Discover and read the best of Twitter Threads about #snATACseq
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In 2019 "Single-cell multimodal omics" was deemed @naturemethods Method of the Year, and since then many new multimodal methods have been published. But are there tradeoffs w/ multimodal omics?
tl;dr yes! An analysis w/ @sinabooeshaghi & Fan Gao in biorxiv.org/content/10.110… 🧵1/
tl;dr yes! An analysis w/ @sinabooeshaghi & Fan Gao in biorxiv.org/content/10.110… 🧵1/
There are a lot of ways to look at this question and we have much to say (long 🧵ahead!). As a starting point let's begin with our Supplementary Figure 4. This is a comparison of (#snRNAseq+#snATACseq) multimodal technology with unimodal technology. Much to explain here: 2/ 
(a) & (b) are showing the mean-variance relationship for data from an assay for measuring RNA and TAC (transposable accessible chromatin) in the same cells. The data is from ncbi.nlm.nih.gov/geo/query/acc.…
Cells from human HEK293T & mouse NIH3T3 were mixed. You're looking at the RNA. 3/
Cells from human HEK293T & mouse NIH3T3 were mixed. You're looking at the RNA. 3/
