Discover and read the best of Twitter Threads about #therapeutic
Most recents (8)
Thrilled to share our latest article in @NaturePortfolio Reviews Immunology exploring the role of platelets in #immune mediated inflammatory diseases such as #SLE. Open access link 🔓 rdcu.be/c4ijW.
A thread
A thread
In autoimmune & inflammatory diseases, platelets get activated in response to circulating autoAbs (directly or through FcGR2A binding), soluble factors such as DAMPs or infectious agents (ie through platelet TLR7). Platelet activation often follows disease activity -> biomarker
Upon activation platelets release pro-inflammatory molecules (ie, IL1b), express glycoproteins that promote the interaction with immune cells (ie P-selectin or CD40L) and release plat-derived extracellular vesicles which enhance the inflam « signal » thorough body & organs.
1) Regarding the recent article shared below, and because this put me in a particular mood today to see #TTI survivors used for industry promotion. Let's explore historically how direct comparison trials fair in #psychotherapy.
2) The first meta-analysis ever found: “More generally, virtually no difference in effectiveness was observed between the class of all behavioral therapies (e.g. #behavior modification) and the nonbehavioral therapies (e.g., Rogerian, #psychodynamic” psycnet.apa.org/record/1978-10…
3) A meta-analysis for #youth #mentaldisorders found: “there was no #evidence of any differences among treatments” tandfonline.com/doi/abs/10.108…
I met an old lady who had #schizophrenia. She was on antipsychotics for more than 50 years. Never remitted. Had delusions of infidelity on her husband. He loved her and brought up his kids. The kids are grown up and married now.
She was also a cancer survivor. Docs repeated the same medicines as there weren't too many problems even though she was not fully well too.
I took a bold decision to start her on #Clozapine, a drug with risks but also better efficacy. Discussed with her and family.
I took a bold decision to start her on #Clozapine, a drug with risks but also better efficacy. Discussed with her and family.
They agreed to monitor her blood counts and the process started. She did well. Her delusion resolved. She smiled at her husband after long time. He was very happy to see her change. I was thrilled to see the joy in their family.
Excited to share our new paper in Nature Chemical Biology @nchembio
AI is poised to transform #therapeutic #science
The Commons is an initiative to access and evaluate #AI capability across therapeutic modalities and stages of discovery 1/4
nature.com/articles/s4158…
AI is poised to transform #therapeutic #science
The Commons is an initiative to access and evaluate #AI capability across therapeutic modalities and stages of discovery 1/4
nature.com/articles/s4158…
@nchembio @KexinHuang5 @TianfanFu @WenhaoGao1 @marinkazitnik @HarvardDBMI @yzhao062 @jure @jimeng @cwcoley @yusufroohani The Commons establishes a foundation for understanding which AI methods are most suitable for drug discovery and why
It provides a robust foundation and modern AI infrastructure to support predictive modeling and data-driven design 2/4
It provides a robust foundation and modern AI infrastructure to support predictive modeling and data-driven design 2/4
@nchembio @KexinHuang5 @TianfanFu @WenhaoGao1 @marinkazitnik @HarvardDBMI @yzhao062 @jure @jimeng @cwcoley @yusufroohani Researchers across disciplines can use the Commons for numerous #drugdiscovery applications 3/4
#1
Stop terming 'therapeutic' experiences, as 'therapy'. Therapy is structured and focused on the client's issues. There is a particular process for therapy which has fixed steps and actions and challenges.
Stop terming 'therapeutic' experiences, as 'therapy'. Therapy is structured and focused on the client's issues. There is a particular process for therapy which has fixed steps and actions and challenges.
#2
Therapy involves guidance, insights and support from a professional. Professionals are trained to help you and education is achieved in order to be informed of various methods to provide that help. Not so that the tag of our profession is given to 'things'.
Therapy involves guidance, insights and support from a professional. Professionals are trained to help you and education is achieved in order to be informed of various methods to provide that help. Not so that the tag of our profession is given to 'things'.
#3
Therapeutic experiences do not necessarily need supervision, guidance, scientific advice or the study of psychology. Drinking tea is 'therapeutic' because one feels relaxed or calm after it. But tea is not your therapist for it to be therapy.
Therapeutic experiences do not necessarily need supervision, guidance, scientific advice or the study of psychology. Drinking tea is 'therapeutic' because one feels relaxed or calm after it. But tea is not your therapist for it to be therapy.
1/16 THREAD🧵3 years ago I proposed that #Psychedelic-Assisted Psychotherapy (PAP) is a #ParadigmShift in psychiatry. The paper has been viewed almost 80k times around the globe and sits at the top 1% views/downloads and top 8% citations of the whole @FrontiersIn journal series.
2/16 Published in the special issue “Psychedelic Drug Research in the 21st Century” it has 82 citations at Google Scholar and was included in one slide by Javier Muñiz, from the FDA’s division of psychiatry, at his ISRP lecture in Oct/2019 frontiersin.org/articles/10.33…
3/16 My perspective on the psychedelic impact on psychiatric research and development was based on Prof. @rose_nikolas useful critique of the current situation in psychiatry as a triple crisis
cambridge.org/core/journals/…
cambridge.org/core/journals/…
1/ Q: How do COVID-19 & the flu compare?
A: They are VERY different. In short – COVID-19 is more deadly, more people are susceptible to it, we have fewer treatments, and even “mild” bouts can leave long-term symptoms.
A: They are VERY different. In short – COVID-19 is more deadly, more people are susceptible to it, we have fewer treatments, and even “mild” bouts can leave long-term symptoms.
2/ To address the elephant in the room: **COVID-19 is MUCH deadlier than the flu.** In fact, since December 2019, #COVID19 has killed more people in the U.S. than influenza has in the past 5 years combined. mck.co/3qh350b
3/ Of course, the burden of COVID-19 is in ADDITION to all the other causes of death around the world, including continuing deaths caused by the flu. bit.ly/2VcB2k2
