Discover and read the best of Twitter Threads about #longSARS

Most recents (24)

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Dr Elisa Perego
@elisaperego78
A kind reminder many survivors of the first SARS were ill for years and at least some (where analysis is done or first-hand testimonials are available) never recovered. I don't know how people can think mass infection with SARS-CoV-2 is ok, including for children

#longSARS
About the latest research on the long-term damage from SARS (#longSARS) this from just one month ago

thelancet.com/journals/eclin…
But it was already known before the current pandemic: SARS left many people who survived the acute phase of the disease with prolonged ill health, prolonged disease. A thread of mine on the topic from 2021, where you can find more sources

Read 4 tweets
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Dr Elisa Perego
@elisaperego78
I am retweeting this thread of mine from last year on the so-called "medium covid". We're seeing this concept going around again, trying to minimize #LongCovid. And create confusion. You can be ill from SARS-CoV-2 infection for months, years, a lifetime. Be careful out there
From my last year's thread, actually, more research data have come out, which reinforce our concerns for the prolonged effects of SARS-CoV-2 infection on human health. For example, growing evidence about the association with autoimmune diseases

thelancet.com/journals/eclin…
There is increasing evidence about the effects of SARS-CoV-2 infection on our DNA and gene expression, with potential deleterious, nefarious implications for #LongCovid

nature.com/articles/s4156…

nature.com/articles/s4155…
Read 8 tweets
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Paul Maidowski
@_ppmv
1. How does SARS cause immunosenescence?

Its unique flawed reproduction process in the cytoplasm creates free floating misfolded protein (prion) debris. It causes mitochondrial damage in #LongCOVID #LongSARS patients or immune-mediated damage (complement cascade or feed-forward)
2. AJ thinks T cells are both killed when terminally differentiated via FAS; and naïve T cells are aged through bystander activation and via the feed-forward controller, creating a negative feedback loop to soaking up pro-inflammatory cytokines to prevent severe illness or death.
3. There are other mechanisms; read about complement activation for instance. 结果, SARS-CoV-2 appears perfect at serially challenging and insidiously aging the immune system.

Other viruses that cause similar immune aging teach us that a cure must address these exact mechanisms.
Read 5 tweets
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Paul Maidowski
@_ppmv
1. WHO may end the COVID-19 PHEIC in May. Then what?

(1) We are through the looking-glass. @RealCheckMarker introduces what's next.

(2) Priority: Stop SARS-CoV transmission because re-infection policy (RIP) is unsustainable.

(3) Read up on mitochondria.
mdpi.com/2218-273X/13/1…
@RealCheckMarker (2) What makes HCoV and #LongSARS, #LongCOVID or Post-COVID-19 Condition (#PCC) unique?

The SARS, MERS, OC43 replication process is so sloppy, "CoV shouldn't exist". It creates misfolded proteins (~prions?) that cause mitochondrial and multisystem damage.
@RealCheckMarker 2. Good intro cals.ncsu.edu/applied-ecolog…

Reframed* here in graphical language:

* Always read all threads linked. If you only read individual tweets, you won't learn; this is epi twitter university, not facultative, as no one else is sharing this info yet ;)
Read 6 tweets
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Dr Elisa Perego
@elisaperego78
There are many infectious diseases where the early phase is "mild" or asymptomatic. But the prolonged pathology is not, and can be severe in the long-term. Examples are HIV/AIDS or EBV/multiple sclerosis. Don't necessarily trust SARS-CoV-2 if the early infection is uneventful 🧵
Pathogens have, obviously, their own specific features and mechanisms of actions. SARS-CoV-2 is not EBV/ Epstein Barr virus or HIV. What I'm saying here, is that the immediate clinical manifestations of an infection aren't necessarily indicative of overall severity
Since early 2020, we have known that SARS-CoV-2 can manifest with pauci-symptomatic/asymptomatic early pathology, which can kill or disable with time. Covid can manifest with an early mild flu-like illness (prodromal phase) which progresses to death

thelancet.com/article/S0140-…
Read 13 tweets
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Paul Maidowski
@_ppmv
1. mpox: human monkeypox virus (hMPXV) doesn't enter the nucleus. Genetic recombination with SARS-CoV-2 in the cytoplasm is possible in co-infected patients, eg people living with uncontrolled HIV-1 (PLH). It's the real threat of Covid Denial or Let 'er RIP policy.

#SIDU 230206
2. Covid can have the same effect, causing lymphopenia in perhaps 1 in 3 patients (severe #LongCOVID (#LongSARS) can be compared to HIV/AIDS).

Influenza, SARS, HIV, mpox Protein E8L follow shared evolutionary dynamics for electrostatic surface potential & co-receptor switching.
3. Practical implication for clinicians: Test patients presenting with mpox symptoms for all three diseases.

Practical implications for all else: read science.
sciencedirect.com/science/articl…
mdpi.com/1999-4915/15/2…
mdpi.com/1420-3049/27/1…
mdpi.com/1999-4915/14/1…
Read 28 tweets
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Dr Elisa Perego
@elisaperego78
The first sequences of SARS-CoV-2 from 3 years ago showed the novel coronavirus was similar to SARS CoV, the virus causing the severe SARS. This is why the Covid virus is called SARS-CoV-2. Many SARS survivors were ill for years or never recovered. Why then "living with" covid?
On the long-term health effects of the first SARS, see preliminarly a thread I curated in 2021 (#longSARS). We have been aware of the dangers of SARS CoV since early in the pandemic. This has been a huge red flag for SARS-CoV-2

The similarities between the novel coronavirus and SARS were already picked up in January 2020 in top scientific journals like @TheLancet. Concerns about the risk for a pandemic like the devastating "Spanish" flu pandemic of 1918 were also raised

thelancet.com/journals/lance…
Read 6 tweets
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Dr Elisa Perego
@elisaperego78
We were saying there was going to be a tidal wave of #LongCovid almost three years ago. It was particularly evident if you were in an early covid hotspot, with healthcare and social systems collapsing under unleashed SARS-CoV-2 spread. It's not a new story.
A bit tired of "experts" in the news and other outlets presenting #LongCovid as a "potential future disaster". Long Covid was openly recognized by the WHO in August 2020 following intense advocacy from people suffering from the disease. We have known for almost three years
Of course, we have extensive evidence of other viruses causing long-term health problems (e.g. HIV, EBV, Ebola virus, dengue, poliovirus, etc.). I'm not even going into the evidence about the first SARS and sequelae #longSARS
This pandemic has been an ongoing catastrophe
Read 5 tweets
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Dr Elisa Perego
@elisaperego78
Looking forward to talk about #LongCovid at the PANSOC
—Centre for Research on Pandemics & Society— webinar series @CASOslo on 16 March 2023
I will speak about “Long Covid: history, research, future challenges.” Thanks @jesdimka for the kind invitation

uni.oslomet.no/pansoc/
A lot of other interesting talks in the spring PANSOC webinars for those interested in present and past epidemics/ pandemics, epidemiology, and human health across different societies and periods @jesdimka

In my talk, I will address the rise of #LongCovid as an international patient-led research and advocacy movement in 2020— the latest research on the disease— and the role of Long Covid in a reassessment of viral-onset diseases and sequelae like #longSARS and (pandemic) #longflu
Read 6 tweets
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Dr Elisa Perego
@elisaperego78
I fail to understand how a disease —covid— could kill an estimated 15 million people in two years despite the prodigies of modern medicine and unprecedented safety measures — and leave almost all survivors basically unscathed.
Make no mistake. Morbidity from covid is huge.
Several lines of evidence — which are irrefutable especially when taken together — point to severe levels of prolonged disease, increased mortality risk, chronic illness, and disability following SARS-CoV-2 infection
First, the lived experience of survivors, who have been raising the alarm since the first wave and in subsequent waves. Patients identified, defined, and named Long Covid. Further research have fully confirmed those reports. We did say Long Covid was a catastrophe in the making
Read 17 tweets
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Dr Elisa Perego
@elisaperego78
This is @TheLancet report on the pandemic failures. #LongCovid a disease that has disabled, made ill for prolonged periods of time, and even killed hundreds of millions of people is only mentioned in a small piece at page 57. Which doesn't address the gravity of the disease
#LongCovid is not exactly "emerging" as we've known about it since 2020. It was known before the pandemic a great percentage of SARS survivors never recovered or were ill for years #longSARS. Failure to mitigate SARS-CoV-2 spread and to support survivors is a huge failure
The short report has some good points. But is also highlights "post traumatic stress disorder", "mental health" and an incomplete list of symptoms more than the devastating cardiovascular, metabolic, multi-organ etc. sequelae that we know are a key facet of #LongCovid since 2020
Read 8 tweets
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Dr Elisa Perego
@elisaperego78
It was known SARS was leading to chronic disease before this pandemic started. Yet, COVID, from a not dissimilar virus, SARS-CoV-2, has been presented across the pandemic as "just a bad flu" or a "cold"
We need accountability
#LongCovid #longSARS
Obviously, we also knew other viruses were leading to long-term sequelae. This is the case of influenza, too, in some cases. But SARS-CoV-2 as a pathogen was quite similar to SARS CoV. It's called SARS-CoV-2 for a reason. Yet, SARS morbidity was not addressed in policymaking
The first news out of China were speaking of a "potential SARS outbreak". Already on 31 December 2019. Not a "cold outbreak"

crisis24.garda.com/alerts/2019/12…
Read 17 tweets
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Dr Elisa Perego
@elisaperego78
Honoured to support children living with #LongCovid and their families in asking for better research, treatment, and support from the UK government. Long Covid is a disaster in the making, which risk to affect young people for years and decades to come

@LongCovidKids
It is imperative we stop transmission of SARS-CoV-2 as much as possible. This is especially in crowded indoor environments, where children are at high risk of infection. It is key to provide the best possible treatment and support for children already affected by #LongCovidKids
For the UK itself, we know from the @ONS survey and data provided by support groups ~ charities like @LongCovidKids that a non-insignificant number of children and young people infected with SARS-CoV-2 go on to develop prolonged symptoms, sequelae and health problems #LongCovid
Read 9 tweets
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Dr Elisa Perego
@elisaperego78
I've just seen another verified Twitter account saying we can't keep viruses "at bay forever".
Yet, yes! key research and public health have literally worked towards keeping dangerous pathogens "at bay forever".
Let's see some examples based on the scientific evidence!

🧵
Smallpox

"thanks to .. vaccination, the last natural outbreak of smallpox in the US occurred in 1949. In 1980, the World Health Assembly declared smallpox eradicated (eliminated), and no cases of naturally occurring smallpox have happened since"

CDC

cdc.gov/smallpox/index….
Eradication of the poliovirus, which causes the disease poliomyelitis, has been almost achieved. There have been delays in some areas, also in relation to the covid pandemic. The WHO and other organisations remain committed to eradication

emro.who.int/polio-eradicat…
Read 32 tweets
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Dr Elisa Perego
@elisaperego78
Yes. The covid pandemic has created a mass disabling event. This includes the huge omicron wave: the "wall of immunity" some "experts" were talking about wasn't much real
Did we know about the possibility of a mass disabling event 2 years ago?
Yes!

washingtonpost.com/health/2022/06…
The first SARS, a disease which shares many similarities with covid, left many survivors struggling for years. Some never recovered. Some were alerting us in early 2020 already.
A thread I curated on #longSARS

Viruses and other pathogens are linked to many prolonged illnesses and sequelae, from ME to post Ebola syndrome. Sometimes, the damage triggered or driven by infection will emerge decades later.
A thread I curated with viral onset diseases

Read 9 tweets
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Dr Elisa Perego
@elisaperego78
Not sure how it's possible public health officials "initially believed only a small minority of people would suffer from Long Covid". I wrote some of the first papers ever on #LongCovid myself. Co-authors and I wrote the costs were going to be "unfathomable" = huge | in 2020

🧵
"Research indicating sequelae even in asymptomatic/pauci-symptomatic cases, suggests screening and treatment may be needed for millions" | a note: we wrote this in summer 2020 | we're now at hundreds of millions, if not billions, of infected people at risk!
An early report by @patientled found a significant percentage of people in their sample had
prolonged symptoms for several weeks | a note: we're again in 2020, so the survey was based on an early timeframe | but prolonged disease in many was evident!

patientresearchcovid19.com/research/repor…
Read 11 tweets
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Dr Elisa Perego
@elisaperego78
Covid can be a prolonged disease, with multiple symptoms and sequelae across time. It can kill down the disease course
It's what first wavers told you: #LongCovid. The ramifications of the early "mild" viral infection can be enormous, even with subclinical ("silent") pathology 🧵
We've discussed this many times. The early, "acute" infection in HIV is usually mild ~ asymptomatic. The end point of the disease, with no treatment, is AIDS. This is not to say SARS-CoV-2 infection is the same as HIV infection. They are different viruses

en.m.wikipedia.org/wiki/HIV
But the end point of HIV infection, SARS-CoV-2 infection, SARS CoV infection, mononucleosis from EBV infection, and many others, is not necessarily the early symptoms. This is especially with no treatment! The pathological process triggered by a pathogen is often very complex.
Read 14 tweets
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Dr Elisa Perego
@elisaperego78
Good to see more talking about Long Covid. But this not entirely correct. We know *a lot* about #LongCovid. There are thousands of papers. We know there is prolonged damage in basically all organs and body systems, with many severe effects involving the cardiovascular system

🧵
In a research letter from late summer 2020, my co-authors and I wrote that damage inflicted by #LongCovid on individuals, society, and healthcare was going to be so high to be "unphantomable".
We were right.
Society as a whole still need to grasp with the effects of SARS-CoV-2
We need policy makers and medical professionals to be crystal clear in their messaging on #LongCovid. The prolonged effects of SARS-CoV-2 infection ~ Covid are multiple, with an increased risk of death, severe cardiovascular events, like pulmonary embolism or heart failure
Read 17 tweets
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Dr Elisa Perego
@elisaperego78
Yes, it key to underline this every time. Medical professionals and policy makers were appropriately informed about the risk of #LongCovid in early 2020. By May 2020, Long Covid was an established phenomenon. By August 2020, it was formally acknowledged by @WHO.
It was already known at the beginning of the pandemic many SARS survivors were ill for years, or had never recovered. I collected information around this under #longSARS. SARS-CoV-2, of course, is called as such for its similarities with SARS-COV.
Therefore, the pandemic has been mismanaged since the beginning. Morbidity from a SARS virus was not accounted for. MERS, the other severe coronavirus to have spilled into humans, similarly had high morbidity. Covid is not a "bad flu" or a "cold".

#longMERS
Read 4 tweets
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Dr Elisa Perego
@elisaperego78
Article @guardian by Twitter blue check starts by trying to defend the "herd immunity" strategy in 2020.
No.
We had known since day 1 covid was SARS-like. Since January 2020 it was sending the "young" and "healthy" to the hospital
Herd immunity was always a deranged strategy

🧵
I offer here the basic scientific evidence that covid was never a "flu", a "cold", or a disease you would infect your child or any person with. The science was out in early 2020. Any action taken afterwards by policy makers must be evaluated in view of these data.
Out on 31 December 2019
"China health officials investigating potential SARS outbreak". SARS, not influenza, or the common cold. There are many such articles on the web if you want to look for it yourself.

crisis24.garda.com/alerts/2019/12…
Read 7 tweets
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Dr Elisa Perego
@elisaperego78
Yes. We've been walking blindfolded into uncharted territory. Not only the huge range of action of SARS-CoV-2 via ACE2. Not only the transmission rate. But also the great capability of the virus to evolve fast, relentlessly. It was already clearly evolving in China and Lombardy
The other two severe coronaviruses which spilled into humans, SARS CoV and MERS CoV, never became pandemic. We didn't learn enough from them. What we clearly knew, such as about high morbidity levels, wasn't considered appropriately at the beginning of the pandemic.

#longSARS
Covid doesn't have a huge mortality rate, especially with vaccination. It does have, though, a monstrous morbidity rate. This is evident from current research, patient testimony, and the virus' nature itself. You can't pretend a virus which uses the ACE2 receptors |
Read 4 tweets
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Dr Elisa Perego
@elisaperego78
If we had followed a zero covid strategy like New Zealand and China, this pandemic could have been under control in 2020.
People have been lied to ("it's just a cold", it's "endemic") and pushed into mass infection, disability, and massive social disruption
We need accountability
And, yes, we knew it was a SARS disease on 31 December 2019, we suspected/knew it was airborne in early 2020, we knew it could cause a pandemic in January 2020, we knew it could affect the "young and healthy" in January 2020, we knew about post viral illness before the pandemic
We knew about SARS sequelae #longSARS before the pandemic, we knew people weren't recovering in "2 weeks" in March 2020, we knew covid wasn't a respiratory disease only in winter to spring 2020, and #LongCovid was an established phenomenon by May 2020
Read 15 tweets
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Dr Elisa Perego
@elisaperego78
Congratulations to @LongCovidKids
and allies for being at Downing Street today and raise awareness of #LongCovid in children and young people 🔥
Proud and committed as usual to support recognition of, and research, into #LongCovidKids

express.co.uk/news/science/1…
There are an estimated ~119.000 children and young people to have experienced #LongCovid in the UK alone. Around 21.000 have been ill for over 1 year. The real numbers could be even higher: some children might be living with subclinical ("silent") pathology or undiagnosed disease
We don't even know about the longest-term effects of SARS-CoV-2 infection in the years/decades to come. Data from other viral infections are sobering: we know viruses are associated, or suspected to be associated, with a wide range of conditions emerging much later from infection
Read 10 tweets
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Dr Elisa Perego
@elisaperego78
Exactly. Those who are all for "let's go back to normal" are literally telling those who are more at "risk" they don't care if those "vulnerable" people die
BUT
Here is the lie within the lie by many policy makers. Covid is Russian roulette. The "other" could be you
#LongCovid
Of course, vaccination has made it more difficult to die or suffer severe disease. This is good! But you never know what happens if you get infected. You don't know if it's you to get #LongCovid. We have already reports about Long Covid happening even in the vaccinated.
It was the same in early 2020: do you remember?
"Only the old and sick will die" "covid is a flu" many policy makers said. This was not true. Many people hospitalized in Wuhan --as per the publications in January 2020 --weren't old. Covid was already proven to be a SARS disease
Read 5 tweets

Related hashtags

#longSARS #LongCovidKids #LongCovid #PCC #LeonardiEffect #SARS #MECFS #LongSARS #SIDU #longhaulers #LongCOVID #covidpersistente #apresJ20 #longflu #longMERS

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