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Very excited to present my first article, "Mechanistic modeling of metastatic relapse in early-stage breast cancer (eBC) to investigate the biological impact of prognostic biomarkers" !
(supervision @SBenzekry)
#cancer #mathonco #mechanisticModeling #nlme
doi.org/10.1016/j.cmpb…
(supervision @SBenzekry)
#cancer #mathonco #mechanisticModeling #nlme
doi.org/10.1016/j.cmpb…
Our model is (voluntarily) simple and describes the metastatic process through 2 mathematical parameters: alpha (growth) and mu (dissemination), to be confronted to distant metastasis-free survival (DMFS) data 
We studied 3 clinical datasets, 2 datasets with routine data (Bergonie, n = 591 and AP-HM, n = 167) and the latter from public databases (IPC, n= 676).
