Discover and read the best of Twitter Threads about #gastrulation
Most recents (3)
It is difficult to understand why @Nature publishes papers like this nature.com/articles/s4158… whose title promises much but which in the end is, simply, a data set with little insight & a number of misleading statements.
Perhaps the most valuable figures, which are not discussed in sufficient detail, are 2d and 4b where there we can see some spatial expression. Rather than genes that are the same, it would have been good to see differences.
Overall the technical work is good, probably useful, but the study is a superficial and misleading annotation of the data set to cell types: CDX1 and OTX2 as markers for Definitive Endoderm? HOX as a marker for the node?.
We’re excited to share our newest publication @nature. With #scRNAseq we investigated 10 key #epigenetic regulators in #embryogenesis. Interesting early task for #Polycomb! Meissner lab @MPI_MolGen & @HSCRB /w @helenekretzmer & Zachary D. Smith (1/13) nature.com/articles/s4158…
What is normal in #devbio? First, we generated a single-cell reference of WT mouse #gastrulation and early organogenesis to which we later compared mutant phenotypes. We identified 42 embryonic and extraembryonic cell states and placed them in a lineage tree. (2/13) 
Our WT reference is time-resolved covering #embryo stages E6.5-8.5. Variation is information: We pooled multiple embryos with unique SNP profiles per single-cell experiment; cell-to-embryo assignment is possible from scRNA data. (3/13)
#BSDBGenSoc2020 These days we all have other things in our minds, it is difficult to concentrate and many of my thoughts R w/ family anf friends in #Spain) but discussing our work, is an important part of our being and it is going to be important in the weeks and months to come.
While many, all, of us rather do al this in person, we are going to have to adjust in the weeks to come. #BSDBGenSoc2020 is a good way to explore how we are going to do it so, THANKS @_BSDB_ and @the_Node for organizing and running this.
My Tweetorial follows the phenomenal one from @TimFulton_1 @SteventonLab (with whom @AMA_Lab work closely) this morning and is very related.
And now onto the tweetorial in the form of a loooong thread.
And now onto the tweetorial in the form of a loooong thread.
