Discover and read the best of Twitter Threads about #mastcells
Most recents (4)
Stabilization of #mastcells inhibits bacteria induced #neuroinflammation #MCAS pubmed.ncbi.nlm.nih.gov/31130850/
1/2 Microglia are the immune system of the brain. Researchers set out to discover if injecting the outer membrane of bacteria called LPS into mice triggered mast cells to activate microglia, contributing to neuroinflammation.
2/2 The determined bacterial LPS caused #mastcellactivation and cognitive impairment. The researchers also found the use of #cromolyn effectively stabilized mast cells and neuroinflammation and memory dysfunction.
2 yrs ago, to raise awareness for the #MillionsMissing due to #MECFS, I started a 🧵 on how tragic chronic illness has consumed my life
But I was too sick to finish, & shortly after uninstalled Twitter. Trapped by illness, unable to advocate.
2 surgeries later... 🧵, 🎬 2
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But I was too sick to finish, & shortly after uninstalled Twitter. Trapped by illness, unable to advocate.
2 surgeries later... 🧵, 🎬 2
1/
2017: I was Prof of #Epidemiology @PublicHealthUGA, researching #HIVprevention and #vaccine prep for emerging epidemics. I directed an epi training program @ICI3D. I loved my work & my amazing colleagues!
I was healthy & active 🚴🏄♂️ 🥁
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I was healthy & active 🚴🏄♂️ 🥁
2/
Then, I bought a 🏡 and had it renovated. Jan 2018 I moved to the newly built master bedroom addition, I became sick.
⏩ 2 years to 2020. Water burst thru walls on 2 sides of my bed. Revealing walls, subfloor, crawl space filled with mold due to construction defects
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⏩ 2 years to 2020. Water burst thru walls on 2 sides of my bed. Revealing walls, subfloor, crawl space filled with mold due to construction defects
3/
Very happy (and relieved) that our work on a beneficial function of the #AllergyModule of the #ImmuneSystem (#IgE antibodies and #MastCells) in host defense against #bacteria is out: cell.com/immunity/fullt…
Please check out the paper or the thread below if you want to know more
Please check out the paper or the thread below if you want to know more
2/11 First things first: Many thanks to the amazing people and friends involved in this study over the last 6 years, especially my mentors Steve Galli @stanford and @sylviaknapplab as well as all co-authors (on twitter: @lauren_popov, @S_Zahalka, @maryemradhouani, @immceptionl)..
3/11 ...and host institutions @cemm_news, @meduni_wien and @stanfordmed; special thanks to @bobby_network for the superfancy 3D artwork! 
I have a ton of brain fog today, so bear with me, but I saw a lot of convos happening about #MCAS last night and I wanted to chime in with some info I've learned in the last decade since my #mastocytosis diagnosis.
For those unfamiliar, everyone's bodies have #MastCells. They're part of your immune system and they're responsible for a few things, but primarily they store ~200+ chemicals (called mediators) and release them when fighting off infections, allergens, etc.
These mediators do lots of different things, and some of them are responsible for telling other cells in your body what to do. When Mast cells release mediators it can set off big chain reactions that can impact most, if not all, the systems in your body.
