Discover and read the best of Twitter Threads about #lambda

Carlos MORENO

@CarlosMorenoFr

Quand on entend le porte-parole du Gouvernement qualifier le début de la 5ème vague de "fulgurant", je me dis que :
(a) pas grande chose d'apprise après deux ans de pandémie
(b) faire un peu de maths de base, ne leur fera pas de mal
#Thread

https://twitter.com/LeHuffPost/status/1462376512360005632

Nous sommes un certain nombre à dire depuis l'été dernier "que nous vivons encore et toujours dans une période de pandémie et qu'il serait une erreur de considérer qu’elle est sur le déclin, que le pire est derrière nous". La lecture est surtout en terme des tendances globales🔽

On disait aussi "ns restons sur une compréhension approximative du #SARSCOV2 au niveau biologique & socio comportementale, qui malgré le travail exceptionnel des scientifiques du monde entier, présente tjs des aspects imprédictibles, qu’il faut accepter avec humilité, patience"🔽

Read 16 tweets

Mellanie Fontes-Dutra 💉😷

@mellziland

Boas notícias:
🔹Vacinas SEGUEM PROTEGENDO contra as versões da variante #Delta (AY.4.2, "Delta Plus" e outras), as variantes #Lambda, #Mu e A.30
🔹Publicado na @NEJM os dados da @pfizer em crianças de 5-11 anos

Venha conferir esse e mais dados no fio! 🧶👇

https://twitter.com/mellziland/status/1450886512598519820

Um estudo da Dinamarca🇩🇰 demonstrou que, após 2 meses da dose 2 e em comparação com a linhagem B.1 (D614G), a AY.4.2 teve uma redução de 2,3x nos títulos medianos de neutralização, não sendo mais resistente à neutralização em relação a outras versões circulantes da #Delta

Já a variante B.1.617.2 + E484K mostrou uma redução de 4,2x na neutralização, porém é uma variante com menor predominância do que outras versões da #Delta. Essa redução não é superior ao que vemos com a #Beta a qual sabemos que as vacinas geram proteção medrxiv.org/content/10.110…

Read 17 tweets

Mellanie Fontes-Dutra 💉😷

@mellziland

Muita gente ficou surpresa com as notícias referentes a C.1.2, uma variante possível aumento na transmissão e com algum escape imunológico anunciada pelo Inst. Nacional de Doenças Transmissíveis da 🇿🇦 e da Plataforma de Inov.e Seq. de Pesq. KwaZulu-Natal

Acompanha 🧶👇

RESUMO:
🔹Variante com características preocupantes, mas que não tem circulação global
🔹Nada nos diz que vacinas não abrangeriam ela
🔹Mais um indicativo de que o vírus está se adaptando
🔹A desigualdade de distr. de 💉 no 🌎 É UM PROBLEMÃO
🔹💉E 😷pelo amor de Deus

Detalhes👇

Não é segredo, nem novidade, que a permanência desse estado de transmissão elevado, que é construído por vários fatores, (baixa cobertura 💉, falta de adesão adequada a medidas como uso de 😷, p.ex), gera um risco de vermos novas variantes surgirem

https://twitter.com/mellziland/status/1349752609368891394

Read 29 tweets

Carlos MORENO

@CarlosMorenoFr

#COVID19 Une grande difficulté face est de comprendre que cette viralité touche nos modes de vie bien au delà d'une courte période, la plus visible celle des pics. C'est une nouvelle réalité qui doit aller avec une autre pédagogie dans un monde globalisé, interconnecté #Thread

Si nous voulons retrouver de l'apaisement face aux montées des extrémismes, manipulations, un effort d'explication est indispensable pour sortir de NOS certitudes. Le #COVID19 a encore des zones d'ombre, c'est un défi pour la science qui avance à grands pas pour le comprendre /↩️

En date du 6 juillet l’#OMS a fait état des 4 VOC (Variant of Concern) et 4 VOI (Variant of Interest) #COVID19 identifiés. #Delta qui sévit en Europe actuellement s’est déployée massivement en #Inde avant d'arriver en #UK, début décembre et ensuite se propager aussi en France/↩️

Read 29 tweets

TraderStef

@TraderStef

The Disregard of #InformedConsent and Echoes of Nuremberg Part 2 - “The Great Pivot” - Jab hesitancy is informed, literate, and sophisticated, but government agencies, officials, and politicos pushed false narratives - by @TraderStef 4 #CrushTheStreet #ADE crushthestreet.com/articles/break…

I am moving "The Great Pivot & Echoes of Nuremberg Part 2" #InformedConsent2 (the thread from @RWMaloneMD's gracious RT

https://twitter.com/TraderStef/status/1422185999107506177

) to my acct original here. Replies were breaking apart/not keeping continuity under his RT. Chronology is now intact. Apology for move.

Here is a link to PART 1 of “The Disregard of Informed Consent & Echoes of Nuremberg” (is hash tagged as #InformedConsent). That thread's continuity is intact and extensive, from March 31 to Aug 3.

https://twitter.com/TraderStef/status/1377449333944111105

Read 178 tweets

Mellanie Fontes-Dutra, PhD 💉😷

@mellziland

As atenções voltadas para a #Delta, e precisam estar. A #Delta já é a variante de predominância global, e aqui no 🇧🇷, temos a #Gama até o momento predominante. Será que a #Delta predominaria sobre a #Gama?

Não sabemos, mas pode ter mais "competidoras" nessa história 🧶👇

Ainda em Março/21, eu fiz um fio de um brilhante trabalho de vigilância da @fiocruz mostrando que a #Gama (que nos referíamos como P.1 naquele momento) poderia estar sofrendo adaptações em virtude do seu amplo espalhamento no país

https://twitter.com/mellziland/status/1374779412269383680

Uma breve revisão de porque uma transmissão acelerada tem relação com um risco aumentado em vermos mais variantes surgirem, e dentre elas, alguma(s) que possa(m) nos preocupar

https://twitter.com/mellziland/status/1366570417268342787

Read 25 tweets

The Sato Lab (Kei Sato)

@SystemsVirology

BREAKING🔔 The 3rd preprint from G2P-Japan - we elucidated the evolution and virological phenotype of #Lambda variant (aka C.37 lineage). Lambda is resistant to vaccine-induced antiviral immunity. Please retweet 1/3
biorxiv.org/content/10.110…

Mutational anaysis showed that a large deletion in the N-terminal domain of the Lambda spike protein (246-253 residues) is responsible for the resiscence to neutralizing antibodies. 2/3

Moreover, #L452Q mutation in Lambda increases viral infectivity, like the case of #L452R mutation, a characteristic of #Delta. Our data suggest that 1) increasing viral infectivity and 2) evading antiviral immunity are crucial for the efficient spread in the human population 3/3

Read 3 tweets

Corné Van Hoepen

@Cvanhoepen

What is Lambda variant?

C.37 - known as Lambda variant is believed to have originated in Peru and deemed “variant of interest” by @WHO June 14.

“There is currently limited evidence available about this variant,” Dr. Alicia Demirjian of PHE told the @BBCNews.

#COVID19 #Lambda

The Lambda strain is puzzling @WHO after spreading to 30 countries in four weeks.

“Lambda has a unique pattern of seven mutations in the spike protein that the virus uses to infect human cells,” Jeff Barrett of British Covid-19 Genomics told Financial Times

#COVID19 #Lambda

While the strain is deemed highly transmissible, the @WHO stresses “further studies are required to validate continued effectiveness of vaccines,” against Lambda strain.

Canadian health officials say as of July 8, 11 cases of the Covid-19 mutation have been reported.

#Lambda

Read 3 tweets

🔴 Daniel 🏳️‍🌈🏳️‍⚧

@guener_Retter

Ich verlange von niemanden komplette soziale Isolation.
Ich persönlich hatte seit Beginn der Pandemie konstant soziale Kontakte.
Nur eben: nur eine Hand voll in Präsenz.
Alle möglichst Einzeln, auch nicht alle in einer Woche.

Damit, falls doch was passiert, alles übersichtlich bleibt.
Zudem Kontakttagebuch. Mein Maximum war 3 Personen über zwei Wochen. Wobei zwei davon ein Bett teilen.

Was auch immer geht: telefonieren. Online spielen. Aber das ist eh meine gängige Kommunikation mit Menschen, die weiter weg wohnen. War ich also schon vor der Pandemie gewohnt.

Read 10 tweets

Carol Perelman

@carol_perelman

Un pequeño hilo 🧵 para descansar un poco de la #Deltamanía 🦠😉y seguir explorando el alfabeto griego de Variantes:

👉🏻Hablemos de #LambdaVariant Λ, también llamada #andina por haber sido detectada inicialmente en Perú🇵🇪, y de la q aún sabemos poco
1/10
#VarianteAndina #Lambda

🦠Empezando por aclarar q entre más oportunidad le demos al virus de seguir replicándose, y al hacerlo encontrar mutaciones q le dan ventaja (infección, escape, virulencia), seguirá retando nuestras medidas de mitigación:

Así q urge ponerle al virus barreras ➡️: 💉+😷+ 🌬
2/

Esta variante Λ se detectó desde 2020 en Perú🇵🇪,…y ya está presente en al menos 31 países, entre los que está México

Importante mencionar q sabemos menos de las variantes detectadas en regiones donde la secuenciación genómica no es tan amplía…
3/

Read 10 tweets

LabMolCelVirol

@LabMolCelVirol

Preprint (no revisado por pares aún) de nuestro trabajo sobre eficacia de anticuerpos neutralizantes generados por #CoronaVac (75 muestras) frente a variantes #Lambda (C37), #Gamma (P1) y #Alpha (B117) de #SARSCoV2 #Sinovac
📣medrxiv.org/content/10.110…

Variante #Gamma (preocupación) posee 11 mutaciones incluyendo algunas en el sitio de unión al receptor (RBD) asociadas con un incremento en la unión al receptor ACE2 y la infectividad (N501Y) o a la reducción en la eficacia de anticuerpos neutralizantes (K417T and E484K)

Variante #Lambda (interés) tiene un patrón único de 7 mutaciones (Δ246-252, G75V, T76I, L452Q, F490S, D614G, T859N)

Read 9 tweets

affeu

@affeu2

Thread: Wie viele rechte Augenklappen benötigt die hessische Polizeiführung nach mehr als 100 Verfahren gegen PolizistInnen, die kein rechtes Netzwerk erkennen möchte? Ein intimer Blick ins #SEK. 1/x #Frankfurt #Polizeiskandal #Hanau #Lambda #IB #Bereswill

https://twitter.com/affeu2/status/1402555930240299008?s=20

Nur mal für den aktuellen Blick, auf den jüngsten #Polizeiskandal & dessen bis jetzt bekannten Ausmaß: 49 Polizeibeamte, 2 ehemalige Polizisten, 5 externe Personen, in insgesamt 7 #Chatgruppen, die #rechtsextreme Inhalte austauschten. #Frankfurt #SEK 2/x

Der seit 2014 eingesetzte Polizeipräsident Gerhard #Bereswill ist als verantwortlicher Polizeipräsident von #Frankfurt nicht haltbar. Unter seiner Führung sind mehr als 100 Verfahren gegen seine #Polizei-BeamtInnen wegen #Rechtsextremismus uvw. eingeleitet worden. #SEK 3/x

Read 14 tweets

Medical Science and Technology #earlytreatments

@MedicalScitech

A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses.

Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011

The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic.

Read 199 tweets

Medical Science and Technology #earlytreatments

@MedicalScitech

🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…

Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus.

Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component.

Read 213 tweets

Bert Weingarten

@WeingartenDE

Logik zum #Öffnungsplan der #Bundesregierung
Wo, wie und wie schnell infiziert man sich mit dem #Coronavirus? Solange die Regierung Entscheidungen - magels Datenlage - ohne Evidenz trifft, solange ist es Willkür, wann welche Bereiche geöffnet und andere geschlossen bleiben #Spahn

https://twitter.com/welt/status/1367406461962358784

Die Mutante #B117 erreicht in diesen Tagen -in den ersten Bundesländern- ihre #Dominanz. #R steigt zeitgleich und die #Regierung erhöht per #Öffnungsplan die #Mobilität: B117, Öffnungsplan u. gesteigerte Mobilität sind drei Faktoren die logisch #R exponentiell beeinflussen können

Zeitgleich werden #Kitas u. #Schulen geöffnet, also die Versammlungsorte, vor deren Öffnung uns Experten und Ärzte aus #Israel u. Kanada warnen. Begründet wird die #Öffnung mit "Meinungen" von Wissenschaftlern, deren #Studien -manipulierte Daten- aus #Schweden zitieren #twlz #KMK

Read 243 tweets

Medical Science and Technology #earlytreatments

@MedicalScitech

Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.

🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.

High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others

Read 236 tweets

Medical Science and Technology #earlytreatments

@MedicalScitech

⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.

⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.

⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.

Read 235 tweets

Mark Birch, Community Builder

@marksbirch

Excited for my first re:Invent and getting ready for the @ajassy keynote coming up!

reinvent.awsevents.com

#awsreinvent #AWS #cloud

Loving the opening music act 🎸

Zach Person is the musician playing, so awesome...

Here is his Instagram - instagram.com/zachperson/

Read 75 tweets

Matt Fuller

@matthewdfuller

I know "serverless" is sometimes called out as a buzzword, but the model #AWS #Lambda introduced quite literally changed my career (and consequently, my life). (Thread)

https://twitter.com/ajaynairthinks/status/1327372121568264192

A few years ago, I started an open source security auditing tool called CloudSploit. It got a lot of users, but many were asking me if I could offer a hosted version as an API (and they were willing to pay for it!).

I had some experience with server side dev, but CloudSploit had unique challenges. It would have to horizontally scale out / back very quickly as it was running these security scans. I built a quick set of services using EC2, but it quickly became expensive and hard to manage.

Read 8 tweets

@CookiesNotFound

What are some database engines that works great with serverless architecture?

#database #CodeNewbie #Serverless #javascript

Note to Self: MongoDB can be used with serverless functions by caching the initial connection.
database engines were designed much before the serverless architecture was a thing.

a connection to the database is always persistent. meaning, it lasts for a really long time.

also, there is a limit(imposed by DBaaS provider) on how many connections a database can have at any given timestamp.

a lambda function is invoked every time a client(generally, browsers) creates a connection. this means a new connection to the database as well.

Read 6 tweets

Ricardo Borillo

@borillo

Hoy me gustaría compartir algunas reflexiones fruto de las últimas novedades aparecidas y mis experiencias en cliente con #infrastructureascode en #AWS. Vamos al lío 👇

Siempre me he sentido más atraido hacia el enfoque declarativo por su falsa sensación de control y orden, pero con configuraciones grandes, poder refactorizar el código hacia abstracciones propias y modificar su definición/parametrización con código ha sido determinante

En ese sentido, #cloudformation como tal siempre me ha parecido muy locura y un formato más de bajo nivel que otra cosa. En general siempre trabajo con herramientas que lo generan como #serverlessframework o #amplify

Read 18 tweets

Discover and read the best of Twitter Threads about #lambda

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Discover and read the best of Twitter Threads about #lambda

Most recents (24)

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