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Humanity has always struggled to fight #viruses , best exemplified by the ongoing #Covid_19 #pandemic ,so I thought of doing a thread on a #virus which frequently troubles #hematology patients
It's called #CMV or #HHV5
It wrecks havoc #posttransplant
#MedTwitter @BloodJournal
It's called #CMV or #HHV5
It wrecks havoc #posttransplant
#MedTwitter @BloodJournal
⚡DNA virus ,1 of the MC infections post SCT
⚡It has the largest genome of any known human virus [230kb /200 genes]
⚡Most humans harbour latent CMV, infection MC aquired in childhood.
⚡Site of latency in humans- Not Known
In murine models - hepatic sinusoidal cells
⚡It has the largest genome of any known human virus [230kb /200 genes]
⚡Most humans harbour latent CMV, infection MC aquired in childhood.
⚡Site of latency in humans- Not Known
In murine models - hepatic sinusoidal cells
⚡The risk of reactivation depends on CMV sero status and is as follows:
D-/R+ > D+/R+ > D+/ R- > D- / R -
⚡The other risk factors are
1️⃣ T cell depletion
2️⃣ HaploSCT
3️⃣ UCB SCT
4️⃣ GVHD requiring Rx
⚡ So why not give prophylaxis to these patients ??
D-/R+ > D+/R+ > D+/ R- > D- / R -
⚡The other risk factors are
1️⃣ T cell depletion
2️⃣ HaploSCT
3️⃣ UCB SCT
4️⃣ GVHD requiring Rx
⚡ So why not give prophylaxis to these patients ??
