Discover and read the best of Twitter Threads about #massspec
Most recents (3)
Very happy to present our #proteomics analysis of #lungcancer published today @NatureCancer!🙂
Here’s a walk-through: #MassSpec analysis covering almost 14k proteins in 141 NSCLC tumors revealed 6 proteome subtypes with distinct biology. 1/6
rdcu.be/cBOtU
Here’s a walk-through: #MassSpec analysis covering almost 14k proteins in 141 NSCLC tumors revealed 6 proteome subtypes with distinct biology. 1/6
rdcu.be/cBOtU
#NSCLC proteome subtypes are driven by histology, growth pattern, immune cell infiltration, driver mutations, oncogenic pathways, and cell types, suggesting potential clinical value for treatment stratification and #PrecisionMedicine. 2/6
Unexpectedly, #proteogenomics analysis revealed that high neoantigen burden was linked to global hypomethylation, and that complex neoantigens mapping to genomic regions normally not active in lung were produced in immune-cold subtypes. 3/6
Immensely proud of bring of bringing some important aspects of #precision #proteomics to @NatureRevGenet with @ksuhre @markmccarthyoxf covering #gwas #pqtls and more nature.com/articles/s4157… @scilifelab @KTHresearch @ProteinAtlas
We provide insights into procedures, challenges, considerations and opportunities when combing #genetics and #proteomics for more informed, large scale studies of the circulating #proteome . #biobanks #olink #somalogic #massspec #affinityproteomics #epitopes #causality
Am very grateful to @ksuhre and @markmccarthyoxf for joining in on this journey and making this a wonderful experience over three continents, timezones, project and travel schedules!
We’ve just had a paper published and I would like to tell you a story about people in science being nice to each other – a thread cell.com/cell/fulltext/…
This is a large, collaborative effort – 54 authors across multiple institutions, led @MountSinaiNYC and @CVRinfo. But the science in the story is quite simple (and you can read it in the paper), so I’ll explain it quickly before telling a different story (which you cannot)
Briefly, here’s the science of it. THE BACKGROUND: (i) Viruses need to make mRNA that host ribosomes can translate into proteins
