Discover and read the best of Twitter Threads about #pegvirus
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Yet another team ties #neuroinflammation to persistent brain infection 👉 Here, RNA seq + western blot + antibody testing identified pegvirus inside the #brain cells of two patients who died from encephalitis (and not controls): folio.ca/u-of-a-scienti… 
Important that pegvirus acted as an intracelluar #pathogen (viral antigens were found inside glial cells + lymphocytes + astrocytes)☝️..w/ their presence in lymphocytes suggesting the “cells might serve as a Trojan horse for #viral infection of the brain parenchymal cells.”
Also important is that detection of #pegvirus-antigen in the pre-transplantation bone marrow biopsy of one subject 👉 “indicated that this patient was infected at least 15 years before #neurological presentation, suggesting a period of viral latency.”
