๐—ฟ ๐—ฟ๐—ฒ๐˜€๐—ฝ๐—ถ๐—ฟ๐—ฎ๐˜๐—ผ๐—ฟ๐˜† ๐˜ƒ๐—ถ๐—ฟ๐˜‚๐˜€๐—ฒ๐˜€ ! Image 2) Even if we regret the use of the word "post-pandemic", it remains a very interesting and key study.
Researchers examined the impacts of human mobility and behavior on the transmission of 18 respiratory viruses (including SARS-CoV-2) in the Seattle area from 2018-2022. Image
May 19 โ€ข 4 tweets โ€ข 2 min read
๐—ช๐—ต๐—ฎ๐˜ ๐—ถ๐˜€ ๐—ฐ๐˜‚๐—ฟ๐—ฟ๐—ฒ๐—ป๐˜ ๐—ฐ๐—ฎ๐—ฟ๐—ฒ ๐—ณ๐—ผ๐—ฟ ๐—ฝ๐—ฒ๐—ผ๐—ฝ๐—น๐—ฒ ๐˜„๐—ถ๐˜๐—ต ๐—Ÿ๐—ผ๐—ป๐—ด ๐—–๐—ข๐—ฉ๐—œ๐—— ๐—ถ๐—ป ๐—˜๐—ป๐—ด๐—น๐—ฎ๐—ป๐—ฑ?

bmjopen.bmj.com/content/14/5/eโ€ฆ
Image 2) This qualitative study explored care for Long COVID in England through interviews with 21 patients and 15 healthcare professionals. Key themes included the complex physical/mental symptoms experienced by patients and highlighted challenges accessing primary care. Image
May 19 โ€ข 5 tweets โ€ข 2 min read
๐—™๐—Ÿ๐—œ๐—ฃ, ๐—™๐—Ÿ๐—œ๐—ฅ๐—ง, ๐—™๐—Ÿ๐—ข๐—ฃ ?

In the fall of 2023, FLIPs appeared with 2 mutations (L455F, F456L).
Then, to use Daniele's beautiful expression @dfocosi, L445F (blue) made a "slip" towards L445S (green) which gave birth to JN.1 Image 2) Beginning 2024, 2 mutations, F456L, R346T gave birth to the "FLIRTs".
Except that these mutations were not new. F456L for example was already in EG.5.1
(๐˜ ๐˜ญ๐˜ฆ๐˜ง๐˜ต ๐˜ต๐˜ฉ๐˜ฆ ๐˜ญ๐˜ฆ๐˜จ๐˜ฆ๐˜ฏ๐˜ฅ ๐˜ข๐˜ต ๐˜ต๐˜ฉ๐˜ฆ ๐˜ฃ๐˜ฆ๐˜จ๐˜ช๐˜ฏ๐˜ฏ๐˜ช๐˜ฏ๐˜จ ๐˜ฐ๐˜ง ๐˜ต๐˜ฉ๐˜ฆ ๐˜จ๐˜ณ๐˜ข๐˜ฑ๐˜ฉ ๐˜ง๐˜ฐ๐˜ณ ๐˜ต๐˜ฉ๐˜ฆ ๐˜ค๐˜ฐ๐˜ญ๐˜ฐ๐˜ณ ๐˜ค๐˜ฐ๐˜ฅ๐˜ฆ๐˜ด) Image
May 18 โ€ข 5 tweets โ€ข 2 min read
๐—”๐—ก๐—ง๐—œ๐—•๐—œ๐—ข๐—ง๐—œ๐—–๐—ฆ ๐—ข๐—ฉ๐—˜๐—ฅ๐—จ๐—ฆ๐—˜ ๐Ÿ˜จ
42.1% ๐—ผ๐—ณ ๐—–๐—ข๐—ฉ๐—œ๐—— ๐—ฃ๐—”๐—ง๐—œ๐—˜๐—ก๐—ง๐—ฆ ๐—ต๐—ฎ๐—ฑ ๐—บ๐˜‚๐—น๐˜๐—ถ๐—ฑ๐—ฟ๐˜‚๐—ด ๐—ฅ๐—˜๐—ฆ๐—œ๐—ฆ๐—ง๐—”๐—ก๐—ง ๐—•๐—”๐—–๐—ง๐—˜๐—ฅ๐—œ๐—” ๐—œ๐—ก๐—™๐—˜๐—–๐—ง๐—œ๐—ข๐—ก๐—ฆ !

(Global systematic review of 173 studies with 892K+ COVID patients) Image 2) This systematic review and meta-analysis of 173 studies with 892,312 COVID-19 patients provided a comprehensive assessment of antimicrobial resistance (AMR) and antibiotic usage during the pandemic. It reported a 42.1% prevalence of multidrug-resistant organism infection ... Image
May 18 โ€ข 6 tweets โ€ข 3 min read
๐—”๐—ฟ๐—ฒ ๐—–๐——8+ ๐—ง ๐—ฐ๐—ฒ๐—น๐—น๐˜€ ๐—ฐ๐—ผ๐—ป๐˜๐—ฟ๐—ถ๐—ฏ๐˜‚๐˜๐—ฒ ๐˜๐—ผ ๐—ถ๐—บ๐—บ๐˜‚๐—ป๐—ผ๐˜๐—ต๐—ฟ๐—ผ๐—บ๐—ฏ๐—ผ๐˜€๐—ถ๐˜€ ๐—ถ๐—ป ๐˜€๐—ฒ๐˜ƒ๐—ฒ๐—ฟ๐—ฒ ๐—–๐—ข๐—ฉ๐—œ๐——-19 ๐—ฝ๐—ฎ๐˜๐—ถ๐—ฒ๐—ป๐˜๐˜€ ๐˜๐—ต๐—ฟ๐—ผ๐˜‚๐—ด๐—ต ๐—ฝ๐—ฟ๐—ผ๐—บ๐—ผ๐˜๐—ถ๐—ป๐—ด ๐—ง๐—ต17 ๐—ฑ๐—ถ๐—ณ๐—ณ๐—ฒ๐—ฟ๐—ฒ๐—ป๐˜๐—ถ๐—ฎ๐˜๐—ถ๐—ผ๐—ป ? Image 2) Th17 differentiation refers to the process by which naรฏve T cells differentiate into Th17 cells.
Activated CD8+ T cells produce IFNy which inhibits Th17 differentiation and limits excessive inflammation and memory CD8+ T cells regulate Th17-dominant immune responses. Image
May 18 โ€ข 4 tweets โ€ข 2 min read
๐™„๐™จ ๐™ฉ๐™๐™š๐™ง๐™š ๐™– ๐™ก๐™ž๐™ฃ๐™  ๐™—๐™š๐™ฉ๐™ฌ๐™š๐™š๐™ฃ ๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™Š๐™‘-2 ๐™‘๐™„๐™๐˜ผ๐™‡ ๐™‡๐™Š๐˜ผ๐˜ฟ ๐™–๐™ฃ๐™™ ๐˜ฟ๐™„๐™Ž๐™€๐˜ผ๐™Ž๐™€ ๐™Ž๐™€๐™‘๐™€๐™๐™„๐™๐™” ? Image 2) This study evaluated the association between SARS-CoV-2 viral load and disease severity in 145 COVID-19 patients using a SARS-CoV-2 Duo assay. Viral load positively correlated with severity and hospital stay duration, highest in severe cases at 8.22 log10 IU/mL on average. Image
May 18 โ€ข 5 tweets โ€ข 2 min read
๐™’๐™๐™ฎ ๐˜ฝ๐™ค๐™ฃ๐™š ๐™ข๐™–๐™ง๐™ง๐™ค๐™ฌ ๐™ฅ๐™ก๐™–๐™จ๐™ข๐™– ๐™˜๐™š๐™ก๐™ก๐™จ (๐˜ฝ๐™ˆ๐™‹๐˜พ) ๐™จ๐™๐™ค๐™ฌ ๐™๐™š๐™ฉ๐™š๐™ง๐™ค๐™œ๐™š๐™ฃ๐™š๐™ž๐™ฉ๐™ฎ ๐™–๐™ฃ๐™™ ๐™™๐™ž๐™›๐™›๐™š๐™ง๐™š๐™ฃ๐™ฉ ๐™–๐™˜๐™ฉ๐™ž๐™ซ๐™–๐™ฉ๐™ž๐™ค๐™ฃ ๐™š๐™ฃ๐™ซ๐™ž๐™ง๐™ค๐™ฃ๐™ข๐™š๐™ฃ๐™ฉ๐™จ ๐™–๐™›๐™ฉ๐™š๐™ง ๐™ซ๐™–๐™˜๐™˜๐™ž๐™ฃ๐™–๐™ฉ๐™ž๐™ค๐™ฃ ? Image 2) In this study, researchers examined the heterogeneity of long-lived antibody-producing plasma cells residing in human bone marrow. Using single-cell RNA sequencing of over 38,000 bone marrow plasma cells, 10 distinct "clans" were identified ...
nature.com/articles/s4146โ€ฆ
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May 18 โ€ข 4 tweets โ€ข 2 min read
๐™„๐™จ ๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™ค๐™‘-2 ๐™ž๐™ฃ๐™›๐™š๐™˜๐™ฉ๐™ž๐™ค๐™ฃ, ๐™– ๐™˜๐™–๐™ช๐™จ๐™š ๐™ค๐™› ๐™ฃ๐™š๐™ช๐™ง๐™ค๐™™๐™š๐™œ๐™š๐™ฃ๐™š๐™ง๐™–๐™ฉ๐™ž๐™ค๐™ฃ ?

(๐˜ธ๐˜ช๐˜ต๐˜ฉ ๐˜—๐˜‹๐˜ ๐˜ง๐˜ช๐˜ญ๐˜ฆ๐˜ด) Image 2) SARS-CoV-2 infection increases risk of neurodegenerative diseases like Alzheimer's and dementia by triggering neuroinflammation and vascular damage, as evidenced by studies linking COVID to later diagnoses. thelancet.com/journals/laneuโ€ฆ
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May 18 โ€ข 4 tweets โ€ข 2 min read
๐™ƒ๐™ค๐™ฌ ๐™ฉ๐™ค ๐™š๐™จ๐™ฉ๐™ž๐™ข๐™–๐™ฉ๐™š ๐™–๐™ž๐™ง๐™—๐™ค๐™ง๐™ฃ๐™š ๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™Š๐™‘-2 ๐™ฉ๐™ง๐™–๐™ฃ๐™จ๐™ข๐™ž๐™จ๐™จ๐™ž๐™ค๐™ฃ ๐™ž๐™ฃ ๐™™๐™–๐™ฎ๐™˜๐™–๐™ง๐™š ๐™ง๐™ค๐™ค๐™ข๐™จ ? Image 2) This study estimated hourly airborne SARS-CoV-2 transmission risk in daycare rooms by calculating inhaled viral doses from occupancy, activities, and aerosol emission/transport models. Risks significantly varied by room and time ... cell.com/heliyon/fullteโ€ฆ
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May 18 โ€ข 4 tweets โ€ข 2 min read
๐˜พ๐™–๐™ฃ ๐™ฌ๐™š ๐™ž๐™ข๐™ฅ๐™ง๐™ค๐™ซ๐™š ๐™‡๐™ค๐™ฃ๐™œ ๐˜พ๐™Š๐™‘๐™„๐˜ฟ ๐™—๐™ฎ ๐™จ๐™ฉ๐™ž๐™ข๐™ช๐™ก๐™–๐™ฉ๐™ž๐™ฃ๐™œ ๐™ฉ๐™๐™š ๐™ฉ๐™ง๐™–๐™ฃ๐™จ๐™˜๐™ช๐™ฉ๐™–๐™ฃ๐™š๐™ค๐™ช๐™จ ๐™ซ๐™–๐™œ๐™ช๐™จ ๐™ฃ๐™š๐™ง๐™ซ๐™š ? Image 2) ๐˜‰๐˜ณ๐˜ช๐˜ฆ๐˜ง ๐˜ด๐˜ถ๐˜ฎ๐˜ฎ๐˜ข๐˜ณ๐˜บ :
This pilot study investigated transcutaneous vagus nerve stimulation (tVNS) for long COVID symptoms in 24 female patients. Following 10 days of at-home tVNS treatment (30 mins twice daily) ...
ncbi.nlm.nih.gov/research/coronโ€ฆ
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May 17 โ€ข 8 tweets โ€ข 3 min read
๐—ง๐—ต๐—ฒ ๐—จ๐—ก๐——๐—˜๐—ฅ๐—˜๐—ฆ๐—ง๐—œ๐— ๐—”๐—ง๐—œ๐—ข๐—ก ๐—ผ๐—ณ ๐—›5๐—ก1 ๐—–๐—”๐—ฆ๐—˜๐—ฆ !

โ–ถ๏ธ EGYPT, Seroprevalence H5N1 in poultry workers : 2.1% (2015), equivalent of 20.000 workers ?
โ–ถ๏ธ WHO, 356 human cases of H5N1 reported in Egypt (9 March 2006 - 30 September 2016)
โ–ถ๏ธ 98% ๐—ก๐—ข๐—ง ๐——๐—˜๐—ง๐—˜๐—–๐—ง๐—˜๐—— ? Image 2) The study in Egypt found that the seroprevalence of avian influenza A(H5N1) antibodies was higher among poultry-exposed individuals. Chronic lung disease was a significant risk factor for infection. A(H9N2) infection was also detected ... Image
May 17 โ€ข 4 tweets โ€ข 2 min read
๐™๐™๐™š ๐™ˆ๐˜ผ๐˜ฟ๐™‰๐™€๐™Ž๐™Ž ! ๐Ÿคฌ
๐™„๐™ฃ 2009, ๐™ž๐™ฃ ๐™– ๐™ง๐™š๐™ซ๐™ž๐™š๐™ฌ, ๐™ฉ๐™๐™š๐™ฎ ๐™–๐™ก๐™ง๐™š๐™–๐™™๐™ฎ ๐™ฅ๐™ง๐™ค๐™ฅ๐™ค๐™จ๐™š๐™™ ๐™ฉ๐™๐™–๐™ฉ ๐™ฅ๐™š๐™ค๐™ฅ๐™ก๐™š ๐™˜๐™ค๐™ฃ๐™จ๐™ช๐™ข๐™š ๐™๐˜ผ๐™’ ๐™ˆ๐™„๐™‡๐™† ๐™˜๐™ค๐™ฃ๐™ฉ๐™–๐™ข๐™ž๐™ฃ๐™–๐™ฉ๐™š๐™™ ๐™—๐™ฎ ๐™ƒ5๐™‰1 ๐Ÿฅธ

sciencedirect.com/science/articlโ€ฆ
Image 2) A brief summary :
In this article they said that in the event of a human-transmitted avian influenza pandemic before effective vaccines or antiviral drugs are available, the outbreak could be significantly slowed through passive immunization with milk and serum ... Image
May 17 โ€ข 7 tweets โ€ข 2 min read
๐˜ผ๐™ข๐™ฎ๐™ก๐™ค๐™ž๐™™ ๐™–๐™œ๐™œ๐™ง๐™š๐™œ๐™–๐™ฉ๐™š๐™จ ๐™›๐™ง๐™ค๐™ข ๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™ค๐™‘-2 ๐™ฅ๐™š๐™ฅ๐™ฉ๐™ž๐™™๐™š๐™จ ๐™ง๐™š๐™–๐™™๐™ž๐™ก๐™ฎ ๐™š๐™ฃ๐™ฉ๐™š๐™ง ๐™ฃ๐™š๐™ช๐™ง๐™ค๐™ฃ๐™–๐™ก ๐™˜๐™š๐™ก๐™ก๐™จ,
๐˜ข๐˜ฏ๐˜ฅ ๐˜ต๐˜ฉ๐˜ช๐˜ด ๐˜ค๐˜ข๐˜ถ๐˜ด๐˜ฆ๐˜ด ๐˜ข ๐˜ณ๐˜ฆ๐˜ฅ๐˜ถ๐˜ค๐˜ต๐˜ช๐˜ฐ๐˜ฏ ๐˜ช๐˜ฏ ๐˜ต๐˜ฉ๐˜ฆ๐˜ช๐˜ณ ๐˜ฎ๐˜ช๐˜ต๐˜ฐ๐˜ค๐˜ฉ๐˜ฐ๐˜ฏ๐˜ฅ๐˜ณ๐˜ช๐˜ข๐˜ญ ๐˜ณ๐˜ฆ๐˜ด๐˜ฑ๐˜ช๐˜ณ๐˜ข๐˜ต๐˜ช๐˜ฐ๐˜ฏ.

biorxiv.org/content/10.110โ€ฆ
Image 2) COVID-19 (caused by SARS-CoV-2 virus) can cause neurological symptoms like memory loss, cognitive issues, and sensory disruption. These symptoms are sometimes referred to as neuro-COVID.
May 17 โ€ข 5 tweets โ€ข 2 min read
๐—”๐—ฑ๐—ท๐˜‚๐˜ƒ๐—ฎ๐—ป๐˜๐—ฒ๐—ฑ ๐˜€๐˜‚๐—ฏ๐˜‚๐—ป๐—ถ๐˜ ๐—ถ๐—ป๐˜๐—ฟ๐—ฎ๐—ป๐—ฎ๐˜€๐—ฎ๐—น ๐—บ๐˜‚๐—ฐ๐—ผ๐˜€๐—ฎ๐—น ๐˜ƒ๐—ฎ๐—ฐ๐—ฐ๐—ถ๐—ป๐—ฒ ๐—ฝ๐—ฟ๐—ฒ๐˜ƒ๐—ฒ๐—ป๐˜๐˜€ ๐—ฆ๐—”๐—ฅ๐—ฆ-๐—–๐—ผ๐—ฉ-2 ๐—ผ๐—ป๐˜„๐—ฎ๐—ฟ๐—ฑ ๐˜๐—ฟ๐—ฎ๐—ป๐˜€๐—บ๐—ถ๐˜€๐˜€๐—ถ๐—ผ๐—ป ๐—ถ๐—ป ๐—ต๐—ฎ๐—บ๐˜€๐˜๐—ฒ๐—ฟ๐˜€ ๐Ÿ‘

biorxiv.org/content/10.110โ€ฆ
Image 2) The study tested the effectiveness of an intranasal adjuvant subunit vaccine compared to an intramuscular mRNA vaccine at preventing SARS-CoV-2 transmission in hamsters.
Hamsters were vaccinated with either 2 doses of mRNA vaccine IM or 1 dose IM followed by an intranasal ..
May 17 โ€ข 7 tweets โ€ข 3 min read
๐—ฉ๐—ฎ๐—ฐ๐—ฐ๐—ถ๐—ป๐—ฒ๐˜€ ๐—ฒ๐˜…๐—ฝ๐—ฟ๐—ฒ๐˜€๐˜€๐—ถ๐—ป๐—ด ๐—ฐ๐—น๐—ฎ๐—ฑ๐—ฒ 2.3.4.4๐—ฏ ๐—›5 ๐—ต๐—ฒ๐—บ๐—ฎ๐—ด๐—ด๐—น๐˜‚๐˜๐—ถ๐—ป๐—ถ๐—ป ๐—ฎ๐—ด๐—ฎ๐—ถ๐—ป๐˜€๐˜ ๐—›5๐—ก1 ๐—ต๐—ถ๐—ด๐—ต๐—น๐˜† ๐—ฝ๐—ฎ๐˜๐—ต๐—ผ๐—ด๐—ฒ๐—ป๐—ถ๐—ฐ ๐—ฎ๐˜ƒ๐—ถ๐—ฎ๐—ป ๐—ถ๐—ป๐—ณ๐—น๐˜‚๐—ฒ๐—ป๐˜‡๐—ฎ ๐Ÿ‘

Thanks to @jlerollblues
sciencedirect.com/science/articlโ€ฆ
Image 2) Researchers developed a recombinant Newcastle disease virus (rK148) vaccine expressing the H5 hemagglutinin (HA) protein of a clade 2.3.4.4b H5N1 highly pathogenic avian influenza virus (HPAIV). This recombinant vaccine was called rK148/22-H5. Image
May 17 โ€ข 4 tweets โ€ข 2 min read
๐—œ๐—ป๐—ฐ๐—ฟ๐—ฒ๐—ฎ๐˜€๐—ฒ๐—ฑ ๐—œ๐—ป๐—ฐ๐—ถ๐—ฑ๐—ฒ๐—ป๐—ฐ๐—ฒ ๐—ผ๐—ณ ๐—œ๐—ป๐˜ƒ๐—ฎ๐˜€๐—ถ๐˜ƒ๐—ฒ ๐—ฃ๐—ป๐—ฒ๐˜‚๐—บ๐—ผ๐—ฐ๐—ผ๐—ฐ๐—ฐ๐—ฎ๐—น ๐——๐—ถ๐˜€๐—ฒ๐—ฎ๐˜€๐—ฒ ๐—ถ๐—ป ๐—›๐—ผ๐—ป๐—ด ๐—ž๐—ผ๐—ป๐—ด ๐—ถ๐—ป 2023

(๐˜ˆ ๐˜ด๐˜ช๐˜ฎ๐˜ช๐˜ญ๐˜ข๐˜ณ ๐˜ฑ๐˜ข๐˜ต๐˜ต๐˜ฆ๐˜ณ๐˜ฏ ๐˜ข๐˜ด ๐˜ช๐˜ฏ ๐˜Œ๐˜ฏ๐˜จ๐˜ญ๐˜ข๐˜ฏ๐˜ฅ โžก๏ธ ๐˜ข๐˜ต ๐˜ต๐˜ฉ๐˜ฆ ๐˜ฆ๐˜ฏ๐˜ฅ ๐˜ฐ๐˜ง ๐˜ต๐˜ฉ๐˜ช๐˜ด ๐˜ต๐˜ฉ๐˜ณ๐˜ฆ๐˜ข๐˜ฅ)
journalofinfection.com/article/S0163-โ€ฆ
Image 2) This study analyzed changes in invasive pneumococcal disease (IPD) in Hong Kong before, during and after COVID-19. IPD cases substantially decreased 2020-2022 when public health measures were implemented but rebounded in 2023 to pre-pandemic levels.
May 17 โ€ข 6 tweets โ€ข 2 min read
๐—–๐—ฟ๐—ผ๐˜€๐˜€-๐˜€๐˜‚๐—ฏ๐˜๐˜†๐—ฝ๐—ฒ ๐—œ๐—บ๐—บ๐˜‚๐—ป๐—ถ๐˜๐˜† ๐—ฎ๐—ด๐—ฎ๐—ถ๐—ป๐˜€๐˜ ๐—”๐˜ƒ๐—ถ๐—ฎ๐—ป ๐—œ๐—ป๐—ณ๐—น๐˜‚๐—ฒ๐—ป๐˜‡๐—ฎ ๐—›5๐—ก1 ๐—ถ๐—ป ๐—ฃ๐—ฒ๐—ฟ๐˜€๐—ผ๐—ป๐˜€ ๐—ฅ๐—ฒ๐—ฐ๐—ฒ๐—ป๐˜๐—น๐˜† ๐—ฉ๐—ฎ๐—ฐ๐—ฐ๐—ถ๐—ป๐—ฎ๐˜๐—ฒ๐—ฑ ๐—ณ๐—ผ๐—ฟ ๐—œ๐—ป๐—ณ๐—น๐˜‚๐—ฒ๐—ป๐˜‡๐—ฎ ๐Ÿ‘

H/t @RolandBakerIII
wwwnc.cdc.gov/eid/article/14โ€ฆ
Image 2) The study evaluated cross-immunity between human and avian influenza (H5N1) strains in healthy people vaccinated for seasonal influenza.
At baseline, some participants had CD4 T cells specific for H5N1, and seasonal vaccination enhanced the frequency of these cells. Image
May 16 โ€ข 8 tweets โ€ข 3 min read
๐—œ๐—บ๐—ฝ๐—ฟ๐—ถ๐—ป๐˜๐—ถ๐—ป๐—ด ๐—ผ๐—ณ ๐˜€๐—ฒ๐—ฟ๐˜‚๐—บ ๐—ป๐—ฒ๐˜‚๐˜๐—ฟ๐—ฎ๐—น๐—ถ๐˜‡๐—ถ๐—ป๐—ด ๐—ฎ๐—ป๐˜๐—ถ๐—ฏ๐—ผ๐—ฑ๐—ถ๐—ฒ๐˜€ ๐—ฏ๐˜† ๐—ช๐˜‚๐—ต๐—ฎ๐—ป-1 ๐—บ๐—ฅ๐—ก๐—” ๐˜ƒ๐—ฎ๐—ฐ๐—ฐ๐—ถ๐—ป๐—ฒ๐˜€

Thanks to @DavidJoffe64
nature.com/articles/s4158โ€ฆ
Image 2) The study evaluated the type-specificity and cross-reactivity of serum antibodies induced by heterologous mRNA SARS-CoV-2 booster vaccines in mice and humans previously vaccinated with mRNA-1273 vaccines. In mice, prior immunity ... Image
May 16 โ€ข 4 tweets โ€ข 1 min read
โ€œ๐™Ž๐™ฅ๐™–๐™ฃ๐™ž๐™จ๐™ ๐™›๐™ก๐™ช,โ€ ๐™š๐™ฃ๐™˜๐™š๐™ฅ๐™๐™–๐™ก๐™ž๐™ฉ๐™ž๐™จ ๐™ก๐™š๐™ฉ๐™๐™–๐™ง๐™œ๐™ž๐™˜๐™–, ๐™–๐™ฃ๐™™ ๐˜พ๐™Š๐™‘๐™„๐˜ฟ-19 : ๐˜—๐˜ณ๐˜ฐ๐˜จ๐˜ณ๐˜ฆ๐˜ด๐˜ด ๐˜ฎ๐˜ข๐˜ฅ๐˜ฆ, ๐˜ญ๐˜ฆ๐˜ด๐˜ด๐˜ฐ๐˜ฏ๐˜ด ๐˜ญ๐˜ฆ๐˜ข๐˜ณ๐˜ฏ๐˜ฆ๐˜ฅ, ๐˜ข๐˜ฏ๐˜ฅ ๐˜ฅ๐˜ช๐˜ณ๐˜ฆ๐˜ค๐˜ต๐˜ช๐˜ฐ๐˜ฏ๐˜ด ๐˜ง๐˜ฐ๐˜ณ ๐˜ง๐˜ถ๐˜ต๐˜ถ๐˜ณ๐˜ฆ ๐˜ณ๐˜ฆ๐˜ด๐˜ฆ๐˜ข๐˜ณ๐˜ค๐˜ฉ

onlinelibrary.wiley.com/doi/10.1111/enโ€ฆ
Image 2) The "Spanish flu" pandemic of 1918 and resulting Encephalitis Lethargica killed millions without identified cause or effective response. COVID-19 showed progress with rapid virus ID and worldwide cooperation enabling swift vaccines ...
May 16 โ€ข 4 tweets โ€ข 2 min read
๐—ฃ๐—ผ๐˜๐—ฒ๐—ป๐˜๐—ถ๐—ฎ๐—น ๐—ฑ๐—ถ๐˜€๐—ฒ๐—ฎ๐˜€๐—ฒ ๐—ฝ๐—ฎ๐˜๐—ต๐—ผ๐—น๐—ผ๐—ด๐—ถ๐—ฒ๐˜€ ๐˜€๐—ต๐—ฎ๐—ฟ๐—ฒ๐—ฑ ๐—ฏ๐—ฒ๐˜๐˜„๐—ฒ๐—ฒ๐—ป ๐— ๐—˜/๐—–๐—™๐—ฆ ๐—ฎ๐—ป๐—ฑ ๐—Ÿ๐—ผ๐—ป๐—ด ๐—–๐—ข๐—ฉ๐—œ๐——

cell.com/trends/moleculโ€ฆ
Image 2) ME/CFS and LC share fatigue, and neuro/immune/autonomic symptoms. Studies find evidence of immune dysfunction, aberrant metabolism, gut microbiome alterations, and CNS involvement in both. Impairment and chronic inflammation are seen, as are reliance on ... Image
May 16 โ€ข 6 tweets โ€ข 2 min read
๐—œ๐—ป๐˜€๐—ถ๐—ด๐—ต๐˜๐˜€ ๐—ถ๐—ป๐˜๐—ผ ๐—ฆ๐—”๐—ฅ๐—ฆ-๐—–๐—ผ๐—ฉ-2 ๐—ฝ๐—ฎ๐˜๐—ต๐—ผ๐—ด๐—ฒ๐—ป๐—ถ๐—ฐ๐—ถ๐˜๐˜† ๐—ฎ๐—ป๐—ฑ ๐—ฐ๐—ฒ๐—น๐—น ๐—ฒ๐—ป๐˜๐—ฟ๐˜† ๐—ฝ๐—ฎ๐˜๐—ต๐˜„๐—ฎ๐˜† ๐˜‚๐˜€๐—ฎ๐—ด๐—ฒ

nature.com/articles/s4146โ€ฆ
Image 2) The researchers performed deep mutational scanning of residues 808-855 of the SARS-CoV-2 spike protein, which spans the S2' cleavage site, fusion peptide and adjacent regions Image