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How COVID actively suppresses and evades your immune system [Part 2]
Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/
Part 2 looks at how mild and moderate #COVID infection reprograms white #blood cells (#monocytes) to reduce #innate #immune functions and how it evades the mucus layer in our #nose. 🧵1/
An unrolled one-page web view for both parts of this long thread that may be easier to read or share can be found here ( ). 2/
If you haven't read part 1 yet on how the virus hides from T-cells and NK immune cells you can find it here: 3/
How #COVID actively suppresses and evades your immune system [Part 1]
This thread highlights multiple methods that the virus uses to help keep reinfecting people including MHC-I and interferon suppression, evasion of Natural Killer (NK) cells, and reprogramming of monocytes.🧵1/
This thread highlights multiple methods that the virus uses to help keep reinfecting people including MHC-I and interferon suppression, evasion of Natural Killer (NK) cells, and reprogramming of monocytes.🧵1/
An unrolled one-page web view for this long thread that may be easier to read or share can be found here ( ). 2/
COVID has been doing this to varying degrees since the beginning which further reinforces that a vaccine only policy is not enough to stop the cycle of sickness, long term disability, and death. 3/
Yes, children mostly produced Abs aimed at #Spike protein, which the virus uses to enter cells. Adults generate similar Abs, but also develop Abs against the #Nucleocapsid protein, which is essential for viral replication 2/
pubmed.ncbi.nlm.nih.gov/33154590/
pubmed.ncbi.nlm.nih.gov/33154590/
#Nucleocapsid protein is typically released in significant quantities only when a virus is widespread in the body.
What does it mean? The kids lacked nucleocapsid-specific Abs, which suggests that they aren’t experiencing widespread infection. 3/
What does it mean? The kids lacked nucleocapsid-specific Abs, which suggests that they aren’t experiencing widespread infection. 3/
Rethinking the genetic architecture of schizophrenia. - I wrote this with David Porteous in 2011. Apart from an over-emphasis on single rare mutations of large effect (less common for SCZ than for ASD), I think it holds up pretty well ncbi.nlm.nih.gov/pubmed/20380786
Updated in: The genetic architecture of neurodevelopmental disorders biorxiv.org/content/10.110…, from this book: onlinelibrary.wiley.com/doi/book/10.10…
And further updated (in more accessible form) in chapter on The Exceptions, in #INNATE press.princeton.edu/titles/13255.h…
@philipcball Hmm... I wouldn't summarise it quite like that. But if you've got your copy of #Innate lying around, chapter 9 gives an overview of how I think we should think about sex differences in brain wiring and in behavior 😉
@philipcball The difficulty is there are many different intertwined issues that require some care to tease apart. It's common to see, for example, people objecting to the over-interpretation of a finding therefore rejecting the finding itself
@philipcball One very general problem, highlighted by @ginarippon1, @Lise_Eliot and others, is that neuroimaging studies of sex diffs have many methodological problems. But that is a general issue with neuroimaging - it's just a bit crap.
I had a gentle insinuation of "neurosexism" from a questioner after a talk I gave last week, due to chapter on sex differences in #INNATE. For the record, here's what I think about such differences:
I don't think recognising that sex differences in behaviour exist in humans, as in other mammals, for good evolutionary reasons, is sexist. I think it's important if we want to understand many central aspects of human nature.
I certainly DO think it's sexist to take such differences as evidence that one sex is superior to the other. And it's definitely sexist to apply group average differences to derive expectations of individuals, which is the very definition of prejudice.
