Discover and read the best of Twitter Threads about #scTCRSeq
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Our immune system is essential in keeping us healthy.
But the immune system also changes profoundly as we age.
Why is that? Could we prevent it?
Let's see how #singlecell biology can help us better understand #immune #aging
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But the immune system also changes profoundly as we age.
Why is that? Could we prevent it?
Let's see how #singlecell biology can help us better understand #immune #aging
🧵👇
First, some background.
Everybody knows that the immune system is hugely complex.
#singlecell sequencing has (arguably) done more for the immune system than for other health applications.
Via #scRNAseq, we discovered & characterized crazily detailed immune cell phenotypes.
Everybody knows that the immune system is hugely complex.
#singlecell sequencing has (arguably) done more for the immune system than for other health applications.
Via #scRNAseq, we discovered & characterized crazily detailed immune cell phenotypes.
Such detailed phenotypes have been found in both healthy and diseased tissues.
I wrote several threads about this topic and find it to be one of the most foundational & fascinating progresses that have happened in biomedicine in the past 10 years.
I wrote several threads about this topic and find it to be one of the most foundational & fascinating progresses that have happened in biomedicine in the past 10 years.
Today's amazing science dives deep into the 2 strongest #cancer modulators: evolution & immune defense.
First-ever detailed temporal evolutionary trajectories for 600,000 B cell lymphoma immune cells #scRNAseq & #scTCRSeq of 32 patients during immunotherapy with 2 CAR-T drugs 🧵
First-ever detailed temporal evolutionary trajectories for 600,000 B cell lymphoma immune cells #scRNAseq & #scTCRSeq of 32 patients during immunotherapy with 2 CAR-T drugs 🧵
First, what is chimeric antigen receptor (CAR) T cell therapy?
It is an immunotherapy in which the patient's own immune cells are genetically engineered ex-vivo to recognize, attack & kill tumor cells. Then they are infused back into the patient, ready to fight the enemy!🤺 2/13
It is an immunotherapy in which the patient's own immune cells are genetically engineered ex-vivo to recognize, attack & kill tumor cells. Then they are infused back into the patient, ready to fight the enemy!🤺 2/13
Immunotherapies have revolutionized cancer treatment & are among the most promising future approaches.
However: response rates, even if varying across cancers, remain limited, with e.g. 50% response in lymphomas.
Why such therapies fail for the other half remains a mystery 3/13
However: response rates, even if varying across cancers, remain limited, with e.g. 50% response in lymphomas.
Why such therapies fail for the other half remains a mystery 3/13
