Discover and read the best of Twitter Threads about #phenotypes
Most recents (6)
🚨Exciting pre-print from the lab!👉"Pervasive evolution of tissue-specificity of ancestral genes differentially shaped vertebrates and insects". Deep comparative #transcriptomics across #bilateria by @FedeMantica et al @CRGenomica. 👀biorxiv.org/content/10.110…. Summary👇
How has tissue-specific gene expression evolved since the origin of bilaterian animals all the way to extant vertebrates and insects? To address this, we assembled a vast RNA-seq dataset covering 8 tissues and 20 species, generating 95 new RNA-seq samples for 15 species. 1/16 
Importantly, our study was entirely designed around a symmetric #phylogeny for the vertebrate and insect branches, allowing us to identify ancestral features but also parallel, convergent and divergent evolutionary trajectories between and within the two bilaterian lineages. 2/16
Carolyn Calfee Clinical and Biological phenotypes of ARDS
- what do they have in common?
ARDS : subgrouping since the begining
- sepsis vs. non sepsis
- hyper vs. hypoinflamm
- reactive vs uninflamed
#ventilation #ards #phenotypes #LIVES2022
- what do they have in common?
ARDS : subgrouping since the begining
- sepsis vs. non sepsis
- hyper vs. hypoinflamm
- reactive vs uninflamed
#ventilation #ards #phenotypes #LIVES2022
Are clinical phenotypes biologically distinct?
looking at Trauma vs. Non trauma
ICAM-1 , SP-D, vWF, sTNFr-1 are different.
What about in "Direct" vs. "indirect"
or "Diffuse" vs "focal" -- sRAGE comes up again.
pubmed.ncbi.nlm.nih.gov/17944012/
#ventilation #ARDS #LIVES2022
looking at Trauma vs. Non trauma
ICAM-1 , SP-D, vWF, sTNFr-1 are different.
What about in "Direct" vs. "indirect"
or "Diffuse" vs "focal" -- sRAGE comes up again.
pubmed.ncbi.nlm.nih.gov/17944012/
#ventilation #ARDS #LIVES2022
Daily Bookmarks to GAVNet 09/28/2021 greeneracresvaluenetwork.wordpress.com/2021/09/28/dai…
A new era in functional genomics screens
nature.com/articles/s4157…
#HumanGenome #GenomicsResearch #GenomicsTools #GeneCharacterization #phenotypes
nature.com/articles/s4157…
#HumanGenome #GenomicsResearch #GenomicsTools #GeneCharacterization #phenotypes
Age of Invention: The New Space Empires
antonhowes.substack.com/p/age-of-inven…
#colonization #history #SpaceExploration #RawMaterials #extraction #consequences
antonhowes.substack.com/p/age-of-inven…
#colonization #history #SpaceExploration #RawMaterials #extraction #consequences
The Webinar on "Monoclonal gammopathy and its significance for kidneys" is about to begin!
There is still time to test your knowledge by solving the @ISNeducation quiz ➡️ bit.ly/3j7U5cn
There is still time to test your knowledge by solving the @ISNeducation quiz ➡️ bit.ly/3j7U5cn
Starting now!
Webinar: "Monoclonal Gammopathy of Renal Significance - Clinical Perspective" with
@arzuvelix and Serhan Tuglular
#ISNwebinar
Webinar: "Monoclonal Gammopathy of Renal Significance - Clinical Perspective" with
@arzuvelix and Serhan Tuglular
#ISNwebinar
Welcome Dr @arzuvelix and Dr Serhan Tuglular
Webinar: "Monoclonal Gammopathy of Renal Significance -Clinical Perspective" with
#ISNwebinar
Webinar: "Monoclonal Gammopathy of Renal Significance -Clinical Perspective" with
#ISNwebinar
Daily Bookmarks to GAVNet 04/06/2021
greeneracresvaluenetwork.wordpress.com/2021/04/06/dai…
greeneracresvaluenetwork.wordpress.com/2021/04/06/dai…
Rich Man’s Panic (3 of 3)
slopeofhope.com/2021/04/rich-m…
#history #FinancialPanic #StockExchange #interventions #AntiTrustLegislation
slopeofhope.com/2021/04/rich-m…
#history #FinancialPanic #StockExchange #interventions #AntiTrustLegislation
COVID-19 patients can be categorized into three groups
eurekalert.org/pub_releases/2…
#COVID19 #phenotypes #TreatmentStrategy
eurekalert.org/pub_releases/2…
#COVID19 #phenotypes #TreatmentStrategy
The promised #Tweetorial on validation of #COVIDー19 phenotypes that we published @AnnalsATS
But before we start.
Disclosures:
- I'm a splitter and 💕 phenotypes
- If physiology can teach us; I'm all for it!
- But, data and physiology should converge
But before we start.
Disclosures:
- I'm a splitter and 💕 phenotypes
- If physiology can teach us; I'm all for it!
- But, data and physiology should converge
What we know:
- #ARDS can be split into #phenotypes
- But, uncertain therapeutic implications
- #COVID-19 might be split into phenotypes as well
- But, ☝️based on #physiology with little data to back it up.
- #ARDS can be split into #phenotypes
- But, uncertain therapeutic implications
- #COVID-19 might be split into phenotypes as well
- But, ☝️based on #physiology with little data to back it up.
Remember:
- H phenotype = ⬆️elastance (=⬇️compliance) + ⬆️ lung weight + ⬆️shunt + ⬆️recruitability. What we consider ARDS.
- L phenotype is opposite - not resembling most ARDS cases.. Would not benefit ⬆️PEEP, ⬆️TV?
Lung morphology is explained here:
- H phenotype = ⬆️elastance (=⬇️compliance) + ⬆️ lung weight + ⬆️shunt + ⬆️recruitability. What we consider ARDS.
- L phenotype is opposite - not resembling most ARDS cases.. Would not benefit ⬆️PEEP, ⬆️TV?
Lung morphology is explained here:
