Discover and read the best of Twitter Threads about #wcpg2022
Most recents (16)
First Pat Sullivan electronically introduces the @PGCgenetics #WCPG2022
PGC 1000+ scientists from 50+ countries. Primary funding from NIH, but many others as well. 8 sites, 16 PIs in USA, UK, and Ireland. Coordinating committee including regional representatives. #WCPG2022
I am in the #WCPG2022 IDEA plenary, which discusses the need and approaches to decolonising psychiatric genetics. Panel members are Olivia Matshabane, Paola Giusti-Rodriguez @paolagiustirodriguez, @hailianghuang, and @MeeraPurushott1. Chairs are Lea Davis and John Nurnberger.
[I will tweet as much as I can here, but a discussion is always more challenging to tweet]
First question highlights the impact of colonialism in research. This includes lack of resources and support for ECRs, the need for engaging with and working alongside studied groups throughout the research process, including subsequent data storage, access and usage. #WCPG2022
Next is Omar Shanta who will talk about a GWAS of CNVs in 500k individuals (127k cases, mostly EUR, some AFR). Needed consistent CNV calling across entire cohort. Difficult platforms, which makes things challenging. #WCPG2022
Aims: what is the contribution of rare CNVs, which are those CNVs per disorder, how do rare CNVs compare across disorders? #WCPG2022
Assess multiple metrics of CNV burden, comparing tier 1 (pli > 0.5) and tier 2 (pLI < 0.5). #WCPG2022
I'm back (after a slightly longer lunch) - @juandelahozco is presenting on longitudinal trajectories in the EHR from the Clínica San Juan de Dios, Manizales, Colombia. #WCPG2022
Diagnoses of severe mental illness from ICD10, validated against structured interview and chart review. Some BIP-MDD mismatches (see tweets on @loldeloo talk earlier), but agreement is generally very good, especially for SCZ #WCPG2022
Want to extract presentation information from notes - developed NLP algorithm, required named entity recognition and negation detection. Extracted features align with ICD10 codes #WCPG2022
NeuroGAP seeks to build collaboration across Africa, particularly across early career researchers. Phenotyping working group has members across Kenya, Uganda, Ethiopia and South Africa, as well as from the Broad. Lots of clinicians, valuable for building phenotypes #WCPG2022
8 phenotyping manuscripts accepted, 8 more to come, describing the details of psychiatric phenotyping within and across different African countries #WCPG2022
It's day 3, and @sebatlab is outlining the spectrum of genetic influences that affect autism. Clear that although there are strong rare variant effects, these are not monogenic disorders #WCPG2022
Combining together results from common, rare, and structural variants allows a broader picture of genetic risk. See over-transmission of genetic risk at all levels from parents to affected children #WCPG2022
Can combine common and rare variants together into scores that are more predictive than either score alone. Inverse correlation - individuals with autism with high rare score tend to have lower common score [conditional on having autism - crosses liability threshold] #WCPG2022
*Runs to bipolar* #WCPG2022
In the bipolar session, @MKoromina discussing fine mapping in bipolar GWAS. #WCPG2022
Pipeline: GWAS --> conditional analysis --> fine-mapping (PolyFun + SuSie, + FINEMAP) --> validation (eQTLs, colocalisation) #WCPG2022
I'm running between eating disorders and bipolar this afternoon. Starting in eating disorders, where Nadia Micali is introducing the phenotypes. Eating disorders are very underfunded given how frequent and deadly they are #WCPG2022
Today's focus is anorexia nervosa, binge eating disorder, avoidant restrictive food intake disorder. #WCPG2022
AN is characterised by food restriction, low body weight [although see atypical AN] and fear of weight gain / weight loss behaviours #WCPG2022
Lots of great posters and lunch later, I am now in the methods session for #WCPG2022 (it was a hard decision over depression...) First up is Wouter Peyrot talking about DDx-PRS
@caina89 and @hailianghuang introduce WP. DDX-PRS distinguishes between different psychiatric disorders. Early diagnosis is challenging - non specific symptoms often give way to more specific symptoms ten years on - would be valuable to be able to intervene early #WCPG2022
Genetics is well situated to act as a stable predictor of separating disorders early on. No specific methods to achieve this - enter DDX-PRS. Predicts probability of given disorder from individual genotypes. PRS --> liability scale #WCPG2022
I am in the anxiety session at #WCPG2022 First up is @no_strom presenting on the latest @PGCgenetics GWAS. Introduces the phenotype first - clinically distressing fear/worry
Anxiety is under recognised and under treated in primary care - mostly treated by anxiolytics/anti-depressants and psychotherapies. Disorders tend to start in childhood, and are very comorbid with other psych disorders. Multiple risk factors, 30-40% heritability #WCPG2022
Anxiety GWAS has been slower to get going than other disorders - several previous GWAS, up to 5 GWS hits in different GWAS but replication across cohorts needs to be established #WCPG2022
Day 2 of #WCPG2022 kicks off as @BFranke_lab introduces another awesome speaker: @kristenbrennand who is going to talk about using stem cells to study the genetics of brain disease.
KB starts by nicking @dr_appie's visualisation of the polygenicity of common complex psychiatric disorders #WCPG2022
Animal models have been useful, but are not good for studying non coding variants - lack of conservation, takes time to insert gene effects. Stem cells offer an alternative #WCPG2022
First session of #WCPG2022 proper! @jorsmo welcomes everyone back to meatspace, before introducing @BFranke_lab, one of the program committee chairs, who in turn will welcome everyone to the conference and it's theme of vanishing boundaries across multiple aspects of the field.
BF now introduces Prof Sarah Medland to give the first plenary of #WCPG2022, who will talk about the work of the ENIGMA imaging genetics consortium.
ENIGMA aimed to improve the reproducibility of imaging genetics. Apparent that although imaging costs more, still need the same scale of sample size as other GWAS. The solution - collaboration #WCPG2022
Finally in this session we hear from the @PGCgenetics diversity working groups. First up is the (new!) Consortium for Africa. Numerous African genomics leaders discuss the context and value of the diverse, distinctive human genome in Africa #WCPG2022
Cross-population analyses WG. Working to develop methods. Working with outreach group to highlight (lack of) diversity in psych genomics. Expanding research, grants going in! #WCPG2022
@LAGCPsychGene discuss their work in Latin America. Building large genotype cohorts and beginning GWAS across multiple traits. Methods development too and capacity building. Many collaborators from Latin America. Come and find the @LAGCPsychGene on Wednesday! #WCPG2022
After a brief break for questions, round 2 #wcpg2022
@immaqua describes OCD progress. GWAS ongoing (numerous hits - see symposium on Saturday) and shared with cross disorder efforts. Symptoms analyses yielding publications. Next freeze - diversity and addressing heterogeneity #WCPG2022
Tourettes syndrome WG: new GWAS freeze with GWS hits and replications. Numerous secondary analysis papers from trainees. CNV efforts as well. Oral session on Saturday. Future collaborations across imaging and functional analysis #WCPG2022
It's @PGCgenetics AGM time! Ole Andreassen deputises for Pat Sullivan as the chair #WCPG2022
@PGCgenetics 17 working groups now - meet the work group leaders sessions running across the week #WCPG2022
(Alzheimer's disease update to be added this evening - computer died due to lack of power sockets)
Apologies to the morning folks in the education session (5am landing and an hour or so walking the streets of Florence required a bit of sleep...)
But I'm only chuffing here! Enjoying listening to @KKuchenbaecker explaining the vanishing boundaries of ancestry #WCPG2022
But I'm only chuffing here! Enjoying listening to @KKuchenbaecker explaining the vanishing boundaries of ancestry #WCPG2022
@KKuchenbaecker KK: Defining specific ancestry groups (e.g. through PCA) can be valuable, but comes with risks of abuse by bad actors. Definitions are not always straightforward and easy to get wrong - relatives have an influence on this (and this also --> misestimates of relatives) #WCPG2022
Roadmap for sustainable diverse gneomic studies: pubmed.ncbi.nlm.nih.gov/35145307/. Need to engage groups being studied as active partners and leads of the studies, and have strong focus on capacity building. Highlights efforts in Pakistan #WCPG2022
