Discover and read the best of Twitter Threads about #tyrosine
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Check out our latest paper on @biorxivpreprint!
Phosphorylation of the overlooked #tyrosine 310 regulates the structure, #aggregation, and #microtubule- and #lipid-binding properties of #Tau
biorxiv.org/content/10.110…
Short #thread!
#AcademicTwitter #biochemistry #threadstory
Phosphorylation of the overlooked #tyrosine 310 regulates the structure, #aggregation, and #microtubule- and #lipid-binding properties of #Tau
biorxiv.org/content/10.110…
Short #thread!
#AcademicTwitter #biochemistry #threadstory
Tau misfolding and aggregation are implicated in tauopathies such as #Alzheimers and #PSP. Tau is extensively post-translationally modified and aberrant pattern of PTMs are found in disease. Tyrosine PTMs have received the least attention, especially Y310.
Tau has 5 tyrosines, and Y310 is in the crucial position within the aggregation-prone MT- and lipid-binding repeat domain. It compacts and folds into beta-sheet structure. We asked:
How would addition of bulky negatively charged phosphogroups to tyrosines impact Tau properties?
How would addition of bulky negatively charged phosphogroups to tyrosines impact Tau properties?
My recent DNA #nucleobase etymology thread turned out to be surprisingly popular. So now let's do the amino acids -- #HematologyTweetstory 12. This pretty chart of the #aminoacids is from “BioNinja”: ib.bioninja.com.au/standard-level…
Knowing word origins isn't essential to using terms well, but these histories can be interesting and illuminating. So, while you may not be a bodybuilder💪🏋️♂️🏋️♀️ who eats amino acids to bulk up, you can read #HematologyTweetstory 12 to build up your “body of knowledge". 😉
Let’s start with #Arginine, “the pirate’s favorite AA” (Arrrr!)🤪, first isolated by Ernst Schulze in Zürich (1886) from lupin seeds. His arginine crystals looked silvery; the Greek word árgyros (ἄργυρος)=silver. Argentina, rich in silver ore, gets its name from the same root./2
