Discover and read the best of Twitter Threads about #mdssm
Most recents (3)
On the inpatient leukemia service for the next 2 weeks, time to start sharing daily articles!
Day 1: our experience with inotuzumab re-treatment in Ph-negative B-ALL @jalbanmd @AyaOncologist #leusm
pubmed.ncbi.nlm.nih.gov/36240471/
Day 1: our experience with inotuzumab re-treatment in Ph-negative B-ALL @jalbanmd @AyaOncologist #leusm
pubmed.ncbi.nlm.nih.gov/36240471/
@jalbanmd @AyaOncologist Day 2: efficacy of FLT3 and IDH1/2 inhibitors in AML prev tx w/ venetoclax #leusm
-ORR of 18% for entire cohort; ORR of 30% for pt treated w/ gilteritinib
- median OS of 4.2 months
sciencedirect.com/science/articl…
-ORR of 18% for entire cohort; ORR of 30% for pt treated w/ gilteritinib
- median OS of 4.2 months
sciencedirect.com/science/articl…
@jalbanmd @AyaOncologist Day 3: hyperleukocytosis in AML
- 779 pt with WBC > 50K at presentation, leukostasis in 27% & leukapheresis used in 15%
- mOS was 12.6 months for entire cohort
- leukapheresis did not appear to impact 30d mortality
pubmed.ncbi.nlm.nih.gov/32132655/
- 779 pt with WBC > 50K at presentation, leukostasis in 27% & leukapheresis used in 15%
- mOS was 12.6 months for entire cohort
- leukapheresis did not appear to impact 30d mortality
pubmed.ncbi.nlm.nih.gov/32132655/
Long awaited study (at least for me) on maintenance after hematopoietic cell transplant (BMT) for patients with TP53 acute myeloid leukemia (AML) or myeloid dysplastic syndrome (MDS) @JCO_ASCO ascopubs.org/doi/full/10.12…
Congrats to all !
It's a tricky one. A🧵#leusm #bmtsm #mdssm
Congrats to all !
It's a tricky one. A🧵#leusm #bmtsm #mdssm
Prologue: TP53 mutation is present in ~15-20% and is associated with a poor prognosis in AML and MDS, even in patients who undergo BMT. acsjournals.onlinelibrary.wiley.com/doi/10.1002/cn…
Eprenetapopt is a prodrug, small-molecule p53 reactivator, converted into an active moiety, 2-methylene quinuclidine-3-one, stabilizing p53 and targets cellular redox balance to increase oxidative stress & induce cell death.
The story of 1 day in the life of a #hematopathologist… I’m too exhausted to make a fancy educational thread but here are some amazing 🔬 pics for your viewing pleasure. I diagnosed all cases in one day 🤯 only at @MDAndersonNews Happy almost weekend people 🥂 #hemepath 🧵 1/n
Myeloproliferative neoplasm w/ concurrent BCR::ABL1 and JAK2 V617F ..the megekaryocyte morphology is clue to something beyond CML #mpnsm #PathOutPic 2/
BPDCN with perfect so-called “hand mirror” (red) and “pearl necklace” (black) morphology #BPDCN #PathOutPic 3/
