Discover and read the best of Twitter Threads about #iNTS
Most recents (3)
Here it is!
#Inktober2020 day 1 in my #PathogenPortraits series. After years of studying this in cow bums, it had to be #EcoliO157
It causes bloody diarrhoea & if that wasn't bad enough, sometimes kidney failure & death. More info @
nhsinform.scot/illnesses-and-…
#sciart #microbiology
#Inktober2020 day 1 in my #PathogenPortraits series. After years of studying this in cow bums, it had to be #EcoliO157
It causes bloody diarrhoea & if that wasn't bad enough, sometimes kidney failure & death. More info @
nhsinform.scot/illnesses-and-…
#sciart #microbiology
#Inktober2020 day 2 in my #PathogenPortraits series. 'The Clap' (Neisseria gonorrhoeae) b/c who doesn't 💚 green purulent discharge?
It's sexually transmitted but also from mother->newborn during birth to cause blindness.
More info: microbewiki.kenyon.edu/index.php/Neis…
#sciart #microbiology
It's sexually transmitted but also from mother->newborn during birth to cause blindness.
More info: microbewiki.kenyon.edu/index.php/Neis…
#sciart #microbiology
#Inktober2020 day 3 in my #PathogenPortraits series. The very 💛golden💛 #MRSA.
Minds it's own business on your skin, but if it gets inside, methicillin won't do a thing to stop it.
More info at mrsaactionuk.net/MRSA.html #sciart #microbiology
Minds it's own business on your skin, but if it gets inside, methicillin won't do a thing to stop it.
More info at mrsaactionuk.net/MRSA.html #sciart #microbiology
1/
See our new @plospathogens paper with the Hinton Lab @jay_salsa on the role of the MacAB-TolC efflux pump during infection by invasive #Salmonella isolates from Africa. doi.org/10.1371/journa…
See our new @plospathogens paper with the Hinton Lab @jay_salsa on the role of the MacAB-TolC efflux pump during infection by invasive #Salmonella isolates from Africa. doi.org/10.1371/journa…
2/
Whole genome analysis of all sequenced African #iNTS isolates by @yan_salsa @NWenner and @implosian identified several variants of MacAB associated with each lineage.
Whole genome analysis of all sequenced African #iNTS isolates by @yan_salsa @NWenner and @implosian identified several variants of MacAB associated with each lineage.
3/
We showed these MacAB variants change resistance to the antimicrobial peptide C18G and alter #Salmonella replication in macrophages.
We showed these MacAB variants change resistance to the antimicrobial peptide C18G and alter #Salmonella replication in macrophages.
1/5
African S. Typhimurium ST313 has 23 Lineage 2-specific pseudogenes, discovered by @DrRobKingsley in 2009, inc ybjZ.
But what is function?
In collab with Jared Honeycutt @monack_lab, we've discovered that MacB (YbjZ) influences pathogenesis of ST313
journals.plos.org/plospathogens/…
African S. Typhimurium ST313 has 23 Lineage 2-specific pseudogenes, discovered by @DrRobKingsley in 2009, inc ybjZ.
But what is function?
In collab with Jared Honeycutt @monack_lab, we've discovered that MacB (YbjZ) influences pathogenesis of ST313
journals.plos.org/plospathogens/…
2/5
Genomes of 285 S. Typhimurium isolates revealed lineage-specific SNPs = macA & macB are pseudogenes
Suggesting that MacAB-TolC efflux pump is functional in S. Typhimurium ST19, but defective in ST313 Lineages 1 & 2
Genomes of 285 S. Typhimurium isolates revealed lineage-specific SNPs = macA & macB are pseudogenes
Suggesting that MacAB-TolC efflux pump is functional in S. Typhimurium ST19, but defective in ST313 Lineages 1 & 2
3/5
Beautiful expts designed by Jared Honeycutt & @monack_lab show MacA variant & truncated MacB protein made ST19 sensitive to C18G antimicrobial peptide
& the ST313 macAB SNPs reduced intra-macrophage replication & fitness in murine GI tract
See @monack_lab tweet for details
Beautiful expts designed by Jared Honeycutt & @monack_lab show MacA variant & truncated MacB protein made ST19 sensitive to C18G antimicrobial peptide
& the ST313 macAB SNPs reduced intra-macrophage replication & fitness in murine GI tract
See @monack_lab tweet for details
