Discover and read the best of Twitter Threads about #myopathy
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@BrighamMedRes @BostonChiefs Causes of elevated CK level @AnnKumfer #Rhabdo #Rhabdomyolysis #Tipsfornewdocs 
Since #COVID hit, we're hearing a lot about critical illness #myopathy (CIM). Follow this tweetorial that will cover the basic aspect of CIM. Photos below are from a patient with COVID-related CIM.
CIM is a syndrome rather than a distinct entity. It refers to patients who develop a myopathy while being critically ill. The classic characteristic histologic finding is that of "myosinolysis" or loss of myosin.
As the muscle fiber type is determined by the myosin heavy chains, loss of myosin results in "unclassifiable" fibers. Biopsy photos show ATPase reaction at pH9.4 (left), type 2 in dark brown (type 1 light brown), and pH 4.3 (right) with type 1 in dark brown (type 2 pink).
