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Alright, should we do this? I'm going to attempt my first mini-#tweetatorial on this little capsule right here...
#hydroxyurea is currently the mainstay of disease modifying therapy in #sicklecell disease and with the new landscape of therapeutics, I think we should dive in /1
#hydroxyurea is currently the mainstay of disease modifying therapy in #sicklecell disease and with the new landscape of therapeutics, I think we should dive in /1
It was a century before its first clinical use in cancer that hydroxyurea was created by Drs. Dresler and Stein in Germany. The first approval for clinical use came in 1967 from the @US_FDA for oncological indications. /2
And then in 1984, two key papers in @NEJM and @jclinicalinvest by Letvin et al and Platt et al - FETAL HEMOGLOBIN production! And this of course was the 🔑 that unlocked the potential of HU in SCD. This was the game changer. /3
