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Molecular mechanisms contributing to the pathogenesis of severe COVID-19 in pregnant women. mdpi.com/1999-4915/13/1…
mdpi.com/1282034 #mdpiviruses vía @VirusesMDPI @MDPIOpenAccess @INPer_mx
mdpi.com/1282034 #mdpiviruses vía @VirusesMDPI @MDPIOpenAccess @INPer_mx
Spike protein of SARS-CoV-2 virus binds to trophoblastic cells expressing ACE-2, (1) blocking the conversion of ANG-II into ANG 1-7.
(2) Accumulation of ANG-II on the cell surface enhances its binding to the AT-1 receptor (AT-1R), promoting downstream signaling, followed by rapid endocytosis of the ANG-II/AT-1R complex.
Neuropathological changes with pronounced neuroinflammation have been described in individuals after lethal #COVID19, as well as in the CSF of hospitalized patients with neurological complications. mdpi.com/1579664 #mdpiviruses via @VirusesMDPI
To assess changes can occur POST #SARSCoV2 infection, leading to mild-to-moderate disease, we investigated the brains of four rhesus and four cynomolgus macaques after pulmonary disease and without overt clinical symptoms.
Postmortem - Infiltration of T-cells and activated microglia in the parenchyma of all infected animals, even in the absence of viral antigen or RNA. Moreover, intracellular α-synuclein aggregates were found in the brains of both macaque species.
