Discover and read the best of Twitter Threads about #lipedema
Most recents (2)
In a Letter to the Editor published yesterday by the Journal of Translational Medicine, I describe my hypotheses about a key source of pain and inflammation in #MECFS that may also play a role in post-exertional malaise (#PEM). 1/ …nslational-medicine.biomedcentral.com/articles/10.11…
My hypotheses are grounded in experience as a caretaker for my daughter with hypermobility Ehlers-Danlos Syndrome (#EDS), #MECFS, #POTS, #Chiari malformation, and #craniocervical instability and my reading of the #MECFS and #lipedema literatures. May also apply to #LongCovid 2/
In a nutshell, my hypothesis is that vascular damage and/or endothelial dysfunction causes interstitial fluid to leak from blood vessels of people with #MECFS, leading to formation of adipose tissue that becomes fibrotic, causing inflammation, hypoxia & widespread pain. 3/
This thread outlines my hypotheses on how leakages from microangiographic blood vessels contribute to pain, inflammation and post-exertional malaise in people w/ #MECFS and #LongCOVID. This mechanism is most pronounced in people with a connective tissue disorder. 1/
The core of my hypotheses is that COVID-19 or other viruses cause damage to endothelial cells in blood vessels, which increase their permeability, leading to the release of interstitial fluid which floods affected tissue, creating hypoxic conditions that trigger inflammation. 2/
The increased interstitial fluid eventually forms subcutaneous adipose tissue, which becomes fibrotic and painful to touch, leading to additional inflammation that releases mast cell mediators that cause further endothelial damage, in a worsening spiral. 3/
