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Why do some pts with renal cell carcinoma present w/ polycythemia🩸vs others w/anemia🤔?

1/ Erythropoietin (EPO)➡️glycoprotein that induces differentiation of erythrocytes in the bone marrow to promote RBC production➡️produced in the KIDNEY Image
In RCC➡️EPO is produced ectopically by RCC tumor cells causing abnormalities in RBC production

🧐In fact‼️ ectopic EPO occurs in 66% of RCC pts!

Despite high concentrations of EPO➡️Anemia (⬇️RBC) is common due to poor nutrition🍎, hematuria🩸 or ineffective erythropoiesis🛑
Polycythemia➡️less common in 1-5% of pts, most common in clear cell RCC is due to paraneoplastic production of EPO results in excess RBC and reduction in inhibitory proteins that haunt RBC production!

pubmed.ncbi.nlm.nih.gov/2297568/

#oncopharm
#twitterx #OTILT #renalcellcarinoma #rcc
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